Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort
Descripción del Articulo
Objective: To determine the impact of homocysteine levels on damage accrual in systemic lupus erythematosus (SLE) patients. Methods: This longitudinal study was conducted in consecutive patients seen every 6 months at our Rheumatology Department since 2012. Patients with available homocysteine level...
Autores: | , , , , , , , , , , , , , , , |
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Formato: | artículo |
Fecha de Publicación: | 2018 |
Institución: | Universidad San Ignacio de Loyola |
Repositorio: | USIL-Institucional |
Lenguaje: | inglés |
OAI Identifier: | oai:repositorio.usil.edu.pe:usil/8437 |
Enlace del recurso: | https://repositorio.usil.edu.pe/handle/usil/8437 https://link.springer.com/article/10.1007/s10067-018-4389-3 https://doi.org/10.1007/s10067-018-4389-3 |
Nivel de acceso: | acceso embargado |
Materia: | Damage accrual Homocysteine Systemic lupus erythematosus |
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oai:repositorio.usil.edu.pe:usil/8437 |
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3128 |
spelling |
Zeña-Huancas, Paola A.Iparraguirre-López, HaydeeGamboa-Cárdenas, Rocío V.Reategui Sokolova, CristinaZevallos-Miranda, FranciscoMedina-Chinchón, MarielaPimentel-Quiroz, Victor RománElera-Fitzcarrald, ClaudiaSarmiento-Velasquez, OmarCucho-Venegas, Jorge M.Alfaro-Lozano, José L.Rodríguez-Bellido, Zoila J.Pastor-Asurza, César A.Perich-Campos, Risto A.Alarcón, Graciela S.Ugarte-Gil, Manuel F.2019-01-08T22:50:34Z2019-01-08T22:50:34Z2018-12Objective: To determine the impact of homocysteine levels on damage accrual in systemic lupus erythematosus (SLE) patients. Methods: This longitudinal study was conducted in consecutive patients seen every 6 months at our Rheumatology Department since 2012. Patients with available homocysteine levels and who had at least one subsequent visit were included. Univariable and multivariable Cox regression models were done to determine if homocysteine levels were predictive of damage accrual as per the SLICC Damage Index (SDI). The multivariable model was adjusted for pertinent variables (age at diagnosis, gender, socioeconomic status, disease duration, disease activity (SLEDAI), Framingham score, antimalarial and immunosuppressive drug use, average daily dose, and exposure time to prednisone (PDN)). Results: One hundred forty-five patients were included; their mean (SD) age at diagnosis was 43.70 (12.09) years, 136 (93.8%) were female, and nearly all were Mestizo. At baseline, disease duration was 7.55 (6.73) years; patients were followed for 3.54 (1.27) years. The SLEDAI was 5.60 (4.34), and the SDI 0.97 (1.35). The average daily PDN dose was 7.30 (5.78) mg/day and the time of PDN exposure was 7.36 (6.73) years. Mean homocysteine levels were 10.07 (3.71) μmol/L. The highest tertile of homocysteine levels predicted new damage accrual in the univariable and multivariable models [HR 1.78 (95% CI, 1.042–3.039); p = 0.035 and HR 2.045 (95% CI, 1.077–3.883); p = 0.029, respectively]. Increased levels (> 15 μmol/L) were found in 12 (8.3%) patients; 75 (51.7%) patients increased ≥ 1 SDI point. Conclusion: In SLE patients, homocysteine levels predicted damage accrual independently of other well-known risk factors for such occurrence. © 2018, International League of Associations for Rheumatology (ILAR).Revisado por paresapplication/pdfZeña-Huancas, P. A., Iparraguirre-López, H., Gamboa-Cárdenas, R. V., Reátegui-Sokolova, C., Zevallos-Miranda, F., Medina-Chinchon, M., ... & Alfaro-Lozano, J. L. (2019). Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort. Clinical rheumatology, 38(4), 1139-1146.10.1007/s10067-018-4389-3Clinical Rheumatologyhttps://repositorio.usil.edu.pe/handle/usil/8437https://link.springer.com/article/10.1007/s10067-018-4389-3https://doi.org/10.1007/s10067-018-4389-3engSpringer Londoninfo:eu-repo/semantics/embargoedAccessUniversidad San Ignacio de LoyolaRepositorio Institucional - USILreponame:USIL-Institucionalinstname:Universidad San Ignacio de Loyolainstacron:USILDamage accrualHomocysteineSystemic lupus erythematosusHomocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohortinfo:eu-repo/semantics/articleusil/8437oai:repositorio.usil.edu.pe:usil/84372022-01-31 17:00:35.797https://repositorio.usil.edu.peRepositorio institucional de la Universidad San Ignacio de Loyolabdigital@metabiblioteca.com |
dc.title.en.fl_str_mv |
Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort |
title |
Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort |
spellingShingle |
Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort Zeña-Huancas, Paola A. Damage accrual Homocysteine Systemic lupus erythematosus |
title_short |
Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort |
title_full |
Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort |
title_fullStr |
Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort |
title_full_unstemmed |
Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort |
title_sort |
Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort |
author |
Zeña-Huancas, Paola A. |
author_facet |
Zeña-Huancas, Paola A. Iparraguirre-López, Haydee Gamboa-Cárdenas, Rocío V. Reategui Sokolova, Cristina Zevallos-Miranda, Francisco Medina-Chinchón, Mariela Pimentel-Quiroz, Victor Román Elera-Fitzcarrald, Claudia Sarmiento-Velasquez, Omar Cucho-Venegas, Jorge M. Alfaro-Lozano, José L. Rodríguez-Bellido, Zoila J. Pastor-Asurza, César A. Perich-Campos, Risto A. Alarcón, Graciela S. Ugarte-Gil, Manuel F. |
author_role |
author |
author2 |
Iparraguirre-López, Haydee Gamboa-Cárdenas, Rocío V. Reategui Sokolova, Cristina Zevallos-Miranda, Francisco Medina-Chinchón, Mariela Pimentel-Quiroz, Victor Román Elera-Fitzcarrald, Claudia Sarmiento-Velasquez, Omar Cucho-Venegas, Jorge M. Alfaro-Lozano, José L. Rodríguez-Bellido, Zoila J. Pastor-Asurza, César A. Perich-Campos, Risto A. Alarcón, Graciela S. Ugarte-Gil, Manuel F. |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Zeña-Huancas, Paola A. Iparraguirre-López, Haydee Gamboa-Cárdenas, Rocío V. Reategui Sokolova, Cristina Zevallos-Miranda, Francisco Medina-Chinchón, Mariela Pimentel-Quiroz, Victor Román Elera-Fitzcarrald, Claudia Sarmiento-Velasquez, Omar Cucho-Venegas, Jorge M. Alfaro-Lozano, José L. Rodríguez-Bellido, Zoila J. Pastor-Asurza, César A. Perich-Campos, Risto A. Alarcón, Graciela S. Ugarte-Gil, Manuel F. |
dc.subject.en.fl_str_mv |
Damage accrual Homocysteine Systemic lupus erythematosus |
topic |
Damage accrual Homocysteine Systemic lupus erythematosus |
description |
Objective: To determine the impact of homocysteine levels on damage accrual in systemic lupus erythematosus (SLE) patients. Methods: This longitudinal study was conducted in consecutive patients seen every 6 months at our Rheumatology Department since 2012. Patients with available homocysteine levels and who had at least one subsequent visit were included. Univariable and multivariable Cox regression models were done to determine if homocysteine levels were predictive of damage accrual as per the SLICC Damage Index (SDI). The multivariable model was adjusted for pertinent variables (age at diagnosis, gender, socioeconomic status, disease duration, disease activity (SLEDAI), Framingham score, antimalarial and immunosuppressive drug use, average daily dose, and exposure time to prednisone (PDN)). Results: One hundred forty-five patients were included; their mean (SD) age at diagnosis was 43.70 (12.09) years, 136 (93.8%) were female, and nearly all were Mestizo. At baseline, disease duration was 7.55 (6.73) years; patients were followed for 3.54 (1.27) years. The SLEDAI was 5.60 (4.34), and the SDI 0.97 (1.35). The average daily PDN dose was 7.30 (5.78) mg/day and the time of PDN exposure was 7.36 (6.73) years. Mean homocysteine levels were 10.07 (3.71) μmol/L. The highest tertile of homocysteine levels predicted new damage accrual in the univariable and multivariable models [HR 1.78 (95% CI, 1.042–3.039); p = 0.035 and HR 2.045 (95% CI, 1.077–3.883); p = 0.029, respectively]. Increased levels (> 15 μmol/L) were found in 12 (8.3%) patients; 75 (51.7%) patients increased ≥ 1 SDI point. Conclusion: In SLE patients, homocysteine levels predicted damage accrual independently of other well-known risk factors for such occurrence. © 2018, International League of Associations for Rheumatology (ILAR). |
publishDate |
2018 |
dc.date.accessioned.none.fl_str_mv |
2019-01-08T22:50:34Z |
dc.date.available.none.fl_str_mv |
2019-01-08T22:50:34Z |
dc.date.issued.fl_str_mv |
2018-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
dc.identifier.citation.en.fl_str_mv |
Zeña-Huancas, P. A., Iparraguirre-López, H., Gamboa-Cárdenas, R. V., Reátegui-Sokolova, C., Zevallos-Miranda, F., Medina-Chinchon, M., ... & Alfaro-Lozano, J. L. (2019). Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort. Clinical rheumatology, 38(4), 1139-1146. |
dc.identifier.doi.none.fl_str_mv |
10.1007/s10067-018-4389-3 |
dc.identifier.journal.en.fl_str_mv |
Clinical Rheumatology |
dc.identifier.uri.none.fl_str_mv |
https://repositorio.usil.edu.pe/handle/usil/8437 https://link.springer.com/article/10.1007/s10067-018-4389-3 https://doi.org/10.1007/s10067-018-4389-3 |
identifier_str_mv |
Zeña-Huancas, P. A., Iparraguirre-López, H., Gamboa-Cárdenas, R. V., Reátegui-Sokolova, C., Zevallos-Miranda, F., Medina-Chinchon, M., ... & Alfaro-Lozano, J. L. (2019). Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort. Clinical rheumatology, 38(4), 1139-1146. 10.1007/s10067-018-4389-3 Clinical Rheumatology |
url |
https://repositorio.usil.edu.pe/handle/usil/8437 https://link.springer.com/article/10.1007/s10067-018-4389-3 https://doi.org/10.1007/s10067-018-4389-3 |
dc.language.iso.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.en.fl_str_mv |
Springer London |
dc.source.es_ES.fl_str_mv |
Universidad San Ignacio de Loyola Repositorio Institucional - USIL |
dc.source.none.fl_str_mv |
reponame:USIL-Institucional instname:Universidad San Ignacio de Loyola instacron:USIL |
instname_str |
Universidad San Ignacio de Loyola |
instacron_str |
USIL |
institution |
USIL |
reponame_str |
USIL-Institucional |
collection |
USIL-Institucional |
repository.name.fl_str_mv |
Repositorio institucional de la Universidad San Ignacio de Loyola |
repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
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1790534371966451712 |
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13.894945 |
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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).