Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines

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Corrección del artículo (29 de marzo de 2015): https://doi.org/10.1155/2015/915270
Detalles Bibliográficos
Autores: Hernández Gorritti, Wilfredo Román, Paz Castillo Berríos, Juan, Carrasco Solís, Fernando Carlos, Vaisberg Wolach, Abraham, Spodine Spiridonova, Evgenia , Manzur Saffie, Jorge , Beyer, Lothar
Formato: artículo
Fecha de Publicación:2013
Institución:Universidad de Lima
Repositorio:ULIMA-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.ulima.edu.pe:20.500.12724/1489
Enlace del recurso:https://hdl.handle.net/20.500.12724/1489
https://doi.org/10.1155/2015/915270
Nivel de acceso:acceso abierto
Materia:Thiosemicarbazones
Palladium
Cell line, Tumor
In vitro techniques
Tiosemicarbazonas
Paladio
Línea celular tumoral
Técnicas in vitro
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dc.title.en_EN.fl_str_mv Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
title Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
spellingShingle Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
Hernández Gorritti, Wilfredo Román
Thiosemicarbazones
Palladium
Cell line, Tumor
In vitro techniques
Tiosemicarbazonas
Paladio
Línea celular tumoral
Técnicas in vitro
title_short Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
title_full Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
title_fullStr Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
title_full_unstemmed Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
title_sort Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
author Hernández Gorritti, Wilfredo Román
author_facet Hernández Gorritti, Wilfredo Román
Paz Castillo Berríos, Juan
Carrasco Solís, Fernando Carlos
Vaisberg Wolach, Abraham
Spodine Spiridonova, Evgenia 
Manzur Saffie, Jorge 
Beyer, Lothar
author_role author
author2 Paz Castillo Berríos, Juan
Carrasco Solís, Fernando Carlos
Vaisberg Wolach, Abraham
Spodine Spiridonova, Evgenia 
Manzur Saffie, Jorge 
Beyer, Lothar
author2_role author
author
author
author
author
author
dc.contributor.other.none.fl_str_mv Hernández Gorritti, Wilfredo Román
dc.contributor.author.fl_str_mv Hernández Gorritti, Wilfredo Román
Paz Castillo Berríos, Juan
Carrasco Solís, Fernando Carlos
Vaisberg Wolach, Abraham
Spodine Spiridonova, Evgenia 
Manzur Saffie, Jorge 
Beyer, Lothar
dc.subject.en_EN.fl_str_mv Thiosemicarbazones
Palladium
Cell line, Tumor
In vitro techniques
topic Thiosemicarbazones
Palladium
Cell line, Tumor
In vitro techniques
Tiosemicarbazonas
Paladio
Línea celular tumoral
Técnicas in vitro
dc.subject.es_PE.fl_str_mv Tiosemicarbazonas
Paladio
Línea celular tumoral
Técnicas in vitro
description Corrección del artículo (29 de marzo de 2015): https://doi.org/10.1155/2015/915270
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.other.none.fl_str_mv Artículo en Scopus y Web of Science
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dc.identifier.citation.es_PE.fl_str_mv Hernández Gorritti, W., Paz Castillo-Berríos, J., Carrasco, F., Vaisberg, A., Spodine, E., Manzur, J., ...y Beyer, L. (2013). Synthesis and characterization of new palladium (ii) thiosemicarbazone complexes and their cytotoxic activity against various human tumor cell lines. Bioinorganic Chemistry and Applications. https://doi.org/10.1155/2013/524701
dc.identifier.isbn.none.fl_str_mv urn:isbn:978-1-4503-6502-4
dc.identifier.issn.none.fl_str_mv 1687-479X
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12724/1489
dc.identifier.journal.none.fl_str_mv Bioinorganic Chemistry and Applications
dc.identifier.isni.none.fl_str_mv 0000000121541816
dc.identifier.wosid.none.fl_str_mv WOS:000354304100001
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1155/2015/915270
dc.identifier.scopusid.none.fl_str_mv 2-s2.0-84929347406
identifier_str_mv Hernández Gorritti, W., Paz Castillo-Berríos, J., Carrasco, F., Vaisberg, A., Spodine, E., Manzur, J., ...y Beyer, L. (2013). Synthesis and characterization of new palladium (ii) thiosemicarbazone complexes and their cytotoxic activity against various human tumor cell lines. Bioinorganic Chemistry and Applications. https://doi.org/10.1155/2013/524701
urn:isbn:978-1-4503-6502-4
1687-479X
Bioinorganic Chemistry and Applications
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url https://hdl.handle.net/20.500.12724/1489
https://doi.org/10.1155/2015/915270
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv urn:issn:1687-479X
dc.rights.*.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
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dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.publisher.country.none.fl_str_mv US
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv Repositorio Institucional - Ulima
Universidad de Lima
reponame:ULIMA-Institucional
instname:Universidad de Lima
instacron:ULIMA
instname_str Universidad de Lima
instacron_str ULIMA
institution ULIMA
reponame_str ULIMA-Institucional
collection ULIMA-Institucional
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spelling Hernández Gorritti, Wilfredo RománPaz Castillo Berríos, JuanCarrasco Solís, Fernando CarlosVaisberg Wolach, AbrahamSpodine Spiridonova, Evgenia Manzur Saffie, Jorge Beyer, LotharHernández Gorritti, Wilfredo Román2013Hernández Gorritti, W., Paz Castillo-Berríos, J., Carrasco, F., Vaisberg, A., Spodine, E., Manzur, J., ...y Beyer, L. (2013). Synthesis and characterization of new palladium (ii) thiosemicarbazone complexes and their cytotoxic activity against various human tumor cell lines. Bioinorganic Chemistry and Applications. https://doi.org/10.1155/2013/524701urn:isbn:978-1-4503-6502-41687-479Xhttps://hdl.handle.net/20.500.12724/1489Bioinorganic Chemistry and Applications0000000121541816WOS:000354304100001https://doi.org/10.1155/2015/9152702-s2.0-84929347406Corrección del artículo (29 de marzo de 2015): https://doi.org/10.1155/2015/915270The palladium(II) bis-chelate complexes of the type [Pd(TSC1-5)2] (6–10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC1 (1), 4-phenyl-1-(2'-chloro-benzaldehyde)-thiosemicarbazone, HTSC2 (2), 4-phenyl-1-(3'-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC3 (3), 4-phenyl-1-(2'-naphthaldehyde)-thiosemicarbazone, HTSC4 (4), and 4-phenyl-1-(1'-nitro-2'-naphthaldehyde)-thiosemicarbazone, HTSC5 (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and 1H- and 13C-NMR). The molecular structure of HTSC3, HTSC4, and [Pd(TSC1)2] (6) have been determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to PdII through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes (IC50 = 0.01–9.87¿µM) exhibited higher antiproliferative activity than their free ligands (IC50 = 23.48–70.86 and >250¿µM) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC3)2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02¿µM, resp.).application/htmlengHindawi Publishing CorporationUSurn:issn:1687-479Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/Repositorio Institucional - UlimaUniversidad de Limareponame:ULIMA-Institucionalinstname:Universidad de Limainstacron:ULIMAThiosemicarbazonesPalladiumCell line, TumorIn vitro techniquesTiosemicarbazonasPaladioLínea celular tumoralTécnicas in vitroSynthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Linesinfo:eu-repo/semantics/articleArtículo en Scopus y Web of ScienceOILICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ulima.edu.pe/bitstream/20.500.12724/1489/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD5220.500.12724/1489oai:repositorio.ulima.edu.pe:20.500.12724/14892025-04-25 09:31:01.52Repositorio Universidad de Limarepositorio@ulima.edu.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Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines
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