Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report

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Introduction: Tuberculosis is one of the 10 leading causes of death worldwide. In 2020, it caused 1.5 million deaths. It is estimated that it reached 10.0 million new cases during the same year. Case of report: 93-year-old male, history of pulmonary TB 15 years ago and current TB contact. He present...

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Autores: Farfán-Chávez, Luis Gabriel, Pérez-Acuña Medina, Katherine Alexandra
Formato: artículo
Fecha de Publicación:2023
Institución:Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
Repositorio:Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
Lenguaje:español
OAI Identifier:oai:cmhnaaa_ojs_cmhnaaa.cmhnaaa.org.pe:article/1645
Enlace del recurso:https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1645
Nivel de acceso:acceso abierto
Materia:tuberculosis pleural
derrame pleural
efectos adversos
antituberculosos
pleural tuberculosis
pleural effusion
adverse effects
antitubercular drugs
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spelling Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case reportEsquema antituberculoso modificado por hepatotoxicidad causada por Pirazinamida: reporte de casoFarfán-Chávez, Luis GabrielPérez-Acuña Medina, Katherine Alexandratuberculosis pleuralderrame pleuralefectos adversosantituberculosospleural tuberculosispleural effusionadverse effectsantitubercular drugsIntroduction: Tuberculosis is one of the 10 leading causes of death worldwide. In 2020, it caused 1.5 million deaths. It is estimated that it reached 10.0 million new cases during the same year. Case of report: 93-year-old male, history of pulmonary TB 15 years ago and current TB contact. He presented dyspnea and pleuritic pain for 4 months. Thoracocentesis concludes exudate, pleural biopsy compatible with non-caseating granulomatous pleurisy. Receive antituberculosis regimen, developing hepatic RAFA. Pharmacological challenge is performed to design a new treatment scheme. Patient manages to recover. It is concluded that the management of tuberculosis should be individualized.Introducción: La tuberculosis es una de las 10 principales causas de muerte a nivel mundial. En 2020, causó 1,5 millones muertes. Se estima que llegó a 10,0 millones de nuevos casos durante el mismo año. Reporte de caso: varón de 93 años, antecedente de TBC pulmonar hace 15 años y contacto TBC actual. Presenta disnea y dolor pleurítico por 4 meses. Toracocentesis concluye exudado, biopsia pleural compatible con pleuritis granulomatosa no caseificante. Recibe esquema antituberculoso, desarrollando RAFA hepática. Se realiza reto farmacológico para diseñar un nuevo esquema de tratamiento. Paciente logra recuperarse. Se concluye que el manejo de tuberculosis debe individualizarse según paciente.Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo2023-06-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/164510.35434/rcmhnaaa.2023.161.1645Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo; Vol. 16 No. 1 (2023): Rev. Cuerpo Med. HNAAA, January - March; e1645Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo; Vol. 16 Núm. 1 (2023): Rev. Cuerpo Med. HNAAA, Enero - Marzo; e16452227-47312225-510910.35434/rcmhnaaa.2023.161reponame:Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjoinstname:Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjoinstacron:HNAAAspahttps://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1645/761Derechos de autor 2023 Luis Gabriel Farfán-Chávez, Katherine Alexandra Pérez-Acuña Medinahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:cmhnaaa_ojs_cmhnaaa.cmhnaaa.org.pe:article/16452025-03-11T13:38:08Z
dc.title.none.fl_str_mv Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report
Esquema antituberculoso modificado por hepatotoxicidad causada por Pirazinamida: reporte de caso
title Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report
spellingShingle Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report
Farfán-Chávez, Luis Gabriel
tuberculosis pleural
derrame pleural
efectos adversos
antituberculosos
pleural tuberculosis
pleural effusion
adverse effects
antitubercular drugs
title_short Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report
title_full Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report
title_fullStr Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report
title_full_unstemmed Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report
title_sort Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report
dc.creator.none.fl_str_mv Farfán-Chávez, Luis Gabriel
Pérez-Acuña Medina, Katherine Alexandra
author Farfán-Chávez, Luis Gabriel
author_facet Farfán-Chávez, Luis Gabriel
Pérez-Acuña Medina, Katherine Alexandra
author_role author
author2 Pérez-Acuña Medina, Katherine Alexandra
author2_role author
dc.subject.none.fl_str_mv tuberculosis pleural
derrame pleural
efectos adversos
antituberculosos
pleural tuberculosis
pleural effusion
adverse effects
antitubercular drugs
topic tuberculosis pleural
derrame pleural
efectos adversos
antituberculosos
pleural tuberculosis
pleural effusion
adverse effects
antitubercular drugs
description Introduction: Tuberculosis is one of the 10 leading causes of death worldwide. In 2020, it caused 1.5 million deaths. It is estimated that it reached 10.0 million new cases during the same year. Case of report: 93-year-old male, history of pulmonary TB 15 years ago and current TB contact. He presented dyspnea and pleuritic pain for 4 months. Thoracocentesis concludes exudate, pleural biopsy compatible with non-caseating granulomatous pleurisy. Receive antituberculosis regimen, developing hepatic RAFA. Pharmacological challenge is performed to design a new treatment scheme. Patient manages to recover. It is concluded that the management of tuberculosis should be individualized.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1645
10.35434/rcmhnaaa.2023.161.1645
url https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1645
identifier_str_mv 10.35434/rcmhnaaa.2023.161.1645
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1645/761
dc.rights.none.fl_str_mv Derechos de autor 2023 Luis Gabriel Farfán-Chávez, Katherine Alexandra Pérez-Acuña Medina
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2023 Luis Gabriel Farfán-Chávez, Katherine Alexandra Pérez-Acuña Medina
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo
publisher.none.fl_str_mv Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo
dc.source.none.fl_str_mv Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo; Vol. 16 No. 1 (2023): Rev. Cuerpo Med. HNAAA, January - March; e1645
Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo; Vol. 16 Núm. 1 (2023): Rev. Cuerpo Med. HNAAA, Enero - Marzo; e1645
2227-4731
2225-5109
10.35434/rcmhnaaa.2023.161
reponame:Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
instname:Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
instacron:HNAAA
instname_str Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
instacron_str HNAAA
institution HNAAA
reponame_str Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
collection Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Modified antituberculosis regimen due to hepatotoxicity caused by Pyrazinamide: Case report
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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

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