Antimicrobial activity of secondary metabolites of Aspergillus fumigatus sensu stricto on clinical strains of Staphylococcus aureus and Streptococcus pneumoniae

• Autores: Sanchez-Perez, Jorge A., Béjar Castillo, Vilma, Villanueva Cotrina, Freddy, Guevara-Granados, José M.
• Formato: artículo
• Fecha de Publicación: 2020
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/16170
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/16170
• Nivel de acceso: acceso abierto
• Materia: Antibacterianos; Pruebas de Sensibilidad Microbiana; Aspergillus fumigatus; Alcaloides; Staphylococcus aureus; Streptococcus pneumoniae; Antibacterial agents; Microbial Sensitivity Tests; Alkaloids

Introduction. The antibiotic resistance of Gram positive bacteria is a serious public health problem where some palliative measures can be found in the antimicrobial principles of filamentous fungi. Objective. To evaluate the antimicrobial activity of secondary metabolites of a clinical isolation of Aspergillus fumigatus on clinical strains of Staphylococcus aureus and Streptococcus pneumoniae. Methods. The liquid fermentation of A. fumigatus was carried out in a liquid broth sulfate, potato and dextrose; using ethyl acetate for the extraction of secondary metabolites. The antimicrobial activity considered as a halo greater than 6 mm was evaluated using the diffusion disk methodology. Results. A mean of 24,02 ± 2,51 mm and 23,62 ± 4,68 mm was obtained on sensitive and resistant Staphylococcus aureus, respectively. For Streptococcus pneumoniae sensitive and non-susceptible, the means were 25,82 ± 4,05 mm and 26,5 ± 5,39 mm, respectively. Conclusions. The crude extract of A. fumigatus has secondary metabolites of alkaloid nature and unsaturated sterols with antimicrobial activity.