Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort

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Objective: To determine the impact of homocysteine levels on damage accrual in systemic lupus erythematosus (SLE) patients. Methods: This longitudinal study was conducted in consecutive patients seen every 6 months at our Rheumatology Department since 2012. Patients with available homocysteine level...

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spelling Zeña-Huancas, Paola A.Iparraguirre-López, HaydeeGamboa-Cárdenas, Rocío V.Reategui Sokolova, CristinaZevallos-Miranda, FranciscoMedina-Chinchón, MarielaPimentel-Quiroz, Victor RománElera-Fitzcarrald, ClaudiaSarmiento-Velasquez, OmarCucho-Venegas, Jorge M.Alfaro-Lozano, José L.Rodríguez-Bellido, Zoila J.Pastor-Asurza, César A.Perich-Campos, Risto A.Alarcón, Graciela S.Ugarte-Gil, Manuel F.2019-01-08T22:50:34Z2019-01-08T22:50:34Z2018-12Objective: To determine the impact of homocysteine levels on damage accrual in systemic lupus erythematosus (SLE) patients. Methods: This longitudinal study was conducted in consecutive patients seen every 6 months at our Rheumatology Department since 2012. Patients with available homocysteine levels and who had at least one subsequent visit were included. Univariable and multivariable Cox regression models were done to determine if homocysteine levels were predictive of damage accrual as per the SLICC Damage Index (SDI). The multivariable model was adjusted for pertinent variables (age at diagnosis, gender, socioeconomic status, disease duration, disease activity (SLEDAI), Framingham score, antimalarial and immunosuppressive drug use, average daily dose, and exposure time to prednisone (PDN)). Results: One hundred forty-five patients were included; their mean (SD) age at diagnosis was 43.70 (12.09) years, 136 (93.8%) were female, and nearly all were Mestizo. At baseline, disease duration was 7.55 (6.73) years; patients were followed for 3.54 (1.27) years. The SLEDAI was 5.60 (4.34), and the SDI 0.97 (1.35). The average daily PDN dose was 7.30 (5.78) mg/day and the time of PDN exposure was 7.36 (6.73) years. Mean homocysteine levels were 10.07 (3.71) μmol/L. The highest tertile of homocysteine levels predicted new damage accrual in the univariable and multivariable models [HR 1.78 (95% CI, 1.042–3.039); p = 0.035 and HR 2.045 (95% CI, 1.077–3.883); p = 0.029, respectively]. Increased levels (> 15 μmol/L) were found in 12 (8.3%) patients; 75 (51.7%) patients increased ≥ 1 SDI point. Conclusion: In SLE patients, homocysteine levels predicted damage accrual independently of other well-known risk factors for such occurrence. © 2018, International League of Associations for Rheumatology (ILAR).Revisado por paresapplication/pdfZeña-Huancas, P. A., Iparraguirre-López, H., Gamboa-Cárdenas, R. V., Reátegui-Sokolova, C., Zevallos-Miranda, F., Medina-Chinchon, M., ... & Alfaro-Lozano, J. L. (2019). Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort. Clinical rheumatology, 38(4), 1139-1146.10.1007/s10067-018-4389-3Clinical Rheumatologyhttps://repositorio.usil.edu.pe/handle/usil/8437https://link.springer.com/article/10.1007/s10067-018-4389-3https://doi.org/10.1007/s10067-018-4389-3engSpringer Londoninfo:eu-repo/semantics/embargoedAccessUniversidad San Ignacio de LoyolaRepositorio Institucional - USILreponame:USIL-Institucionalinstname:Universidad San Ignacio de Loyolainstacron:USILDamage accrualHomocysteineSystemic lupus erythematosusHomocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohortinfo:eu-repo/semantics/articleusil/8437oai:repositorio.usil.edu.pe:usil/84372022-01-31 17:00:35.797https://repositorio.usil.edu.peRepositorio institucional de la Universidad San Ignacio de Loyolabdigital@metabiblioteca.com
dc.title.en.fl_str_mv Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort
title Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort
spellingShingle Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort
Zeña-Huancas, Paola A.
Damage accrual
Homocysteine
Systemic lupus erythematosus
title_short Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort
title_full Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort
title_fullStr Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort
title_full_unstemmed Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort
title_sort Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort
author Zeña-Huancas, Paola A.
author_facet Zeña-Huancas, Paola A.
Iparraguirre-López, Haydee
Gamboa-Cárdenas, Rocío V.
Reategui Sokolova, Cristina
Zevallos-Miranda, Francisco
Medina-Chinchón, Mariela
Pimentel-Quiroz, Victor Román
Elera-Fitzcarrald, Claudia
Sarmiento-Velasquez, Omar
Cucho-Venegas, Jorge M.
Alfaro-Lozano, José L.
Rodríguez-Bellido, Zoila J.
Pastor-Asurza, César A.
Perich-Campos, Risto A.
Alarcón, Graciela S.
Ugarte-Gil, Manuel F.
author_role author
author2 Iparraguirre-López, Haydee
Gamboa-Cárdenas, Rocío V.
Reategui Sokolova, Cristina
Zevallos-Miranda, Francisco
Medina-Chinchón, Mariela
Pimentel-Quiroz, Victor Román
Elera-Fitzcarrald, Claudia
Sarmiento-Velasquez, Omar
Cucho-Venegas, Jorge M.
Alfaro-Lozano, José L.
Rodríguez-Bellido, Zoila J.
Pastor-Asurza, César A.
Perich-Campos, Risto A.
Alarcón, Graciela S.
Ugarte-Gil, Manuel F.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Zeña-Huancas, Paola A.
Iparraguirre-López, Haydee
Gamboa-Cárdenas, Rocío V.
Reategui Sokolova, Cristina
Zevallos-Miranda, Francisco
Medina-Chinchón, Mariela
Pimentel-Quiroz, Victor Román
Elera-Fitzcarrald, Claudia
Sarmiento-Velasquez, Omar
Cucho-Venegas, Jorge M.
Alfaro-Lozano, José L.
Rodríguez-Bellido, Zoila J.
Pastor-Asurza, César A.
Perich-Campos, Risto A.
Alarcón, Graciela S.
Ugarte-Gil, Manuel F.
dc.subject.en.fl_str_mv Damage accrual
Homocysteine
Systemic lupus erythematosus
topic Damage accrual
Homocysteine
Systemic lupus erythematosus
description Objective: To determine the impact of homocysteine levels on damage accrual in systemic lupus erythematosus (SLE) patients. Methods: This longitudinal study was conducted in consecutive patients seen every 6 months at our Rheumatology Department since 2012. Patients with available homocysteine levels and who had at least one subsequent visit were included. Univariable and multivariable Cox regression models were done to determine if homocysteine levels were predictive of damage accrual as per the SLICC Damage Index (SDI). The multivariable model was adjusted for pertinent variables (age at diagnosis, gender, socioeconomic status, disease duration, disease activity (SLEDAI), Framingham score, antimalarial and immunosuppressive drug use, average daily dose, and exposure time to prednisone (PDN)). Results: One hundred forty-five patients were included; their mean (SD) age at diagnosis was 43.70 (12.09) years, 136 (93.8%) were female, and nearly all were Mestizo. At baseline, disease duration was 7.55 (6.73) years; patients were followed for 3.54 (1.27) years. The SLEDAI was 5.60 (4.34), and the SDI 0.97 (1.35). The average daily PDN dose was 7.30 (5.78) mg/day and the time of PDN exposure was 7.36 (6.73) years. Mean homocysteine levels were 10.07 (3.71) μmol/L. The highest tertile of homocysteine levels predicted new damage accrual in the univariable and multivariable models [HR 1.78 (95% CI, 1.042–3.039); p = 0.035 and HR 2.045 (95% CI, 1.077–3.883); p = 0.029, respectively]. Increased levels (> 15 μmol/L) were found in 12 (8.3%) patients; 75 (51.7%) patients increased ≥ 1 SDI point. Conclusion: In SLE patients, homocysteine levels predicted damage accrual independently of other well-known risk factors for such occurrence. © 2018, International League of Associations for Rheumatology (ILAR).
publishDate 2018
dc.date.accessioned.none.fl_str_mv 2019-01-08T22:50:34Z
dc.date.available.none.fl_str_mv 2019-01-08T22:50:34Z
dc.date.issued.fl_str_mv 2018-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.en.fl_str_mv Zeña-Huancas, P. A., Iparraguirre-López, H., Gamboa-Cárdenas, R. V., Reátegui-Sokolova, C., Zevallos-Miranda, F., Medina-Chinchon, M., ... & Alfaro-Lozano, J. L. (2019). Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort. Clinical rheumatology, 38(4), 1139-1146.
dc.identifier.doi.none.fl_str_mv 10.1007/s10067-018-4389-3
dc.identifier.journal.en.fl_str_mv Clinical Rheumatology
dc.identifier.uri.none.fl_str_mv https://repositorio.usil.edu.pe/handle/usil/8437
https://link.springer.com/article/10.1007/s10067-018-4389-3
https://doi.org/10.1007/s10067-018-4389-3
identifier_str_mv Zeña-Huancas, P. A., Iparraguirre-López, H., Gamboa-Cárdenas, R. V., Reátegui-Sokolova, C., Zevallos-Miranda, F., Medina-Chinchon, M., ... & Alfaro-Lozano, J. L. (2019). Homocysteine levels are independently associated with damage accrual in systemic lupus erythematosus patients from a Latin-American cohort. Clinical rheumatology, 38(4), 1139-1146.
10.1007/s10067-018-4389-3
Clinical Rheumatology
url https://repositorio.usil.edu.pe/handle/usil/8437
https://link.springer.com/article/10.1007/s10067-018-4389-3
https://doi.org/10.1007/s10067-018-4389-3
dc.language.iso.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.en.fl_str_mv Springer London
dc.source.es_ES.fl_str_mv Universidad San Ignacio de Loyola
Repositorio Institucional - USIL
dc.source.none.fl_str_mv reponame:USIL-Institucional
instname:Universidad San Ignacio de Loyola
instacron:USIL
instname_str Universidad San Ignacio de Loyola
instacron_str USIL
institution USIL
reponame_str USIL-Institucional
collection USIL-Institucional
repository.name.fl_str_mv Repositorio institucional de la Universidad San Ignacio de Loyola
repository.mail.fl_str_mv bdigital@metabiblioteca.com
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