Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex
Descripción del Articulo
Cytogenetic biomonitoring techniques allow early detection of exposure to genotoxic agents and the sister chromatid exchange assay (SCE) that was applied aimed to evaluate these effects in peripheral blood lymphocytes of health personnel exposed to antineoplastic drugs in a Hospital Complex of Lima....
| Autores: | , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2022 |
| Institución: | Universidad Nacional Mayor de San Marcos |
| Repositorio: | Revistas - Universidad Nacional Mayor de San Marcos |
| Lenguaje: | español |
| OAI Identifier: | oai:ojs.csi.unmsm:article/22521 |
| Enlace del recurso: | https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/22521 |
| Nivel de acceso: | acceso abierto |
| Materia: | sister chromatid exchange antineoplastic drugs occupational risk healthcare personnel genotoxicity Intercambio de cromátidas hermanas antineoplásicos riesgo laboral personal sanitario genotoxicidad |
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Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complexIntercambio de cromátidas hermanas en personal sanitario expuesto a medicamentos antineoplásicos en un complejo hospitalario de LimaCruz-Bueza, FredyInostroza-Ruiz, LuisCórdova-Ramos, JavierCruz-Bueza, FredyInostroza-Ruiz, LuisCórdova-Ramos, Javiersister chromatid exchangeantineoplastic drugsoccupational riskhealthcare personnelgenotoxicityIntercambio de cromátidas hermanasantineoplásicosriesgo laboralpersonal sanitariogenotoxicidadCytogenetic biomonitoring techniques allow early detection of exposure to genotoxic agents and the sister chromatid exchange assay (SCE) that was applied aimed to evaluate these effects in peripheral blood lymphocytes of health personnel exposed to antineoplastic drugs in a Hospital Complex of Lima. The exposed group was subdivided according to the proximity to the oncological preparations in: direct, intermediate and low contact, in addition there was a control group. The information was analyzed in the statistical program IBM SPSS 25.0. Statistically significant differences were found in the frequencies of exchanges in the groups of health personnel with direct and intermediate exposure compared to the control group (P<0.05), the comparative analysis between personnel with leave and the control group did not show significant differences. These findings allow evidence of a higher risk of genotoxicity for health personnel exposed to antineoplastic drugs.Las técnicas citogenéticas de biomonitoreo permiten la detección temprana de la exposición a los agentes genotóxicos y el ensayo de intercambio de cromátidas hermanas (ICH) que se aplicó tuvo como objetivo evaluar estos efectos en linfocitos de sangre periférica del personal sanitario expuesto a medicamentos antineoplásicos en un Complejo Hospitalario de Lima. El grupo expuesto se subdividió de acuerdo con la cercanía a los preparados oncológicos en: contacto directo, intermedio y bajo, además se tuvo un grupo control. La información fue analizada en el programa estadístico IBM SPSS 25.0. Se hallaron diferencias estadísticamente significativas en las frecuencias de intercambios en los grupos de personal sanitario con exposición directa e intermedia comparados con el grupo control (P<0.05), el análisis comparativo entre el personal con exposición baja y el grupo control no evidenció diferencias significativas. Estos hallazgos permiten evidenciar mayor riesgo de genotoxicidad para el personal sanitario expuesto a medicamentos antineoplásicos.Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquímica2022-03-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/2252110.15381/ci.v24i2.22521Ciencia e Investigación; Vol. 24 Núm. 2 (2021); 15-20Ciencia e Investigación; Vol. 24 No. 2 (2021); 15-201609-90441561-0861reponame:Revistas - Universidad Nacional Mayor de San Marcosinstname:Universidad Nacional Mayor de San Marcosinstacron:UNMSMspahttps://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/22521/18038Derechos de autor 2022 Fredy Cruz-Bueza, Luis Inostroza-Ruiz, Javier Córdova-Ramoshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:ojs.csi.unmsm:article/225212022-03-29T15:33:56Z |
| dc.title.none.fl_str_mv |
Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex Intercambio de cromátidas hermanas en personal sanitario expuesto a medicamentos antineoplásicos en un complejo hospitalario de Lima |
| title |
Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex |
| spellingShingle |
Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex Cruz-Bueza, Fredy sister chromatid exchange antineoplastic drugs occupational risk healthcare personnel genotoxicity Intercambio de cromátidas hermanas antineoplásicos riesgo laboral personal sanitario genotoxicidad |
| title_short |
Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex |
| title_full |
Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex |
| title_fullStr |
Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex |
| title_full_unstemmed |
Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex |
| title_sort |
Sister chromatid exchange in healthcare personnel exposed to antineoplastic drugs in a Lima hospital complex |
| dc.creator.none.fl_str_mv |
Cruz-Bueza, Fredy Inostroza-Ruiz, Luis Córdova-Ramos, Javier Cruz-Bueza, Fredy Inostroza-Ruiz, Luis Córdova-Ramos, Javier |
| author |
Cruz-Bueza, Fredy |
| author_facet |
Cruz-Bueza, Fredy Inostroza-Ruiz, Luis Córdova-Ramos, Javier |
| author_role |
author |
| author2 |
Inostroza-Ruiz, Luis Córdova-Ramos, Javier |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
sister chromatid exchange antineoplastic drugs occupational risk healthcare personnel genotoxicity Intercambio de cromátidas hermanas antineoplásicos riesgo laboral personal sanitario genotoxicidad |
| topic |
sister chromatid exchange antineoplastic drugs occupational risk healthcare personnel genotoxicity Intercambio de cromátidas hermanas antineoplásicos riesgo laboral personal sanitario genotoxicidad |
| description |
Cytogenetic biomonitoring techniques allow early detection of exposure to genotoxic agents and the sister chromatid exchange assay (SCE) that was applied aimed to evaluate these effects in peripheral blood lymphocytes of health personnel exposed to antineoplastic drugs in a Hospital Complex of Lima. The exposed group was subdivided according to the proximity to the oncological preparations in: direct, intermediate and low contact, in addition there was a control group. The information was analyzed in the statistical program IBM SPSS 25.0. Statistically significant differences were found in the frequencies of exchanges in the groups of health personnel with direct and intermediate exposure compared to the control group (P<0.05), the comparative analysis between personnel with leave and the control group did not show significant differences. These findings allow evidence of a higher risk of genotoxicity for health personnel exposed to antineoplastic drugs. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-03-29 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/22521 10.15381/ci.v24i2.22521 |
| url |
https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/22521 |
| identifier_str_mv |
10.15381/ci.v24i2.22521 |
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spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/22521/18038 |
| dc.rights.none.fl_str_mv |
Derechos de autor 2022 Fredy Cruz-Bueza, Luis Inostroza-Ruiz, Javier Córdova-Ramos http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Derechos de autor 2022 Fredy Cruz-Bueza, Luis Inostroza-Ruiz, Javier Córdova-Ramos http://creativecommons.org/licenses/by/4.0 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquímica |
| publisher.none.fl_str_mv |
Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquímica |
| dc.source.none.fl_str_mv |
Ciencia e Investigación; Vol. 24 Núm. 2 (2021); 15-20 Ciencia e Investigación; Vol. 24 No. 2 (2021); 15-20 1609-9044 1561-0861 reponame:Revistas - Universidad Nacional Mayor de San Marcos instname:Universidad Nacional Mayor de San Marcos instacron:UNMSM |
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Universidad Nacional Mayor de San Marcos |
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UNMSM |
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UNMSM |
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Revistas - Universidad Nacional Mayor de San Marcos |
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Revistas - Universidad Nacional Mayor de San Marcos |
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Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
