Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2

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A full version of this paper is published Veterinary Immunology & Immunopathology (2005) Jun 15;106(1-2):77-86
Detalles Bibliográficos
Autores: Timoteo, Olga, Espinoza, José
Formato: artículo
Fecha de Publicación:2005
Institución:Instituto Peruano de Energía Nuclear
Repositorio:IPEN-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.ipen.gob.pe:20.500.13054/444
Enlace del recurso:https://hdl.handle.net/20.500.13054/444
Nivel de acceso:acceso abierto
Materia:Alpacas
Fasciola hepatica
Camélidos sudamericanos
Enfermedades infecciosas
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spelling Timoteo, OlgaEspinoza, JoséEspinoza, JoséTimoteo, Olga2015-08-14T20:07:56Z2015-08-14T20:07:56Z2005-08Timoteo O, Espinoza J. Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2. Informe Científico Tecnológico. Volumen 4 (2004) p. 172-178.1684-1662https://hdl.handle.net/20.500.13054/444A full version of this paper is published Veterinary Immunology & Immunopathology (2005) Jun 15;106(1-2):77-86A characterization of the humoral immune response of alpacas to Fasciola hepatica Fas1 and Fas2 antigens cysteine proteinases was performed over the course of 6 months of experimental infection. Six adult alpacas aged 1 to 2 years old received a single dose of 200 F. hepatica metacercariae, 2 non–infected alpacas were kept as control group. Peripheral eosinophilia in infected animals was greatly enhanced 6 weeks PI and later. A single peak of alanine aminotransferase (SGPT) was observed 4 week PI and aspartate aminotransferase (SGOT) elevated 3 weeks PI and later. All infected animals shed eggs 8 week PI and the number of flukes recovered at necropsy averaged 41 ± 4. Circulating IgG Abs against Fas1 and Fas2 were measured by ELISA. Fas2-ELISA detected the infection 10 days PI reaching to highest titer on 7-8 week PI and kept elevated until the end of infection. Fas1-ELISA detected the infection 2 weeks PI and followed the same pattern as Fas2-ELISA. Anti Fas2 IgG Abs were in higher titers and showed stronger avidity than anti Fas1 IgG Abs. In the present study we have established a F. hepatica experimental infection of alpacas that might be employed as a model to search for genes involved in the susceptibility to helminth infection in alpacas.This work was partially funded by a grant B/2856-1 from the International Foundation for Science and INCAGRO Contract 007-2003 to JRE.application/pdfengLima (Perú)PEinfo:eu-repo/semantics/openAccessInstituto Peruano de Energía NuclearRepositorio Institucional del Instituto Peruano de Energía Nuclearreponame:IPEN-Institucionalinstname:Instituto Peruano de Energía Nuclearinstacron:IPENAlpacasFasciola hepaticaCamélidos sudamericanosEnfermedades infecciosasImmune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2info:eu-repo/semantics/articleORIGINAL_172-178_ Alpacas 2.1.pdf_172-178_ Alpacas 2.1.pdfapplication/pdf144149https://repositorio.ipen.gob.pe/bitstream/20.500.13054/444/1/_172-178_%20Alpacas%202.1.pdff93d79a7b468861c55d07c10f7bbaac5MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-8103https://repositorio.ipen.gob.pe/bitstream/20.500.13054/444/2/license.txt7ecf7b0639239de61a3a1ede9c397fecMD52TEXT_172-178_ Alpacas 2.1.pdf.txt_172-178_ Alpacas 2.1.pdf.txtExtracted texttext/plain22306https://repositorio.ipen.gob.pe/bitstream/20.500.13054/444/3/_172-178_%20Alpacas%202.1.pdf.txtd1a594d13fd0b2bbc177571a66adb03aMD53THUMBNAIL_172-178_ Alpacas 2.1.pdf.jpg_172-178_ Alpacas 2.1.pdf.jpgGenerated Thumbnailimage/jpeg21508https://repositorio.ipen.gob.pe/bitstream/20.500.13054/444/4/_172-178_%20Alpacas%202.1.pdf.jpg9b3a9c403b8c490cec045e10e117221dMD5420.500.13054/444oai:repositorio.ipen.gob.pe:20.500.13054/4442022-02-07 18:06:27.507Repositorio Institucional del Instituto Peruano de Energía Nuclearrepositorio@ipen.gob.peU2UgRGlzdHJpYnV5ZSBiYWpvIHVuYSBMaWNlbmNpYSBDcmVhdGl2ZSBDb21tb25zIEF0cmlidWNpw7NuLU5vQ29tZXJjaWFsLVNpbkRlcml2YXIgNC4wIEludGVybmFjaW9uYWwuCg==
dc.title.es_PE.fl_str_mv Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2
title Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2
spellingShingle Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2
Timoteo, Olga
Alpacas
Fasciola hepatica
Camélidos sudamericanos
Enfermedades infecciosas
title_short Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2
title_full Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2
title_fullStr Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2
title_full_unstemmed Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2
title_sort Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2
dc.creator.none.fl_str_mv Espinoza, José
Timoteo, Olga
author Timoteo, Olga
author_facet Timoteo, Olga
Espinoza, José
author_role author
author2 Espinoza, José
author2_role author
dc.contributor.author.fl_str_mv Timoteo, Olga
Espinoza, José
dc.subject.es_PE.fl_str_mv Alpacas
Fasciola hepatica
Camélidos sudamericanos
Enfermedades infecciosas
topic Alpacas
Fasciola hepatica
Camélidos sudamericanos
Enfermedades infecciosas
description A full version of this paper is published Veterinary Immunology & Immunopathology (2005) Jun 15;106(1-2):77-86
publishDate 2005
dc.date.accessioned.none.fl_str_mv 2015-08-14T20:07:56Z
dc.date.available.none.fl_str_mv 2015-08-14T20:07:56Z
dc.date.issued.fl_str_mv 2005-08
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.es_PE.fl_str_mv Timoteo O, Espinoza J. Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2. Informe Científico Tecnológico. Volumen 4 (2004) p. 172-178.
dc.identifier.issn.none.fl_str_mv 1684-1662
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.13054/444
identifier_str_mv Timoteo O, Espinoza J. Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2. Informe Científico Tecnológico. Volumen 4 (2004) p. 172-178.
1684-1662
url https://hdl.handle.net/20.500.13054/444
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv Lima (Perú)
dc.publisher.country.es_PE.fl_str_mv PE
dc.source.es_PE.fl_str_mv Instituto Peruano de Energía Nuclear
Repositorio Institucional del Instituto Peruano de Energía Nuclear
dc.source.none.fl_str_mv reponame:IPEN-Institucional
instname:Instituto Peruano de Energía Nuclear
instacron:IPEN
instname_str Instituto Peruano de Energía Nuclear
instacron_str IPEN
institution IPEN
reponame_str IPEN-Institucional
collection IPEN-Institucional
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Immune response in alpacas against Fasciola hepatica cysteine proteinases Fas1 and Fas2
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