Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats
Descripción del Articulo
OBJECTIVE: The gastric protective abilities of dried sap and alkaloid fraction of Croton palanostigma and sucralfate against ethanol-induced necrosis was compared by means of standard experimental rat model. Subchronic toxicity was determined. MATERIAL AND METHODS: A pretreatment with either saline...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2001 |
| Institución: | Universidad Nacional Mayor de San Marcos |
| Repositorio: | Revistas - Universidad Nacional Mayor de San Marcos |
| Lenguaje: | español |
| OAI Identifier: | oai:ojs.csi.unmsm:article/4205 |
| Enlace del recurso: | https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4205 |
| Nivel de acceso: | acceso abierto |
| Materia: | Gastric mucosa Plants medicinal Anti-ulcer agents Disease models animal Mucosa gástrica Plantas medicinales Agentes antiulcerosos Modelos animales de enfermedad |
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Revistas - Universidad Nacional Mayor de San Marcos |
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Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in ratsEfecto protector de látex desecado y fracción alcaloidea de Croton palanostigma frente a injuria de mucosa gástrica inducida por etanol en ratasAyala Pío, SalomónJurupe, HildaDíaz, DavidLock, OlgaVega, MaríaLuque, JorgeGarnique, MarcoGastric mucosaPlantsmedicinalAnti-ulcer agentsDisease modelsanimalMucosa gástricaPlantas medicinalesAgentes antiulcerososModelos animales de enfermedadOBJECTIVE: The gastric protective abilities of dried sap and alkaloid fraction of Croton palanostigma and sucralfate against ethanol-induced necrosis was compared by means of standard experimental rat model. Subchronic toxicity was determined. MATERIAL AND METHODS: A pretreatment with either saline solution, dried sap of C. palanostigma 120 mg/kg, alkaloid fraction of C. palanostigma 20 mg/kg, 35 mg/kg y 50 mg/kg or sucralfate was given to 60 rats. Intragastric administration of 2 mL of 100% ethanol was accomplished one hour later. A gastrectomy was perfomed four hours later followed by macroscopic and histological evaluation of the gastric lesions. Subchronic toxicity was determined with doses of 0,12, 0,40 and 1,20 mL/kg of sap for a 30-day period with biochemical and histopathologic study of the organs. RESULTS: Pretreatment with dried sap and alkaloid fractions of C. palanostigma and sucralfate resulted in a significant reduction of ethanol-induced gastric mucosa necrosis. Subchronic toxicity with C. palanostigma largest dose showed risk of liver steatosis. CONCLUSION: In the present study, dried sap and alkaloid fraction of C. palanostigma and sucralfate showed a significative protective effect, being potentially useful as a therapeutic tool. Subchronic toxicity in higher doses showed risk of liver steatosis.OBJETIVOS: Evaluar el grado de protección de necrosis de la mucosa gástrica por etanol, con látex desecado y fracciones alcaloideas de C. palanostigma, en un modelo experimental estandarizado en ratas. Evaluar toxicidad subcrónica. MATERIAL Y MÉTODOS: Se evaluó 60 animales, administrándoles uno de 6 pretratamientos: solución salina, látex desecado de C. palanostigma 120 mg/kg, fracción alcaloidea de C. palanostigma 20 mg/kg, 35 mg/kg y 50 mg/kg y sucralfato 500 mg/kg. Una hora más tarde se aplicó por vía intragástrica 2 mL de etanol al 100%. Se realizó evaluación macroscópica y microscópica de las lesiones gástricas. Se evaluó la toxicidad subcrónica a la dosis de 0,12, 0,40 y 1,20 mL/kg, por el período de 30 días, con estudios bioquímicos e histopatológicos de los órganos. RESULTADOS: El pretratamiento con látex y las fracciones alcaloideas y el sucralfato redujo significativamente la necrosis hemorrágica inducida por el etanol. La toxicidad subcrónica en la dosis mayor mostró riesgo de esteatosis hepática. CONCLUSIÓN: En nuestras condiciones experimentales el C. palanostigma y la taspina presentaron importante efecto protector y potencial terapéutico. En toxicidad subcrónica, la dosis mayor presentó riesgo de esteatosis hepática.Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana2001-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/420510.15381/anales.v62i4.4205Anales de la Facultad de Medicina; Vol. 62 No. 4 (2001); 317-324Anales de la Facultad de Medicina; Vol. 62 Núm. 4 (2001); 317-3241609-94191025-5583reponame:Revistas - Universidad Nacional Mayor de San Marcosinstname:Universidad Nacional Mayor de San Marcosinstacron:UNMSMspahttps://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4205/3359Derechos de autor 2001 Salomón Ayala Pío, Hilda Jurupe, David Díaz, Olga Lock, María Vega, Jorge Luque, Marco Garniquehttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessoai:ojs.csi.unmsm:article/42052020-04-14T18:34:58Z |
| dc.title.none.fl_str_mv |
Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats Efecto protector de látex desecado y fracción alcaloidea de Croton palanostigma frente a injuria de mucosa gástrica inducida por etanol en ratas |
| title |
Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats |
| spellingShingle |
Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats Ayala Pío, Salomón Gastric mucosa Plants medicinal Anti-ulcer agents Disease models animal Mucosa gástrica Plantas medicinales Agentes antiulcerosos Modelos animales de enfermedad |
| title_short |
Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats |
| title_full |
Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats |
| title_fullStr |
Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats |
| title_full_unstemmed |
Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats |
| title_sort |
Protective effect of dried latex and alkaloid fraction of Croton palanostigma against gastric mucosal injury induced by ethanol in rats |
| dc.creator.none.fl_str_mv |
Ayala Pío, Salomón Jurupe, Hilda Díaz, David Lock, Olga Vega, María Luque, Jorge Garnique, Marco |
| author |
Ayala Pío, Salomón |
| author_facet |
Ayala Pío, Salomón Jurupe, Hilda Díaz, David Lock, Olga Vega, María Luque, Jorge Garnique, Marco |
| author_role |
author |
| author2 |
Jurupe, Hilda Díaz, David Lock, Olga Vega, María Luque, Jorge Garnique, Marco |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Gastric mucosa Plants medicinal Anti-ulcer agents Disease models animal Mucosa gástrica Plantas medicinales Agentes antiulcerosos Modelos animales de enfermedad |
| topic |
Gastric mucosa Plants medicinal Anti-ulcer agents Disease models animal Mucosa gástrica Plantas medicinales Agentes antiulcerosos Modelos animales de enfermedad |
| description |
OBJECTIVE: The gastric protective abilities of dried sap and alkaloid fraction of Croton palanostigma and sucralfate against ethanol-induced necrosis was compared by means of standard experimental rat model. Subchronic toxicity was determined. MATERIAL AND METHODS: A pretreatment with either saline solution, dried sap of C. palanostigma 120 mg/kg, alkaloid fraction of C. palanostigma 20 mg/kg, 35 mg/kg y 50 mg/kg or sucralfate was given to 60 rats. Intragastric administration of 2 mL of 100% ethanol was accomplished one hour later. A gastrectomy was perfomed four hours later followed by macroscopic and histological evaluation of the gastric lesions. Subchronic toxicity was determined with doses of 0,12, 0,40 and 1,20 mL/kg of sap for a 30-day period with biochemical and histopathologic study of the organs. RESULTS: Pretreatment with dried sap and alkaloid fractions of C. palanostigma and sucralfate resulted in a significant reduction of ethanol-induced gastric mucosa necrosis. Subchronic toxicity with C. palanostigma largest dose showed risk of liver steatosis. CONCLUSION: In the present study, dried sap and alkaloid fraction of C. palanostigma and sucralfate showed a significative protective effect, being potentially useful as a therapeutic tool. Subchronic toxicity in higher doses showed risk of liver steatosis. |
| publishDate |
2001 |
| dc.date.none.fl_str_mv |
2001-12-31 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4205 10.15381/anales.v62i4.4205 |
| url |
https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4205 |
| identifier_str_mv |
10.15381/anales.v62i4.4205 |
| dc.language.none.fl_str_mv |
spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/4205/3359 |
| dc.rights.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana |
| publisher.none.fl_str_mv |
Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana |
| dc.source.none.fl_str_mv |
Anales de la Facultad de Medicina; Vol. 62 No. 4 (2001); 317-324 Anales de la Facultad de Medicina; Vol. 62 Núm. 4 (2001); 317-324 1609-9419 1025-5583 reponame:Revistas - Universidad Nacional Mayor de San Marcos instname:Universidad Nacional Mayor de San Marcos instacron:UNMSM |
| instname_str |
Universidad Nacional Mayor de San Marcos |
| instacron_str |
UNMSM |
| institution |
UNMSM |
| reponame_str |
Revistas - Universidad Nacional Mayor de San Marcos |
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Revistas - Universidad Nacional Mayor de San Marcos |
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1795238245397692416 |
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13.887938 |
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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
