An update on diagnosis of coeliac disease

• Autor: Real Delor, Raúl Emilio
• Formato: artículo
• Fecha de Publicación: 2016
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/12657
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/12657
• Nivel de acceso: acceso abierto
• Materia: Celiac Disease; IgA Tissue Transglutaminase Antibody; Upper Gastrointestinal Endoscopy; Major Histocompatibility Antigen; Gluten.; Enfermedad Celiaca; Anticuerpo IgA Antitransglutaminasa Tisular; Endoscopia Digestiva Alta; Antígeno Mayor de Histocompatibilidad

Celiac disease (CD) is a multisystem autoimmune condition induced by gluten in genetically susceptible individuals. The classical clinical presentation is the chronic diarrhea syndrome although there are atypical and silent forms, which may lead to diagnostic problems. Diagnosis is based on the detection of various autoantibodies, especially against tissue transglutaminase IgA, although the gold standard is the pathological examination of duodenal biopsies obtained by upper endoscopy. The absence of the HLA gene is a test used to rule CD. The response to gluten-free diet confirms this condition, which if not promptly diagnosed and properly treated can lead to serious complications.