Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals

• Autores: Pareja Cruz, Arturo, de León Delgado, Joel, Navarrete Mejía, Pedro Javier, Luque Espino, Julio César, Gonzáles Moscoso, Jesús Demóstenes
• Formato: artículo
• Fecha de Publicación: 2021
• Institución: Universidad de San Martín de Porres
• Repositorio: Horizonte médico
• Lenguaje: español
• OAI Identifier: oai:horizontemedico.usmp.edu.pe:article/1543
• Enlace del recurso: https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1543
• Nivel de acceso: acceso abierto
• Materia: Anticuerpos neutralizantes; COVID-19; Inmunogenicidad; Vacunación; Personal de salud; Neutralizing antibodies; Coronavirus infections; Immunogenicity; Vaccination; Health personnel

Objective: To describe the presence and the concentration of neutralizing antibodies at serum of healthcare professionals inoculated with the Sinopharm anti-SARS-CoV2 vaccine. Materials and methods: Descriptive and transversal research. A total of 117 healthcare professionals inoculated with two doses of the Sinopharm vaccine having quantitative data of neutralizing antibodies at serum (detected by eCLIA) were included. Age, sex, neutralizing antibodies concentration and previous diagnostic of COVID-19 diseases were the variables. Results: A significant increase on neutralizing antibodies concentration were detected on pre- COVID-19 vaccinated persons regarding those vaccinated without previous diagnostic of the viral infection (p < 0,001). Conclusions: the study evidence that Sinopharm vaccine boost immunity against the new coronavirus on previously infected persons and suggest that a third dose of the vaccine could be relevant to boost the immune response.