Effect of platelet-rich plasma on skin flaps in rabbits

Descripción del Articulo

Autologous platelet concentrates (APC) has been used as an accelerator of cutaneous healing in veterinary medicine. The aim of this study was to evaluate the effect of an APC on skin flaps in rabbits (Oryctolagus cuniculus). Ten New Zealand male rabbits were randomly divided into a control group and...

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Detalles Bibliográficos
Autores: Aragón-Urrego, Catherine, Barbosa, Irma Ximena, Aristizabal, Omar Leonardo
Formato: artículo
Fecha de Publicación:2018
Institución:Universidad Nacional Mayor de San Marcos
Repositorio:Revistas - Universidad Nacional Mayor de San Marcos
Lenguaje:español
OAI Identifier:oai:ojs.csi.unmsm:article/15351
Enlace del recurso:https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/15351
Nivel de acceso:acceso abierto
Materia:rabbit
autologous platelets concentrate
skin flap
wound healing
conejo
concentrado autólogo de plaquetas
colgajo cutáneo
cicatrización de heridas
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spelling Effect of platelet-rich plasma on skin flaps in rabbitsEfecto de un concentrado autólogo de plaquetas en colgajos cutáneos en conejosAragón-Urrego, CatherineBarbosa, Irma XimenaAristizabal, Omar Leonardorabbitautologous platelets concentrateskin flapwound healingconejoconcentrado autólogo de plaquetascolgajo cutáneocicatrización de heridasAutologous platelet concentrates (APC) has been used as an accelerator of cutaneous healing in veterinary medicine. The aim of this study was to evaluate the effect of an APC on skin flaps in rabbits (Oryctolagus cuniculus). Ten New Zealand male rabbits were randomly divided into a control group and an APC group. A rotating cutaneous flap was made in the thoraco-dorsal region of the right thoracic limb of the rabbits. Half of the rabbits received APC infiltrated under the flap. Biopsies were taken from the union of the flap with the recipient bed at 3, 7, 14, and 21 days post-surgery. The histological analysis of the inflammatory infiltrate was made, and the proliferation of fibroblasts and type of collagen formed was determined. A significant difference was observed in the neutrophil count, macrophages and fibroblasts. The histological analysis showed that a single application of CAP does not reduce the healing time in skin flaps; however, it promotes the formation of blood vessels and reduces the inflammatory infiltrate in rabbits throughout experimental time.El concentrado autólogo de plaquetas (CAP) ha sido utilizado como acelerador de la cicatrización cutánea en medicina veterinaria. El objetivo del presente trabajo fue evaluar el efecto de un CAP en colgajos cutáneos en conejos (Oryctolagus cuniculus). Se utilizaron 10 conejos machos Nueva Zelanda divididos aleatoriamente en un grupo control y un grupo CAP. Se hizo un colgajo cutáneo de rotación en la región toraco-dorsal del miembro torácico derecho de los conejos. La mitad de los conejos recibieron CAP infiltrado bajo el colgajo. Se tomaron biopsias de la unión del colgajo con el lecho receptor a los 3, 7, 14 y 21 días posquirúrgico. Se hizo el análisis histológico del infiltrado inflamatorio y se determinó la proliferación de fibroblastos y tipo de colágeno formado. Se observó diferencia significativa en el recuento de neutrófilos, macrófagos y fibroblastos. El análisis histológico demostró que una única aplicación de CAP no reduce el tiempo de cicatrización en colgajos cutáneos; sin embargo, promueve la formación de vasos sanguíneos y reduce el infiltrado inflamatorio en conejos a lo largo del tiempo experimental.Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria2018-11-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/1535110.15381/rivep.v29i4.15351Revista de Investigaciones Veterinarias del Perú; Vol. 29 Núm. 4 (2018); 1184-1194Revista de Investigaciones Veterinarias del Perú; Vol. 29 No. 4 (2018); 1184-11941682-34191609-9117reponame:Revistas - Universidad Nacional Mayor de San Marcosinstname:Universidad Nacional Mayor de San Marcosinstacron:UNMSMspahttps://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/15351/13287https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/15351/13810Derechos de autor 2018 Catherine Aragón-Urrego, Irma Ximena Barbosa, Omar Leonardo Aristizabalhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessoai:ojs.csi.unmsm:article/153512018-11-26T18:06:04Z
dc.title.none.fl_str_mv Effect of platelet-rich plasma on skin flaps in rabbits
Efecto de un concentrado autólogo de plaquetas en colgajos cutáneos en conejos
title Effect of platelet-rich plasma on skin flaps in rabbits
spellingShingle Effect of platelet-rich plasma on skin flaps in rabbits
Aragón-Urrego, Catherine
rabbit
autologous platelets concentrate
skin flap
wound healing
conejo
concentrado autólogo de plaquetas
colgajo cutáneo
cicatrización de heridas
title_short Effect of platelet-rich plasma on skin flaps in rabbits
title_full Effect of platelet-rich plasma on skin flaps in rabbits
title_fullStr Effect of platelet-rich plasma on skin flaps in rabbits
title_full_unstemmed Effect of platelet-rich plasma on skin flaps in rabbits
title_sort Effect of platelet-rich plasma on skin flaps in rabbits
dc.creator.none.fl_str_mv Aragón-Urrego, Catherine
Barbosa, Irma Ximena
Aristizabal, Omar Leonardo
author Aragón-Urrego, Catherine
author_facet Aragón-Urrego, Catherine
Barbosa, Irma Ximena
Aristizabal, Omar Leonardo
author_role author
author2 Barbosa, Irma Ximena
Aristizabal, Omar Leonardo
author2_role author
author
dc.subject.none.fl_str_mv rabbit
autologous platelets concentrate
skin flap
wound healing
conejo
concentrado autólogo de plaquetas
colgajo cutáneo
cicatrización de heridas
topic rabbit
autologous platelets concentrate
skin flap
wound healing
conejo
concentrado autólogo de plaquetas
colgajo cutáneo
cicatrización de heridas
description Autologous platelet concentrates (APC) has been used as an accelerator of cutaneous healing in veterinary medicine. The aim of this study was to evaluate the effect of an APC on skin flaps in rabbits (Oryctolagus cuniculus). Ten New Zealand male rabbits were randomly divided into a control group and an APC group. A rotating cutaneous flap was made in the thoraco-dorsal region of the right thoracic limb of the rabbits. Half of the rabbits received APC infiltrated under the flap. Biopsies were taken from the union of the flap with the recipient bed at 3, 7, 14, and 21 days post-surgery. The histological analysis of the inflammatory infiltrate was made, and the proliferation of fibroblasts and type of collagen formed was determined. A significant difference was observed in the neutrophil count, macrophages and fibroblasts. The histological analysis showed that a single application of CAP does not reduce the healing time in skin flaps; however, it promotes the formation of blood vessels and reduces the inflammatory infiltrate in rabbits throughout experimental time.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-25
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/15351
10.15381/rivep.v29i4.15351
url https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/15351
identifier_str_mv 10.15381/rivep.v29i4.15351
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/15351/13287
https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/15351/13810
dc.rights.none.fl_str_mv Derechos de autor 2018 Catherine Aragón-Urrego, Irma Ximena Barbosa, Omar Leonardo Aristizabal
https://creativecommons.org/licenses/by-nc-sa/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2018 Catherine Aragón-Urrego, Irma Ximena Barbosa, Omar Leonardo Aristizabal
https://creativecommons.org/licenses/by-nc-sa/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria
publisher.none.fl_str_mv Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria
dc.source.none.fl_str_mv Revista de Investigaciones Veterinarias del Perú; Vol. 29 Núm. 4 (2018); 1184-1194
Revista de Investigaciones Veterinarias del Perú; Vol. 29 No. 4 (2018); 1184-1194
1682-3419
1609-9117
reponame:Revistas - Universidad Nacional Mayor de San Marcos
instname:Universidad Nacional Mayor de San Marcos
instacron:UNMSM
instname_str Universidad Nacional Mayor de San Marcos
instacron_str UNMSM
institution UNMSM
reponame_str Revistas - Universidad Nacional Mayor de San Marcos
collection Revistas - Universidad Nacional Mayor de San Marcos
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 13.882472
Effect of platelet-rich plasma on skin flaps in rabbits
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