Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report

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Introduction: Pulmonary infections by nontuberculous mycobacteria (NTM) represent a serious clinical problem because they produce progressive, severe and difficult to treat pictures. Case report: We present two patients without immunosuppressive comorbidity with pulmonary infection by Mycobacterium...

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Autores: Ramirez, Percy C., Campos-Huaman, Alex, Segama-Gonzales, Jossmert, Montalvo-Otivo , Raúl
Formato: artículo
Fecha de Publicación:2025
Institución:Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
Repositorio:Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
Lenguaje:español
OAI Identifier:oai:cmhnaaa_ojs_cmhnaaa.cmhnaaa.org.pe:article/2357
Enlace del recurso:https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/2357
Nivel de acceso:acceso abierto
Materia:Mycobacterium
Micobacterias no Tuberculosas
Mycobacterium abscessus
Mycobacterium kansasii
Amicacina
Nontuberculous Mycobacteria
Amikacin
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spelling Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report Mycobacterium abscessus y kansasii tratados satisfactoriamente con amikacina inhalada: Reporte de caso Ramirez, Percy C.Campos-Huaman, AlexSegama-Gonzales, Jossmert Montalvo-Otivo , Raúl MycobacteriumMicobacterias no TuberculosasMycobacterium abscessusMycobacterium kansasiiAmicacina MycobacteriumNontuberculous MycobacteriaMycobacterium abscessusMycobacterium kansasiiAmikacinIntroduction: Pulmonary infections by nontuberculous mycobacteria (NTM) represent a serious clinical problem because they produce progressive, severe and difficult to treat pictures. Case report: We present two patients without immunosuppressive comorbidity with pulmonary infection by Mycobacterium abscessus and Mycobacterium kansasii, with clinical and radiographic improvement after receiving inhalation amikacin. The use of this drug added to standard therapy allowed a favorable evolution due to its high concentration in the alveolar tissue in infection by non-tuberculous mycobacteria. Discussion: Initial therapy to treat NTM infections based on a macrolide, ethambutol and rifampicin is often not sufficient. Inhalation amikacin is proposed as rescue therapy due to its potent antimicrobial activity, achieving a high concentration and a longer time in lung tissue with less toxic effects. Conclusion: A favorable clinical response was evidenced with the combined treatment with inhaled amikacin.Introducción: Las infecciones pulmonares por mycobacterias no tuberculosas (MNT) representan un serio problema clínico debido a que producen cuadros progresivos, severos y de difícil tratamiento. Reporte de caso: Se presenta dos pacientes sin comorbilidad inmunosupresora con infección pulmonar por Mycobacterium abscessus y Mycobacterium kansasii, con mejoría clínica y radiográfica después de recibir amikacina inhalatoria. El uso de este medicamento agregado a la terapia estándar permitió una evolución favorable debido a su alta concentración en el tejido alveolar en la infección por mycobacterias no tuberculosas. Discusión: La terapia inicial para tratar las infecciones por MNT a base de un macrólido, etambutol y rifampicina muchas veces no es suficiente. La amikacina inhalatoria se propone como terapia de rescate por su potente actividad antimicrobiana, logrando una alta concentración y un tiempo más prolongado en el tejido pulmonar con menos efectos tóxicos. Conclusión: Se evidenció una respuesta clínica favorable con el tratamiento combinado con amikacina inhalada.Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo2025-02-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/235710.35434/rcmhnaaa.2024.174.2357Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo; Vol. 17 No. 4 (2024): Rev. Cuerpo Med. HNAAA, October - December; e2357Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo; Vol. 17 Núm. 4 (2024): Rev. Cuerpo Med. HNAAA, Octubre - Diciembre; e23572227-47312225-510910.35434/rcmhnaaa.2024.174reponame:Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjoinstname:Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjoinstacron:HNAAAspahttps://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/2357/972Derechos de autor 2025 Percy C. Ramirez, Alex Campos Huaman, Jossmert Segama Gonzales, Raúl Montalvo Otivo https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:cmhnaaa_ojs_cmhnaaa.cmhnaaa.org.pe:article/23572025-05-19T04:52:26Z
dc.title.none.fl_str_mv Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report
Mycobacterium abscessus y kansasii tratados satisfactoriamente con amikacina inhalada: Reporte de caso
title Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report
spellingShingle Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report
Ramirez, Percy C.
Mycobacterium
Micobacterias no Tuberculosas
Mycobacterium abscessus
Mycobacterium kansasii
Amicacina
Mycobacterium
Nontuberculous Mycobacteria
Mycobacterium abscessus
Mycobacterium kansasii
Amikacin
title_short Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report
title_full Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report
title_fullStr Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report
title_full_unstemmed Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report
title_sort Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report
dc.creator.none.fl_str_mv Ramirez, Percy C.
Campos-Huaman, Alex
Segama-Gonzales, Jossmert
Montalvo-Otivo , Raúl
author Ramirez, Percy C.
author_facet Ramirez, Percy C.
Campos-Huaman, Alex
Segama-Gonzales, Jossmert
Montalvo-Otivo , Raúl
author_role author
author2 Campos-Huaman, Alex
Segama-Gonzales, Jossmert
Montalvo-Otivo , Raúl
author2_role author
author
author
dc.subject.none.fl_str_mv Mycobacterium
Micobacterias no Tuberculosas
Mycobacterium abscessus
Mycobacterium kansasii
Amicacina
Mycobacterium
Nontuberculous Mycobacteria
Mycobacterium abscessus
Mycobacterium kansasii
Amikacin
topic Mycobacterium
Micobacterias no Tuberculosas
Mycobacterium abscessus
Mycobacterium kansasii
Amicacina
Mycobacterium
Nontuberculous Mycobacteria
Mycobacterium abscessus
Mycobacterium kansasii
Amikacin
description Introduction: Pulmonary infections by nontuberculous mycobacteria (NTM) represent a serious clinical problem because they produce progressive, severe and difficult to treat pictures. Case report: We present two patients without immunosuppressive comorbidity with pulmonary infection by Mycobacterium abscessus and Mycobacterium kansasii, with clinical and radiographic improvement after receiving inhalation amikacin. The use of this drug added to standard therapy allowed a favorable evolution due to its high concentration in the alveolar tissue in infection by non-tuberculous mycobacteria. Discussion: Initial therapy to treat NTM infections based on a macrolide, ethambutol and rifampicin is often not sufficient. Inhalation amikacin is proposed as rescue therapy due to its potent antimicrobial activity, achieving a high concentration and a longer time in lung tissue with less toxic effects. Conclusion: A favorable clinical response was evidenced with the combined treatment with inhaled amikacin.
publishDate 2025
dc.date.none.fl_str_mv 2025-02-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/2357
10.35434/rcmhnaaa.2024.174.2357
url https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/2357
identifier_str_mv 10.35434/rcmhnaaa.2024.174.2357
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/2357/972
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo
publisher.none.fl_str_mv Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo
dc.source.none.fl_str_mv Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo; Vol. 17 No. 4 (2024): Rev. Cuerpo Med. HNAAA, October - December; e2357
Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo; Vol. 17 Núm. 4 (2024): Rev. Cuerpo Med. HNAAA, Octubre - Diciembre; e2357
2227-4731
2225-5109
10.35434/rcmhnaaa.2024.174
reponame:Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
instname:Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
instacron:HNAAA
instname_str Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
instacron_str HNAAA
institution HNAAA
reponame_str Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
collection Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
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repository.mail.fl_str_mv
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Mycobacterium abscessus and kansasii successfully treated with inhaled amikacin: Case report
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