Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer

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Resistance to third-generation tyrosine kinase inhibitors (TKI) is an increasingly frequent event in clinical practice; however, the exact mechanisms by which tumor cells develop such resistance allowing their survival are unknown. A case of resistance to osimertinib (AZD9291) in non small cell lung...

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Detalles Bibliográficos
Autores: Runciman Gozzer, Thanya, Carracedo Gonzáles, Carlos
Formato: artículo
Fecha de Publicación:2018
Institución:Universidad Nacional Mayor de San Marcos
Repositorio:Revistas - Universidad Nacional Mayor de San Marcos
Lenguaje:español
OAI Identifier:oai:revistasinvestigacion.unmsm.edu.pe:article/15639
Enlace del recurso:https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/15639
Nivel de acceso:acceso abierto
Materia:Drug Resistance
Tyrosine
Lung Neoplasms
Resistencia a medicamentos
Tirosina
Neoplasia Pulmonar
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spelling Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancerResistencia adquirida a inhibidores de tirosina kinasa de tercera generación en cáncer de pulmón de células no pequeñasRunciman Gozzer, ThanyaCarracedo Gonzáles, CarlosDrug ResistanceTyrosineLung NeoplasmsResistencia a medicamentosTirosinaNeoplasia PulmonarResistance to third-generation tyrosine kinase inhibitors (TKI) is an increasingly frequent event in clinical practice; however, the exact mechanisms by which tumor cells develop such resistance allowing their survival are unknown. A case of resistance to osimertinib (AZD9291) in non small cell lung cancer, evidenced by next generation sequencing (NGS) and its possible therapeutic approach is described.La resistencia a inhibidores de tirosina kinasa (TKI) de tercera generación son un evento cada vez más frecuente en la práctica clínica, a pesar de ello, se desconoce aún los mecanismos exactos mediante los cuales las células tumorales desarrollan dicha resistencia permitiendo sus supervivencia. Se describe un caso de resistencia a osimertinib (AZD9291) en cáncer de pulmón de celulas no pequeñas, evidenciado por secuenciamiento genético (NGS) y su posible planteamiento terapéutico.Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana2018-12-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/1563910.15381/anales.v79i4.15639Anales de la Facultad de Medicina; Vol. 79 No. 4 (2018); 327-330Anales de la Facultad de Medicina; Vol. 79 Núm. 4 (2018); 327-3301609-94191025-5583reponame:Revistas - Universidad Nacional Mayor de San Marcosinstname:Universidad Nacional Mayor de San Marcosinstacron:UNMSMspahttps://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/15639/13431Derechos de autor 2018 Anales de la Facultad de Medicinahttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessoai:revistasinvestigacion.unmsm.edu.pe:article/156392019-01-18T09:35:14Z
dc.title.none.fl_str_mv Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer
Resistencia adquirida a inhibidores de tirosina kinasa de tercera generación en cáncer de pulmón de células no pequeñas
title Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer
spellingShingle Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer
Runciman Gozzer, Thanya
Drug Resistance
Tyrosine
Lung Neoplasms
Resistencia a medicamentos
Tirosina
Neoplasia Pulmonar
title_short Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer
title_full Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer
title_fullStr Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer
title_full_unstemmed Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer
title_sort Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer
dc.creator.none.fl_str_mv Runciman Gozzer, Thanya
Carracedo Gonzáles, Carlos
author Runciman Gozzer, Thanya
author_facet Runciman Gozzer, Thanya
Carracedo Gonzáles, Carlos
author_role author
author2 Carracedo Gonzáles, Carlos
author2_role author
dc.subject.none.fl_str_mv Drug Resistance
Tyrosine
Lung Neoplasms
Resistencia a medicamentos
Tirosina
Neoplasia Pulmonar
topic Drug Resistance
Tyrosine
Lung Neoplasms
Resistencia a medicamentos
Tirosina
Neoplasia Pulmonar
description Resistance to third-generation tyrosine kinase inhibitors (TKI) is an increasingly frequent event in clinical practice; however, the exact mechanisms by which tumor cells develop such resistance allowing their survival are unknown. A case of resistance to osimertinib (AZD9291) in non small cell lung cancer, evidenced by next generation sequencing (NGS) and its possible therapeutic approach is described.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-30
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/15639
10.15381/anales.v79i4.15639
url https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/15639
identifier_str_mv 10.15381/anales.v79i4.15639
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/15639/13431
dc.rights.none.fl_str_mv Derechos de autor 2018 Anales de la Facultad de Medicina
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2018 Anales de la Facultad de Medicina
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana
publisher.none.fl_str_mv Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana
dc.source.none.fl_str_mv Anales de la Facultad de Medicina; Vol. 79 No. 4 (2018); 327-330
Anales de la Facultad de Medicina; Vol. 79 Núm. 4 (2018); 327-330
1609-9419
1025-5583
reponame:Revistas - Universidad Nacional Mayor de San Marcos
instname:Universidad Nacional Mayor de San Marcos
instacron:UNMSM
instname_str Universidad Nacional Mayor de San Marcos
instacron_str UNMSM
institution UNMSM
reponame_str Revistas - Universidad Nacional Mayor de San Marcos
collection Revistas - Universidad Nacional Mayor de San Marcos
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 13.861517
Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancer
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