Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone

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Escherichia coli ST131 has emerged as a globally disseminated multi-drug resistant clone associated with extra-intestinal infections acquired in the community or hospital. In Manhiça district, E. coli is among the top five leading bloodstream pathogens in children. We characterized E. coli strains c...

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Detalles Bibliográficos
Autores: Mandomando, I., Vubil, D., Boisen, N., Quintó, L., Ruiz, J., Sigaúque, B., Nhampossa, T., Garrine, M., Massora, S., Aide, P., Nhacolo, A., Pons, M.J., Bassat, Q., Vila, J., Macete, E., Scheutz, F., Levine, M.M.l,, Ruiz-Perez, F., Nataro, J.P., Alonso, P.L.
Formato: artículo
Fecha de Publicación:2020
Institución:Universidad Continental
Repositorio:CONTINENTAL-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.continental.edu.pe:20.500.12394/7550
Enlace del recurso:https://hdl.handle.net/20.500.12394/7550
https://doi.org/10.1371/journal.pntd.0008274
Nivel de acceso:acceso abierto
Materia:Enfermedades bacterianas
Niños
Escherichia coli
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oai_identifier_str oai:repositorio.continental.edu.pe:20.500.12394/7550
network_acronym_str UCON
network_name_str CONTINENTAL-Institucional
repository_id_str 4517
dc.title.es_ES.fl_str_mv Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
title Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
spellingShingle Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
Mandomando, I.
Enfermedades bacterianas
Niños
Escherichia coli
title_short Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
title_full Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
title_fullStr Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
title_full_unstemmed Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
title_sort Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
author Mandomando, I.
author_facet Mandomando, I.
Vubil, D.
Boisen, N.
Quintó, L.
Ruiz, J.
Sigaúque, B.
Nhampossa, T.
Garrine, M.
Massora, S.
Aide, P.
Nhacolo, A.
Pons, M.J.
Bassat, Q.
Vila, J.
Macete, E.
Scheutz, F.
Levine, M.M.l,
Ruiz-Perez, F.
Nataro, J.P.
Alonso, P.L.
author_role author
author2 Vubil, D.
Boisen, N.
Quintó, L.
Ruiz, J.
Sigaúque, B.
Nhampossa, T.
Garrine, M.
Massora, S.
Aide, P.
Nhacolo, A.
Pons, M.J.
Bassat, Q.
Vila, J.
Macete, E.
Scheutz, F.
Levine, M.M.l,
Ruiz-Perez, F.
Nataro, J.P.
Alonso, P.L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mandomando, I.
Vubil, D.
Boisen, N.
Quintó, L.
Ruiz, J.
Sigaúque, B.
Nhampossa, T.
Garrine, M.
Massora, S.
Aide, P.
Nhacolo, A.
Pons, M.J.
Bassat, Q.
Vila, J.
Macete, E.
Scheutz, F.
Levine, M.M.l,
Ruiz-Perez, F.
Nataro, J.P.
Alonso, P.L.
dc.subject.es_ES.fl_str_mv Enfermedades bacterianas
Niños
Escherichia coli
topic Enfermedades bacterianas
Niños
Escherichia coli
description Escherichia coli ST131 has emerged as a globally disseminated multi-drug resistant clone associated with extra-intestinal infections acquired in the community or hospital. In Manhiça district, E. coli is among the top five leading bloodstream pathogens in children. We characterized E. coli strains causing bacteremia in young children in a rural hospital of Mozambique, providing novel information on the occurrence of a new subclone of ST131 harboring both ExPEC and EAEC related genes and belonging to commonly reported O25:H4 and other serotypes. These data suggest the need for further understanding of pathogenesis and clinical impact of this new entity to inform prompt recognition and appropriate treatment.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-07-02T22:53:21Z
dc.date.available.none.fl_str_mv 2020-07-02T22:53:21Z
dc.date.created.none.fl_str_mv 2020
dc.date.issued.fl_str_mv 2020-05
dc.type.es_ES.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.es_ES.fl_str_mv Mandomando, I., Vubil, D., Boisen, N., Quintó, L., Ruiz, J., Sigaúque, B., Nhampossa, T., Garrine, M., Massora, S., Aide, P., Nhacolo, A., Pons, M.J., Bassat, Q., Vila, J., Macete, E. Scheutz, F., Levine, M.M.l., Ruiz-Perez, F., Nataro, J.P., Alonso, P.L. (2020). Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone. PLoS neglected tropical diseases, 14(5). https://doi.org/10.1371/journal.pntd.0008274
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12394/7550
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1371/journal.pntd.0008274
identifier_str_mv Mandomando, I., Vubil, D., Boisen, N., Quintó, L., Ruiz, J., Sigaúque, B., Nhampossa, T., Garrine, M., Massora, S., Aide, P., Nhacolo, A., Pons, M.J., Bassat, Q., Vila, J., Macete, E. Scheutz, F., Levine, M.M.l., Ruiz-Perez, F., Nataro, J.P., Alonso, P.L. (2020). Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone. PLoS neglected tropical diseases, 14(5). https://doi.org/10.1371/journal.pntd.0008274
url https://hdl.handle.net/20.500.12394/7550
https://doi.org/10.1371/journal.pntd.0008274
dc.language.iso.es_ES.fl_str_mv eng
language eng
dc.relation.es_ES.fl_str_mv https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008274
dc.rights.es_ES.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.accessRights.es_ES.fl_str_mv Acceso abierto
eu_rights_str_mv openAccess
rights_invalid_str_mv Acceso abierto
dc.format.es_ES.fl_str_mv application/pdf
dc.publisher.es_ES.fl_str_mv Universidad Continental
dc.source.es_ES.fl_str_mv Universidad Continental
Repositorio Institucional - Continental
dc.source.none.fl_str_mv reponame:CONTINENTAL-Institucional
instname:Universidad Continental
instacron:CONTINENTAL
instname_str Universidad Continental
instacron_str CONTINENTAL
institution CONTINENTAL
reponame_str CONTINENTAL-Institucional
collection CONTINENTAL-Institucional
bitstream.url.fl_str_mv https://repositorio.continental.edu.pe/bitstream/20.500.12394/7550/1/license.txt
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
bitstream.checksumAlgorithm.fl_str_mv MD5
repository.name.fl_str_mv Repositorio Continental
repository.mail.fl_str_mv dspaceconti@continental.edu.pe
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spelling Mandomando, I.Vubil, D.Boisen, N.Quintó, L.Ruiz, J.Sigaúque, B.Nhampossa, T.Garrine, M.Massora, S.Aide, P.Nhacolo, A.Pons, M.J.Bassat, Q.Vila, J.Macete, E.Scheutz, F.Levine, M.M.l,Ruiz-Perez, F.Nataro, J.P.Alonso, P.L.2020-07-02T22:53:21Z2020-07-02T22:53:21Z20202020-05Mandomando, I., Vubil, D., Boisen, N., Quintó, L., Ruiz, J., Sigaúque, B., Nhampossa, T., Garrine, M., Massora, S., Aide, P., Nhacolo, A., Pons, M.J., Bassat, Q., Vila, J., Macete, E. Scheutz, F., Levine, M.M.l., Ruiz-Perez, F., Nataro, J.P., Alonso, P.L. (2020). Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone. PLoS neglected tropical diseases, 14(5). https://doi.org/10.1371/journal.pntd.0008274https://hdl.handle.net/20.500.12394/7550https://doi.org/10.1371/journal.pntd.0008274Escherichia coli ST131 has emerged as a globally disseminated multi-drug resistant clone associated with extra-intestinal infections acquired in the community or hospital. In Manhiça district, E. coli is among the top five leading bloodstream pathogens in children. We characterized E. coli strains causing bacteremia in young children in a rural hospital of Mozambique, providing novel information on the occurrence of a new subclone of ST131 harboring both ExPEC and EAEC related genes and belonging to commonly reported O25:H4 and other serotypes. These data suggest the need for further understanding of pathogenesis and clinical impact of this new entity to inform prompt recognition and appropriate treatment.application/pdfengUniversidad Continentalhttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008274info:eu-repo/semantics/openAccessAcceso abiertoUniversidad ContinentalRepositorio Institucional - Continentalreponame:CONTINENTAL-Institucionalinstname:Universidad Continentalinstacron:CONTINENTALEnfermedades bacterianasNiñosEscherichia coliEscherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subcloneinfo:eu-repo/semantics/articleLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.continental.edu.pe/bitstream/20.500.12394/7550/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5120.500.12394/7550oai:repositorio.continental.edu.pe:20.500.12394/75502020-07-08 16:57:07.448Repositorio Continentaldspaceconti@continental.edu.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Escherichia coli ST131 clones harbouring AggR and AAF/V fimbriae causing bacteremia in Mozambican children: Emergence of new variant of fimH27 subclone
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