Pharmacological treatment of epilepsy in elderly people, a literature review.

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Elderly people are at a higher risk of developing epilepsy. With a progressive increase in life expectancy, this is the fastest growing group of epilepsy patients. Their treatment is complicated by the presence of physiological changes related to aging, comorbidities, concomitant cognitive problems,...

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Detalles Bibliográficos
Autor: Bombón-Albán, Paulina E.
Formato: artículo
Fecha de Publicación:2022
Institución:Universidad Peruana Cayetano Heredia
Repositorio:Revistas - Universidad Peruana Cayetano Heredia
Lenguaje:español
OAI Identifier:oai:revistas.upch.edu.pe:article/4155
Enlace del recurso:https://revistas.upch.edu.pe/index.php/RNP/article/view/4155
Nivel de acceso:acceso abierto
Materia:Elderly people
epilepsy
epileptic seizure drug
, treatment
Adulto mayor
epilepsia
fármacos anticrisis antiepiléptica
tratamiento
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network_name_str Revistas - Universidad Peruana Cayetano Heredia
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dc.title.none.fl_str_mv Pharmacological treatment of epilepsy in elderly people, a literature review.
Tratamiento farmacológico de la epilepsia en el adulto mayor, revisión de la literatura.
title Pharmacological treatment of epilepsy in elderly people, a literature review.
spellingShingle Pharmacological treatment of epilepsy in elderly people, a literature review.
Bombón-Albán, Paulina E.
Elderly people
epilepsy
epileptic seizure drug
, treatment
Adulto mayor
epilepsia
fármacos anticrisis antiepiléptica
tratamiento
title_short Pharmacological treatment of epilepsy in elderly people, a literature review.
title_full Pharmacological treatment of epilepsy in elderly people, a literature review.
title_fullStr Pharmacological treatment of epilepsy in elderly people, a literature review.
title_full_unstemmed Pharmacological treatment of epilepsy in elderly people, a literature review.
title_sort Pharmacological treatment of epilepsy in elderly people, a literature review.
dc.creator.none.fl_str_mv Bombón-Albán, Paulina E.
author Bombón-Albán, Paulina E.
author_facet Bombón-Albán, Paulina E.
author_role author
dc.subject.none.fl_str_mv Elderly people
epilepsy
epileptic seizure drug
, treatment
Adulto mayor
epilepsia
fármacos anticrisis antiepiléptica
tratamiento
topic Elderly people
epilepsy
epileptic seizure drug
, treatment
Adulto mayor
epilepsia
fármacos anticrisis antiepiléptica
tratamiento
description Elderly people are at a higher risk of developing epilepsy. With a progressive increase in life expectancy, this is the fastest growing group of epilepsy patients. Their treatment is complicated by the presence of physiological changes related to aging, comorbidities, concomitant cognitive problems, complex drug interactions, and difficulties in the adherence to medication regimes. Seizures can be controlled in elderly people patients with low doses of a single epileptic seizure drug. Tolerability is an important factor in drug selection, as elderly people patients tend to be very sensitive to side effects. Enzyme-inducing anti-seizure drugs should gradually be left out of the therapeutic arsenal in favor of new anti-seizure drugs that have shown similar efficacy and better tolerability. Levetiracetam and lamotrigine are the most recommended anti-seizure drugs for elderly people with epilepsy nowadays. Although it could be easily controlled, it is recommended that elderly people continue their treatment indefinitely, due to the recurrent seizures’ proclivity. More studies are needed to address the pathophysiological mechanisms of epilepsy in this age group, and greater inclusion of elderly people in clinical trials is needed, as is the development of comprehensive care models to provide optimal patient care.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-21
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.upch.edu.pe/index.php/RNP/article/view/4155
10.20453/rnp.v85i1.4155
url https://revistas.upch.edu.pe/index.php/RNP/article/view/4155
identifier_str_mv 10.20453/rnp.v85i1.4155
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistas.upch.edu.pe/index.php/RNP/article/view/4155/4699
https://revistas.upch.edu.pe/index.php/RNP/article/view/4155/4824
dc.rights.none.fl_str_mv Derechos de autor 2022 Fernando Ardito; Paulina E. Bombón-Albán
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2022 Fernando Ardito; Paulina E. Bombón-Albán
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Universidad Peruana Cayetano Heredia
publisher.none.fl_str_mv Universidad Peruana Cayetano Heredia
dc.source.none.fl_str_mv Revista de Neuro-Psiquiatria; Vol. 85 No. 1 (2022): January-March; 55-65
Revista de Neuro-Psiquiatría; Vol. 85 Núm. 1 (2022): Enero-Marzo; 55-65
Revista de Neuro-Psiquiatria; v. 85 n. 1 (2022): Enero-Marzo; 55-65
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spelling Pharmacological treatment of epilepsy in elderly people, a literature review.Tratamiento farmacológico de la epilepsia en el adulto mayor, revisión de la literatura.Bombón-Albán, Paulina E.Elderly peopleepilepsyepileptic seizure drug, treatmentAdulto mayorepilepsiafármacos anticrisis antiepilépticatratamientoElderly people are at a higher risk of developing epilepsy. With a progressive increase in life expectancy, this is the fastest growing group of epilepsy patients. Their treatment is complicated by the presence of physiological changes related to aging, comorbidities, concomitant cognitive problems, complex drug interactions, and difficulties in the adherence to medication regimes. Seizures can be controlled in elderly people patients with low doses of a single epileptic seizure drug. Tolerability is an important factor in drug selection, as elderly people patients tend to be very sensitive to side effects. Enzyme-inducing anti-seizure drugs should gradually be left out of the therapeutic arsenal in favor of new anti-seizure drugs that have shown similar efficacy and better tolerability. Levetiracetam and lamotrigine are the most recommended anti-seizure drugs for elderly people with epilepsy nowadays. Although it could be easily controlled, it is recommended that elderly people continue their treatment indefinitely, due to the recurrent seizures’ proclivity. More studies are needed to address the pathophysiological mechanisms of epilepsy in this age group, and greater inclusion of elderly people in clinical trials is needed, as is the development of comprehensive care models to provide optimal patient care.Los adultos mayores tienen mayor riesgo de desarrollar epilepsia. Con un aumento progresivo de la expectativa de vida, este grupo muestra el más rápido incremento entre los pacientes con epilepsia. El tratamiento en sí se complica debido a los cambios fisiológicos relacionados con el envejecimiento, las comorbilidades, los problemas cognitivos concomitantes, las interacciones farmacológicas complejas y las dificultades en la adherencia a regímenes medicamentosos. Las crisis epilépticas se pueden controlar en la mayoría de los pacientes adultos mayores con dosis bajas de un solo fármaco anticrisis epiléptica de efecto específico. La tolerabilidad es un factor importante en la selección del fármaco, ya que los pacientes adultos mayores tienden a ser muy sensibles a los efectos secundarios. Los fármacos anticrisis epiléptica que operan como inductores enzimáticos debe valorarse su retiro del arsenal terapéutico en favor de nuevos agentes que han demostrado similar eficacia y mejor tolerabilidad. Lamotrigina y levetiracetam son los fármacos anticrisis epiléptica más recomendados actualmente para el manejo de este cuadro en los adultos mayores. Aun cuando puede tratarse de una epilepsia fácilmente controlable, es recomendable mantener el tratamiento de forma indefinida en los adultos mayores dada la tendencia recurrente de las crisis. Se requieren más estudios que aborden los mecanismos fisiopatológicos de la epilepsia en este grupo etario y una mayor inclusión de los adultos mayores en ensayos clínicos, así como el desarrollo de modelos de atención integral que optimice el cuidado de estos pacientes.Universidad Peruana Cayetano Heredia2022-03-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistas.upch.edu.pe/index.php/RNP/article/view/415510.20453/rnp.v85i1.4155Revista de Neuro-Psiquiatria; Vol. 85 No. 1 (2022): January-March; 55-65Revista de Neuro-Psiquiatría; Vol. 85 Núm. 1 (2022): Enero-Marzo; 55-65Revista de Neuro-Psiquiatria; v. 85 n. 1 (2022): Enero-Marzo; 55-651609-73940034-8597reponame:Revistas - Universidad Peruana Cayetano Herediainstname:Universidad Peruana Cayetano Herediainstacron:UPCHspahttps://revistas.upch.edu.pe/index.php/RNP/article/view/4155/4699https://revistas.upch.edu.pe/index.php/RNP/article/view/4155/4824Derechos de autor 2022 Fernando Ardito; Paulina E. Bombón-Albáninfo:eu-repo/semantics/openAccessoai:revistas.upch.edu.pe:article/41552023-08-08T17:11:05Z
score 12.783859
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