High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake Titicaca

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We have analized the combination of variants at 4 sites of the gene MBL (mannose binding lectin) which is part of the immune system, in 19 normal individuals from the islands of Anapia-Suana in the Lake Titicaca. OnIy 3 combinations (haplotypes) were registered: LYPB, HYPA and LYPA; the proportion o...

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Detalles Bibliográficos
Autores: Sandoval S., José, Madsen, Hans O., Garred, Peter, Fujita, Ricardo
Formato: artículo
Fecha de Publicación:2022
Institución:Universidad de San Martín de Porres
Repositorio:Horizonte médico
Lenguaje:español
OAI Identifier:oai:horizontemedico.usmp.edu.pe:article/2010
Enlace del recurso:https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/2010
Nivel de acceso:acceso abierto
Materia:Gene MBL
Haplotypes LYPB
HYPA
LYPA
Sistema inmune MBL
Haplotipos LYPB
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spelling High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake TiticacaAlta frecuencia de un haplotipo susceptible del gen Mannose Binding Lectin, en las islas AnapiaSuana del lago TiticacaSandoval S., JoséMadsen, Hans O.Garred, PeterFujita, RicardoGene MBLHaplotypes LYPBHYPALYPASistema inmune MBLHaplotipos LYPBHYPALYPAWe have analized the combination of variants at 4 sites of the gene MBL (mannose binding lectin) which is part of the immune system, in 19 normal individuals from the islands of Anapia-Suana in the Lake Titicaca. OnIy 3 combinations (haplotypes) were registered: LYPB, HYPA and LYPA; the proportion of the pressumed defective haplotype LYPB is 0.58 being the highest ever recorded. This haplotype is rare among European, Asian and African populations. It predisposes to infectious diseases as tuberculosis and AIDS as well as autoimmune diseases like reumatoid arthritis and lupus erithematosumo This finding lead our future efforts to elucidate the reason of this high frequency of LYPB and to determine its proportion in other islands of the Titicaca Lake.Se determinaron las combinaciones de variantes genéticas en 4 sitios del gen de la proteína asociada al sistema inmune MBL (mannose binding lectin), en 19 pobladores de las islas de AnapiaSuana del Lago Titicaca. Se encuentran solamente 3 combinaciones (haplotipos): LYFB, HYPA Y LYPA y se observa alta frecuencia (0.58) del haplotipo defectuoso LYPB en las mencionadas islas sobrepasando a otras frecuencias previamente reportadas en el mundo. Este haplotipo es poco frecuente en poblaciones europeas, asiáticas y africanas. La deficiencia sérica de LYPB predispone a infecciones como tuberculosis, VIH-1 y a enfermedades autoinmunes como artritis reumatoide y lupus eritematoso entre otras. Con estos antecedentes nuestros futuros esfuerzos se dirigirán a investigar la razón de la alta frecuencia de LYPB en estas islas y determinar la de las otras islas aledañas.Universidad de San Martín de Porres. Facultad de Medicina Humana2022-08-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/201010.24265/horizmed.2002.v2n1.01Horizonte Médico (Lima); Vol. 2 No. 1/2 (2002)Horizonte Médico (Lima); Vol. 2 Núm. 1/2 (2002)Horizonte Médico (Lima); v. 2 n. 1/2 (2002)2227-35301727-558Xreponame:Horizonte médicoinstname:Universidad de San Martín de Porresinstacron:USMPspahttps://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/2010/1232Derechos de autor 2022 Horizonte Médico (Lima)https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:horizontemedico.usmp.edu.pe:article/20102022-08-18T03:56:13Z
dc.title.none.fl_str_mv High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake Titicaca
Alta frecuencia de un haplotipo susceptible del gen Mannose Binding Lectin, en las islas AnapiaSuana del lago Titicaca
title High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake Titicaca
spellingShingle High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake Titicaca
Sandoval S., José
Gene MBL
Haplotypes LYPB
HYPA
LYPA
Sistema inmune MBL
Haplotipos LYPB
HYPA
LYPA
title_short High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake Titicaca
title_full High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake Titicaca
title_fullStr High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake Titicaca
title_full_unstemmed High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake Titicaca
title_sort High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake Titicaca
dc.creator.none.fl_str_mv Sandoval S., José
Madsen, Hans O.
Garred, Peter
Fujita, Ricardo
author Sandoval S., José
author_facet Sandoval S., José
Madsen, Hans O.
Garred, Peter
Fujita, Ricardo
author_role author
author2 Madsen, Hans O.
Garred, Peter
Fujita, Ricardo
author2_role author
author
author
dc.subject.none.fl_str_mv Gene MBL
Haplotypes LYPB
HYPA
LYPA
Sistema inmune MBL
Haplotipos LYPB
HYPA
LYPA
topic Gene MBL
Haplotypes LYPB
HYPA
LYPA
Sistema inmune MBL
Haplotipos LYPB
HYPA
LYPA
description We have analized the combination of variants at 4 sites of the gene MBL (mannose binding lectin) which is part of the immune system, in 19 normal individuals from the islands of Anapia-Suana in the Lake Titicaca. OnIy 3 combinations (haplotypes) were registered: LYPB, HYPA and LYPA; the proportion of the pressumed defective haplotype LYPB is 0.58 being the highest ever recorded. This haplotype is rare among European, Asian and African populations. It predisposes to infectious diseases as tuberculosis and AIDS as well as autoimmune diseases like reumatoid arthritis and lupus erithematosumo This finding lead our future efforts to elucidate the reason of this high frequency of LYPB and to determine its proportion in other islands of the Titicaca Lake.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-18
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/2010
10.24265/horizmed.2002.v2n1.01
url https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/2010
identifier_str_mv 10.24265/horizmed.2002.v2n1.01
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/2010/1232
dc.rights.none.fl_str_mv Derechos de autor 2022 Horizonte Médico (Lima)
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2022 Horizonte Médico (Lima)
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad de San Martín de Porres. Facultad de Medicina Humana
publisher.none.fl_str_mv Universidad de San Martín de Porres. Facultad de Medicina Humana
dc.source.none.fl_str_mv Horizonte Médico (Lima); Vol. 2 No. 1/2 (2002)
Horizonte Médico (Lima); Vol. 2 Núm. 1/2 (2002)
Horizonte Médico (Lima); v. 2 n. 1/2 (2002)
2227-3530
1727-558X
reponame:Horizonte médico
instname:Universidad de San Martín de Porres
instacron:USMP
instname_str Universidad de San Martín de Porres
instacron_str USMP
institution USMP
reponame_str Horizonte médico
collection Horizonte médico
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1852964721179754496
score 13.110079
High frequency of a susceptible haplotype of the Mannose Binding Lectin gene, in the AnapiaSuana islands of Lake Titicaca
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