Cuantificación de compuestos fenólicos y actividad antiinflamatoria de extractos de Phlebodium decumanum

• Autores: Tuesta Soto, Cony Kirlyn, Ramirez Trauco, Juana Emilce
• Formato: tesis de grado
• Fecha de Publicación: 2025
• Institución: Universidad Nacional De La Amazonía Peruana
• Repositorio: UNAPIquitos-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorio.unapiquitos.edu.pe:20.500.12737/11947
• Enlace del recurso: https://hdl.handle.net/20.500.12737/11947
• Nivel de acceso: acceso abierto
• Materia: Compuestos fenólicos; Antiinflamatorios; Extractos vegetales; Etánol; Coto chupo; Phlebodium decumanum; https://purl.org/pe-repo/ocde/ford#1.06.03

Medicinal plants represent an important source of bioactive compounds with therapeutic potential, including phenolics, which are well known for their antioxidant and anti-inflammatory properties. Phlebodium decumanum, an epiphytic fern native to the tropical regions of the Americas, has been traditionally used in folk medicine for its presumed health benefits; however, scientific evidence supporting its pharmacological properties remains limited. This study aimed to quantify the total phenolic content and evaluate the anti-inflammatory activity of extracts obtained from different organs of P. decumanum. Ethanolic extractions were performed, and the content of phenolic compounds, flavonoids, anthocyanins, and catechins was determined using UV-Vis spectrophotometric techniques. Anti-inflammatory activity was assessed through a heat-induced hemolysis inhibition assay in human erythrocytes, using concentrations of 10, 100, and 1000 µg/mL. The results indicate that the different parts of P. decumanum exhibit significant variations in the concentrations of phenolic compounds, flavonoids, anthocyanins, and catechins. The stem extract showed the highest percentage of inhibition at a concentration of 1000 µg/mL, whereas the rhizome extract demonstrated a significant increase in activity at 10 and 100 µg/mL. However, all groups exhibited IC₅₀ values greater than 1000 µg/mL. In conclusion, the various parts of P. decumanum present distinct phytochemical profiles and do not show anti-inflammatory activity at the concentrations evaluated.