Insulin resistance in euthyroid women with thyroid nodules: case-control study

• Autores: Albitres-Gamarra, Andrés, Pando-Álvarez, Rosa, Castillo-Visa, Elizabeth
• Formato: artículo
• Fecha de Publicación: 2021
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:revistasinvestigacion.unmsm.edu.pe:article/20249
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/20249
• Nivel de acceso: acceso abierto
• Materia: Nódulo Tiroideo; Resistencia a la Insulina; Mujeres; Yodo; Thyroid Nodule; Insulin Resistance; Women; Iodine

Objective. To establish the association between insulin resistance and thyroid nodules in euthyroid women from Metropolitan Lima. Methods. Study in euthyroid women, 20 to 70 years of age: 32 cases (with thyroid nodules) and 32 controls (without thyroid nodules), by ultrasound of the thyroid, negative anti-thyroid antibodies, and adequate urinary iodine excretion (EUI), matched by age and BMI, treated in the Almenara-EsSalud care network. Using a clinical record, age and anthropometric parameters were recorded. Was measured: glucose, basal insulin (IB), and insulin resistance (IR) using the homeostatic model (HOMAIR≥2.97). EUI was detected by spectrophotometer at 420 nm, it was considered adequate between 100-300 ug/L. For the statistical analysis, the student’s t-test, Chi-square test, Fisher’s exact test, and Odds Ratio adjusted for age and abdominal obesity were used, considering a statistically significant p <0.05. Results: Significant differences were observed in the means between the group of cases and controls in fasting glucose, IB, HOMA-IR (4.3 vs 2.5, p <0.05), and EUI levels were lower in the group of cases (167.2 vs 228.3 ug/L p <0.001). IR was more frequent in the case group than in the control group (82.3% vs 28.1%; p <0.001). The Odds Ratio was 14.8 (95% CI: 3.4-65.1). Conclusion: In this study, a significant association was found between the presence of thyroid nodules and insulin resistance in euthyroid adult women residing in an iodine-sufficient region.