Drug-resistant epilepsy in children under 14 years: clinical and epidemiological characteristics at a tertiary hospital in Lima, Peru

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Objective: To determine the frequency and clinical characteristics of children with drug-resistant epilepsy treated at a national hospital in Lima, Peru. Materials and methods: A prospective, case-series study was conducted on patients under 14 years of age with drug-resistant epilepsy, treated betw...

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Detalles Bibliográficos
Autores: Espinoza-Quinteros, Ivan, Rivera-Burgos, Doris Liliana
Formato: artículo
Fecha de Publicación:2025
Institución:Universidad Peruana Cayetano Heredia
Repositorio:Revistas - Universidad Peruana Cayetano Heredia
Lenguaje:español
OAI Identifier:oai:revistas.upch.edu.pe:article/6314
Enlace del recurso:https://revistas.upch.edu.pe/index.php/RNP/article/view/6314
Nivel de acceso:acceso abierto
Materia:drug resistant epilepsy
antiepileptic drug
ketogenic diet
epilepsy/surgery
pediatrics
epilepsia resistente a los medicamentos
fármacos antiepilépticos
dieta cetogénica
epilepsia/cirugía
pediatría
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network_acronym_str REVUPCH
network_name_str Revistas - Universidad Peruana Cayetano Heredia
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dc.title.none.fl_str_mv Drug-resistant epilepsy in children under 14 years: clinical and epidemiological characteristics at a tertiary hospital in Lima, Peru
Epilepsia farmacorresistente en menores de 14 años: características clínicas y epidemiológicas en un hospital terciario de Lima, Perú
title Drug-resistant epilepsy in children under 14 years: clinical and epidemiological characteristics at a tertiary hospital in Lima, Peru
spellingShingle Drug-resistant epilepsy in children under 14 years: clinical and epidemiological characteristics at a tertiary hospital in Lima, Peru
Espinoza-Quinteros, Ivan
drug resistant epilepsy
antiepileptic drug
ketogenic diet
epilepsy/surgery
pediatrics
epilepsia resistente a los medicamentos
fármacos antiepilépticos
dieta cetogénica
epilepsia/cirugía
pediatría
title_short Drug-resistant epilepsy in children under 14 years: clinical and epidemiological characteristics at a tertiary hospital in Lima, Peru
title_full Drug-resistant epilepsy in children under 14 years: clinical and epidemiological characteristics at a tertiary hospital in Lima, Peru
title_fullStr Drug-resistant epilepsy in children under 14 years: clinical and epidemiological characteristics at a tertiary hospital in Lima, Peru
title_full_unstemmed Drug-resistant epilepsy in children under 14 years: clinical and epidemiological characteristics at a tertiary hospital in Lima, Peru
title_sort Drug-resistant epilepsy in children under 14 years: clinical and epidemiological characteristics at a tertiary hospital in Lima, Peru
dc.creator.none.fl_str_mv Espinoza-Quinteros, Ivan
Rivera-Burgos, Doris Liliana
author Espinoza-Quinteros, Ivan
author_facet Espinoza-Quinteros, Ivan
Rivera-Burgos, Doris Liliana
author_role author
author2 Rivera-Burgos, Doris Liliana
author2_role author
dc.subject.none.fl_str_mv drug resistant epilepsy
antiepileptic drug
ketogenic diet
epilepsy/surgery
pediatrics
epilepsia resistente a los medicamentos
fármacos antiepilépticos
dieta cetogénica
epilepsia/cirugía
pediatría
topic drug resistant epilepsy
antiepileptic drug
ketogenic diet
epilepsy/surgery
pediatrics
epilepsia resistente a los medicamentos
fármacos antiepilépticos
dieta cetogénica
epilepsia/cirugía
pediatría
description Objective: To determine the frequency and clinical characteristics of children with drug-resistant epilepsy treated at a national hospital in Lima, Peru. Materials and methods: A prospective, case-series study was conducted on patients under 14 years of age with drug-resistant epilepsy, treated between October 2013 and March 2014. Drug resistance was defined as the persistence of seizures despite the use of at least two antiepileptic drug regimens at maximum tolerated doses. Data were collected through interviews with family members and a review of medical records. Results: Forty-six patients were enrolled, representing 26.0 % of children under 14 years of age treated for epilepsy. The mean age was 8.46 ± 3.55 years, with 42.6 % of patients being female. The median age at seizure onset was 10.3 months, and the average duration of epilepsy was 6.5 years. Most patients (66 %) had symptomatic or cryptogenic epilepsy, with brain malformations and postnatal infections being the most common causes (14.9 % each). A total of 17 % of the patients were diagnosed with idiopathic epilepsy. The most common types of epilepsy were focal epilepsy not otherwise specified (42.6 %) and generalized epilepsy not otherwise specified (17 %), followed by Lennox-Gastaut syndrome (14.9 %). Regarding antiepileptic treatment, 51.1 % were receiving dual therapy and 21.3 % were on triple therapy. Additionally, 89.4 % had learning disorders and 85.1 % had intellectual disability. Among children over 3 years old, 37.5 % were not attending school. 19.1 % were hospitalized at least once in the past year, with an average hospitalization duration of 20.1 days. Conclusions: Drug-resistant epilepsy has a significant impact on the health and quality of life of children, creating a substantial burden on the healthcare system. Improving access to specialized treatments and comprehensive patient management is essential.
publishDate 2025
dc.date.none.fl_str_mv 2025-09-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.upch.edu.pe/index.php/RNP/article/view/6314
10.20453/rnp.v88i3.6314
url https://revistas.upch.edu.pe/index.php/RNP/article/view/6314
identifier_str_mv 10.20453/rnp.v88i3.6314
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistas.upch.edu.pe/index.php/RNP/article/view/6314/6670
dc.rights.none.fl_str_mv Derechos de autor 2025 Ivan Espinoza-Quinteros, Doris Liliana Rivera-Burgos
https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2025 Ivan Espinoza-Quinteros, Doris Liliana Rivera-Burgos
https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Peruana Cayetano Heredia
publisher.none.fl_str_mv Universidad Peruana Cayetano Heredia
dc.source.none.fl_str_mv Revista de Neuro-Psiquiatria; Vol. 88 No. 3 (2025): Julio-septiembre; 234-243
Revista de Neuro-Psiquiatría; Vol. 88 Núm. 3 (2025): Julio-septiembre; 234-243
Revista de Neuro-Psiquiatria; v. 88 n. 3 (2025): Julio-septiembre; 234-243
1609-7394
0034-8597
10.20453/rnp.v88i3
reponame:Revistas - Universidad Peruana Cayetano Heredia
instname:Universidad Peruana Cayetano Heredia
instacron:UPCH
instname_str Universidad Peruana Cayetano Heredia
instacron_str UPCH
institution UPCH
reponame_str Revistas - Universidad Peruana Cayetano Heredia
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repository.name.fl_str_mv
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spelling Drug-resistant epilepsy in children under 14 years: clinical and epidemiological characteristics at a tertiary hospital in Lima, PeruEpilepsia farmacorresistente en menores de 14 años: características clínicas y epidemiológicas en un hospital terciario de Lima, PerúEspinoza-Quinteros, IvanRivera-Burgos, Doris Lilianadrug resistant epilepsyantiepileptic drugketogenic dietepilepsy/surgerypediatricsepilepsia resistente a los medicamentosfármacos antiepilépticosdieta cetogénicaepilepsia/cirugíapediatríaObjective: To determine the frequency and clinical characteristics of children with drug-resistant epilepsy treated at a national hospital in Lima, Peru. Materials and methods: A prospective, case-series study was conducted on patients under 14 years of age with drug-resistant epilepsy, treated between October 2013 and March 2014. Drug resistance was defined as the persistence of seizures despite the use of at least two antiepileptic drug regimens at maximum tolerated doses. Data were collected through interviews with family members and a review of medical records. Results: Forty-six patients were enrolled, representing 26.0 % of children under 14 years of age treated for epilepsy. The mean age was 8.46 ± 3.55 years, with 42.6 % of patients being female. The median age at seizure onset was 10.3 months, and the average duration of epilepsy was 6.5 years. Most patients (66 %) had symptomatic or cryptogenic epilepsy, with brain malformations and postnatal infections being the most common causes (14.9 % each). A total of 17 % of the patients were diagnosed with idiopathic epilepsy. The most common types of epilepsy were focal epilepsy not otherwise specified (42.6 %) and generalized epilepsy not otherwise specified (17 %), followed by Lennox-Gastaut syndrome (14.9 %). Regarding antiepileptic treatment, 51.1 % were receiving dual therapy and 21.3 % were on triple therapy. Additionally, 89.4 % had learning disorders and 85.1 % had intellectual disability. Among children over 3 years old, 37.5 % were not attending school. 19.1 % were hospitalized at least once in the past year, with an average hospitalization duration of 20.1 days. Conclusions: Drug-resistant epilepsy has a significant impact on the health and quality of life of children, creating a substantial burden on the healthcare system. Improving access to specialized treatments and comprehensive patient management is essential.Objetivo: Determinar la frecuencia y las características clínicas de los niños con epilepsia farmacorresistente (EFR) atendidos en un hospital nacional de Lima, Perú. Materiales y métodos: Estudio prospectivo, tipo serie de casos, que incluyó a pacientes menores de 14 años con EFR atendidos entre octubre de 2013 y marzo de 2014. Se definió farmacorresistencia como la persistencia de crisis a pesar del uso de al menos dos esquemas antiepilépticos adecuados a dosis máximas toleradas. Resultados: Participaron 47 pacientes, que representa al 26,0 % de los niños menores de 14 años atendidos por epilepsia en el nosocomio en mención. La edad promedio fue de 8,46 ± 3,55 años, con un 42,6 % de pacientes de sexo femenino. La mediana de edad de inicio de crisis fue de 10,3 meses, y el tiempo promedio de evolución de la epilepsia fue de 6,5 años. El 66 % presentó epilepsias sintomáticas o criptogénicas, siendo las malformaciones cerebrales y las infecciones postnatales las causas más comunes (14,9 % cada una). El 17 % presentaba epilepsias de causa idiopática. Predominaron las epilepsias focales no especificadas (42,6 %) y las generalizadas no especificadas (17 %), seguidas por el síndrome de Lennox-Gastaut (14,9 %). El 51,1 % recibía tratamiento antiepiléptico doble; y el 21,3 %, triple. El 89,4 % presentaba trastornos de aprendizaje; y el 85,1 %, discapacidad intelectual. Además, el 37,5 % de los niños mayores de 3 años no asistía a la escuela. El 19,1 % fue hospitalizado al menos una vez en el último año, con una duración promedio de 20,1 días. Conclusión: La EFR tiene un fuerte impacto en la salud y calidad de vida de los niños, y representa una carga significativa para el sistema de salud. Por tanto, es necesario mejorar el acceso a tratamientos especializados y fomentar el manejo integral de los pacientes.Universidad Peruana Cayetano Heredia2025-09-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistas.upch.edu.pe/index.php/RNP/article/view/631410.20453/rnp.v88i3.6314Revista de Neuro-Psiquiatria; Vol. 88 No. 3 (2025): Julio-septiembre; 234-243Revista de Neuro-Psiquiatría; Vol. 88 Núm. 3 (2025): Julio-septiembre; 234-243Revista de Neuro-Psiquiatria; v. 88 n. 3 (2025): Julio-septiembre; 234-2431609-73940034-859710.20453/rnp.v88i3reponame:Revistas - Universidad Peruana Cayetano Herediainstname:Universidad Peruana Cayetano Herediainstacron:UPCHspahttps://revistas.upch.edu.pe/index.php/RNP/article/view/6314/6670Derechos de autor 2025 Ivan Espinoza-Quinteros, Doris Liliana Rivera-Burgoshttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessoai:revistas.upch.edu.pe:article/63142025-09-25T21:32:59Z
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