Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors

Descripción del Articulo

In order to investigate the underlying genetic structure and genomic ancestry proportions of Peruvian subpopulations, we analyzed 551 human samples of 25 localities from the Andean, Amazonian, and Coastal regions of Peru with a set of 40 ancestry informative insertion–deletion polymorphisms. Using g...

Descripción completa

Detalles Bibliográficos
Autores: Sandoval, Jose R., Salazar-Granara, Alberto, Acosta, Oscar, Castillo-Herrera, Wilder, Fujita, Ricardo, Pena, Sergio D. J., Santos, Fabricio R.
Formato: artículo
Fecha de Publicación:2013
Institución:Universidad de San Martín de Porres
Repositorio:USMP-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.usmp.edu.pe:20.500.12727/6146
Enlace del recurso:https://hdl.handle.net/20.500.12727/6146
https://doi.org/10.1038/jhg.2013.73
Nivel de acceso:acceso abierto
Materia:Grupo de ascendencia continental nativa americana
Análisis por conglomerados
Grupo de ascendencia continental europea
Genética de población
Mutación INDEL
https://purl.org/pe-repo/ocde/ford#3.02.00
Descripción
Sumario:In order to investigate the underlying genetic structure and genomic ancestry proportions of Peruvian subpopulations, we analyzed 551 human samples of 25 localities from the Andean, Amazonian, and Coastal regions of Peru with a set of 40 ancestry informative insertion–deletion polymorphisms. Using genotypes of reference populations from different continents for comparison, our analysis indicated that populations from all 25 Peruvian locations had predominantly Amerindian genetic ancestry. Among populations from the Titicaca Lake islands of Taquile, Amantani, Anapia, and Uros, and the Yanque locality from the southern Peruvian Andes, there was no significant proportion of non-autochthonous genomes, indicating that their genetic background is effectively derived from the first settlers of South America. However, the Andean populations from San Marcos, Cajamarca, Characato and Chogo, and coastal populations from Lambayeque and Lima displayed a low but significant European ancestry proportion. Furthermore, Amazonian localities of Pucallpa, Lamas, Chachapoyas, and Andean localities of Ayacucho and Huancayo displayed intermediate levels of non-autochthonous ancestry, mostly from Europe. These results are in close agreement with the documented history of post-Columbian immigrations in Peru and with several reports suggesting a larger effective size of indigenous inhabitants during the formation of the current country’s population.
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).