Clinical manifestations and maternal-perinatal results of covid-19 associated with pregnancy: a systematic review

• Autores: Chilipio-Chiclla, Marco Antonio, Campos-Correa, Karen Elizabeth
• Formato: artículo
• Fecha de Publicación: 2020
• Institución: Sociedad Materno Fetal
• Repositorio: Revista Internacional de Salud Materno Fetal
• Lenguaje: español
• OAI Identifier: oai:ojs2.ojs.revistamaternofetal.com:article/181
• Enlace del recurso: http://ojs.revistamaternofetal.com/index.php/RISMF/article/view/181
• Nivel de acceso: acceso abierto
• Materia: Evaluación de síntomas; Complicaciones del embarazo; Infecciones por Coronavirus; Resultado del embarazo

Objectives: To evaluate the clinical manifestations and maternal-perinatal results of COVID-19 infection associated with pregnancy. Material and methods: Eight electronic databases (Science Direct, Pubmed, Lilacs, Scielo, Redalyc, LitCovid, EBSCO and Scopus) were reviewed. Full text primary studies in Spanish and English were considered; published between January 1 and May 15, 2020; and performed in pregnant women with a confirmed diagnosis of COVID-19 (reverse transcription polymerase chain reaction [RT-PCR]. Results: 15 studies were included that reported 224 cases of pregnancy-associated COVID-19 infection, mainly in third trimester pregnant women (13/15). Cough and fever were the main clinical manifestations reported in all the investigations. Less than a third of studies show abdominal pain as an obstetric manifestation that motivates attention seeking. The epidemiological history of exposure and the alterations in auxiliary laboratory tests (lymphopenia and high CRP, mainly) are reported regularly. COVID-19 disease associated with pregnancy occurs mainly mildly; Likewise, mortality and ICU admission are maternal outcomes exclusively associated with the few severe presentations. Cesarean section is the most used route of completion, with COVID-19 pneumonia being the cited indication in a few cases. Low birth weight and NICU admission are perinatal outcomes described in 9 of 15 studies, with little perinatal mortality. Only in three studies is vertical transmission reported. Conclusion: COVID-19 disease associated with pregnancy is mainly reported in third trimester pregnant women, with fever and cough present at admission, being mostly mild cases. Likewise, it generates few maternal-perinatal complications; however, in severe cases, morbidity and mortality becomes more frequent.