Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon

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This research was supported by a grant fromSENACYT FID 16-201 to J. P. C. and A. V., Secretar ́ıa Nacional deCiencia y Tecnolog ́ıa from Panama; by the grant for neglected dis-eases studies in Panama 1.11.1.3.703.01.55.120 from the Ministry ofEconomy and Finance of Panama to J. P. C. and A. V.; and...

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Autores: Pérez, Jocelyn G., Carrera, Jean-Paul, Serrano, Emmanuel, Pittí, Yaneth, Maguiña, Jorge L., Mentaberre, Gregorio, Lescano, Andrés G., Valderrama, Anayansi, Mayor, Pedro
Formato: artículo
Fecha de Publicación:2019
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/2758
Enlace del recurso:https://hdl.handle.net/20.500.12390/2758
https://doi.org/10.4269/ajtmh.18-0850
Nivel de acceso:acceso abierto
Materia:Virology
Infectious Diseases
Parasitology
http://purl.org/pe-repo/ocde/ford#3.03.09
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network_name_str CONCYTEC-Institucional
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dc.title.none.fl_str_mv Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon
title Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon
spellingShingle Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon
Pérez, Jocelyn G.
Virology
Infectious Diseases
Parasitology
http://purl.org/pe-repo/ocde/ford#3.03.09
title_short Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon
title_full Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon
title_fullStr Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon
title_full_unstemmed Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon
title_sort Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon
author Pérez, Jocelyn G.
author_facet Pérez, Jocelyn G.
Carrera, Jean-Paul
Serrano, Emmanuel
Pittí, Yaneth
Maguiña, Jorge L.
Mentaberre, Gregorio
Lescano, Andrés G.
Valderrama, Anayansi
Mayor, Pedro
author_role author
author2 Carrera, Jean-Paul
Serrano, Emmanuel
Pittí, Yaneth
Maguiña, Jorge L.
Mentaberre, Gregorio
Lescano, Andrés G.
Valderrama, Anayansi
Mayor, Pedro
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pérez, Jocelyn G.
Carrera, Jean-Paul
Serrano, Emmanuel
Pittí, Yaneth
Maguiña, Jorge L.
Mentaberre, Gregorio
Lescano, Andrés G.
Valderrama, Anayansi
Mayor, Pedro
dc.subject.none.fl_str_mv Virology
topic Virology
Infectious Diseases
Parasitology
http://purl.org/pe-repo/ocde/ford#3.03.09
dc.subject.es_PE.fl_str_mv Infectious Diseases
Parasitology
dc.subject.ocde.none.fl_str_mv http://purl.org/pe-repo/ocde/ford#3.03.09
description This research was supported by a grant fromSENACYT FID 16-201 to J. P. C. and A. V., Secretar ́ıa Nacional deCiencia y Tecnolog ́ıa from Panama; by the grant for neglected dis-eases studies in Panama 1.11.1.3.703.01.55.120 from the Ministry ofEconomy and Finance of Panama to J. P. C. and A. V.; and byERANet17/HLH-0271. Scott Weaver also supported this studythrough the World Reference Center for Emerging Viruses and Arbo-viruses, NIH grant R24AI120942. Dr. Lescano is sponsored by thetraining grant D43 TW007393 awarded by the Fogarty InternationalCenter of the US National Institutes of Health. J. L. M. is a doctoralcandidate studying an Epidemiological Research Doctorate at Uni-versidad Peruana Cayetano Heredia under FONDECYT/CIENCIAC-TIVA scholarship EF033-235-2015 and also supported by traininggrant D43 TW007393. A. V. is a member of the Sistema Nacional deInvestigaci ́on de Panam ́a (SNI),SENACYT.E.S. was supportedby theSpanish Ministerio de Ciencia Innovaci ́on y Universidades (MICINN)through a Ramon y Cajal agreement (RYC-2016-21120).
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/2758
dc.identifier.doi.none.fl_str_mv https://doi.org/10.4269/ajtmh.18-0850
dc.identifier.scopus.none.fl_str_mv 2-s2.0-85076062339
url https://hdl.handle.net/20.500.12390/2758
https://doi.org/10.4269/ajtmh.18-0850
identifier_str_mv 2-s2.0-85076062339
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv American Journal of Tropical Medicine and Hygiene
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
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spelling Publicationrp07381600rp07383600rp01125600rp07384600rp06199600rp01126600rp00723600rp07382600rp07385600Pérez, Jocelyn G.Carrera, Jean-PaulSerrano, EmmanuelPittí, YanethMaguiña, Jorge L.Mentaberre, GregorioLescano, Andrés G.Valderrama, AnayansiMayor, Pedro2024-05-30T23:13:38Z2024-05-30T23:13:38Z2019https://hdl.handle.net/20.500.12390/2758https://doi.org/10.4269/ajtmh.18-08502-s2.0-85076062339This research was supported by a grant fromSENACYT FID 16-201 to J. P. C. and A. V., Secretar ́ıa Nacional deCiencia y Tecnolog ́ıa from Panama; by the grant for neglected dis-eases studies in Panama 1.11.1.3.703.01.55.120 from the Ministry ofEconomy and Finance of Panama to J. P. C. and A. V.; and byERANet17/HLH-0271. Scott Weaver also supported this studythrough the World Reference Center for Emerging Viruses and Arbo-viruses, NIH grant R24AI120942. Dr. Lescano is sponsored by thetraining grant D43 TW007393 awarded by the Fogarty InternationalCenter of the US National Institutes of Health. J. L. M. is a doctoralcandidate studying an Epidemiological Research Doctorate at Uni-versidad Peruana Cayetano Heredia under FONDECYT/CIENCIAC-TIVA scholarship EF033-235-2015 and also supported by traininggrant D43 TW007393. A. V. is a member of the Sistema Nacional deInvestigaci ́on de Panam ́a (SNI),SENACYT.E.S. was supportedby theSpanish Ministerio de Ciencia Innovaci ́on y Universidades (MICINN)through a Ramon y Cajal agreement (RYC-2016-21120).Alphaviruses (Togaviridae, Alphavirus) are arthropod-borne single-stranded RNA pathogens that cause febrile and neurologic disease in much of Latin America. However, many features of Alphavirus epidemiology remain unknown. In 2011, we undertook a cross-sectional study in Nueva Esperanza, an indigenous community in the Peruvian Amazon. Here, we present the first serologic evidence of Mayaro (MAYV), Venezuelan equine encephalitis (VEE) complex alphavirus, Una (UNAV), and Madariaga (MADV) viruses reported in humans (24%, 16%, 13%, and 1.5%, respectively) fromanAmazonian indigenous community in Peru. Hunting activity and cohabiting with hunters were the main risk factors for Mayaro seroconversion, butonly huntingwas associated with UNAVseropositivity. Ourresults suggest that alphavirus infection in this region is common, but we highlight the high UNAV seroprevalence found and corroborate the low MADV prevalence reportedinthis region. Furthermore, MAYV-neutralizing antibodies were also detected instored samples from wild animals (18%) hunted by Nueva Esperanza inhabitants and another mestizo community located close to Iquitos. Further serological surveys of VEE complex alphaviruses, UNAV, and MADV in wild animals and assessing the ability of the MAYV seropositive species to transmit the virus will be relevant. Copyright © 2019 by The American Society of Tropical Medicine and Hygiene.Fondo Nacional de Desarrollo Científico y Tecnológico - FondecytengAmerican Society of Tropical Medicine and HygieneAmerican Journal of Tropical Medicine and Hygieneinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/VirologyInfectious Diseases-1Parasitology-1http://purl.org/pe-repo/ocde/ford#3.03.09-1Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazoninfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#ORIGINALtpmd180850.pdftpmd180850.pdfapplication/pdf382351https://repositorio.concytec.gob.pe/bitstreams/9a6e3862-a856-43e7-bceb-69687f82b9f8/downloadd46dd6a64f0d2a6be0c7452873f2cba7MD51TEXTtpmd180850.pdf.txttpmd180850.pdf.txtExtracted texttext/plain34503https://repositorio.concytec.gob.pe/bitstreams/fb1fe555-e9ee-4061-bb56-828e67f01976/downloadb3e0d894ade9c951e8e29b1ae1117658MD52THUMBNAILtpmd180850.pdf.jpgtpmd180850.pdf.jpgGenerated Thumbnailimage/jpeg6455https://repositorio.concytec.gob.pe/bitstreams/88920d5f-e837-4e04-8096-6694ad120f1d/downloade8e59f585c27ea041ebe8221614733d2MD5320.500.12390/2758oai:repositorio.concytec.gob.pe:20.500.12390/27582025-01-16 22:00:15.473https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessopen accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="0638bc45-0741-44b6-a624-3cf50878485d"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon</Title> <PublishedIn> <Publication> <Title>American Journal of Tropical Medicine and Hygiene</Title> </Publication> </PublishedIn> <PublicationDate>2019</PublicationDate> <DOI>https://doi.org/10.4269/ajtmh.18-0850</DOI> <SCP-Number>2-s2.0-85076062339</SCP-Number> <Authors> <Author> <DisplayName>Pérez, Jocelyn G.</DisplayName> <Person id="rp07381" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Carrera, Jean-Paul</DisplayName> <Person id="rp07383" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Serrano, Emmanuel</DisplayName> <Person id="rp01125" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Pittí, Yaneth</DisplayName> <Person id="rp07384" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Maguiña, Jorge L.</DisplayName> <Person id="rp06199" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Mentaberre, Gregorio</DisplayName> <Person id="rp01126" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Lescano, Andrés G.</DisplayName> <Person id="rp00723" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Valderrama, Anayansi</DisplayName> <Person id="rp07382" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Mayor, Pedro</DisplayName> <Person id="rp07385" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>American Society of Tropical Medicine and Hygiene</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by/4.0/</License> <Keyword>Virology</Keyword> <Keyword>Infectious Diseases</Keyword> <Keyword>Parasitology</Keyword> <Abstract>Alphaviruses (Togaviridae, Alphavirus) are arthropod-borne single-stranded RNA pathogens that cause febrile and neurologic disease in much of Latin America. However, many features of Alphavirus epidemiology remain unknown. In 2011, we undertook a cross-sectional study in Nueva Esperanza, an indigenous community in the Peruvian Amazon. Here, we present the first serologic evidence of Mayaro (MAYV), Venezuelan equine encephalitis (VEE) complex alphavirus, Una (UNAV), and Madariaga (MADV) viruses reported in humans (24%, 16%, 13%, and 1.5%, respectively) fromanAmazonian indigenous community in Peru. Hunting activity and cohabiting with hunters were the main risk factors for Mayaro seroconversion, butonly huntingwas associated with UNAVseropositivity. Ourresults suggest that alphavirus infection in this region is common, but we highlight the high UNAV seroprevalence found and corroborate the low MADV prevalence reportedinthis region. Furthermore, MAYV-neutralizing antibodies were also detected instored samples from wild animals (18%) hunted by Nueva Esperanza inhabitants and another mestizo community located close to Iquitos. Further serological surveys of VEE complex alphaviruses, UNAV, and MADV in wild animals and assessing the ability of the MAYV seropositive species to transmit the virus will be relevant. Copyright © 2019 by The American Society of Tropical Medicine and Hygiene.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.023852
Serologic evidence of zoonotic alphaviruses in humans from an indigenous community in the Peruvian Amazon
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