Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru

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This work was supported by the National Institutes of Health (NIH) 5D43TW009349–03 “Inter-American Training for Innovations in Emerging Infectious Diseases” (to GOL). F. S. was supported by FONDECYT-CONCYTEC (grant contract number 246–2015-FONDECYT), and the UJMT Fogarty Global Health Fellows Consor...

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Autores: Schiaffino, Francesca, Lee, Gwenyth O., Paredes-Olortegui, Maribel, Cabrera, Lilia, Penataro-Yor, Pablo, Gilman, Robert H., Kosek, Margaret N.
Formato: artículo
Fecha de Publicación:2019
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/2749
Enlace del recurso:https://hdl.handle.net/20.500.12390/2749
https://doi.org/10.1055/s-0038-1676614
Nivel de acceso:acceso abierto
Materia:tuberculosis
Bacillus Calmette-Guerin
Peru
preterm births
http://purl.org/pe-repo/ocde/ford#3.01.03
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network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru
title Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru
spellingShingle Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru
Schiaffino, Francesca
tuberculosis
Bacillus Calmette-Guerin
Peru
preterm births
http://purl.org/pe-repo/ocde/ford#3.01.03
title_short Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru
title_full Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru
title_fullStr Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru
title_full_unstemmed Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru
title_sort Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru
author Schiaffino, Francesca
author_facet Schiaffino, Francesca
Lee, Gwenyth O.
Paredes-Olortegui, Maribel
Cabrera, Lilia
Penataro-Yor, Pablo
Gilman, Robert H.
Kosek, Margaret N.
author_role author
author2 Lee, Gwenyth O.
Paredes-Olortegui, Maribel
Cabrera, Lilia
Penataro-Yor, Pablo
Gilman, Robert H.
Kosek, Margaret N.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schiaffino, Francesca
Lee, Gwenyth O.
Paredes-Olortegui, Maribel
Cabrera, Lilia
Penataro-Yor, Pablo
Gilman, Robert H.
Kosek, Margaret N.
dc.subject.none.fl_str_mv tuberculosis
topic tuberculosis
Bacillus Calmette-Guerin
Peru
preterm births
http://purl.org/pe-repo/ocde/ford#3.01.03
dc.subject.es_PE.fl_str_mv Bacillus Calmette-Guerin
Peru
preterm births
dc.subject.ocde.none.fl_str_mv http://purl.org/pe-repo/ocde/ford#3.01.03
description This work was supported by the National Institutes of Health (NIH) 5D43TW009349–03 “Inter-American Training for Innovations in Emerging Infectious Diseases” (to GOL). F. S. was supported by FONDECYT-CONCYTEC (grant contract number 246–2015-FONDECYT), and the UJMT Fogarty Global Health Fellows Consortium comprising Johns Hopkins University, the University of North Carolina, Morehouse University, and Tulane University (NIH Research Training Grant # D43 TW009340 funded by the NIH Fogarty International Center, NINDS, NIMH, NHBLI and NIEHS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/2749
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1055/s-0038-1676614
dc.identifier.scopus.none.fl_str_mv 2-s2.0-85072904453
url https://hdl.handle.net/20.500.12390/2749
https://doi.org/10.1055/s-0038-1676614
identifier_str_mv 2-s2.0-85072904453
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv American Journal of Perinatology
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Thieme Medical Publishers, Inc.
publisher.none.fl_str_mv Thieme Medical Publishers, Inc.
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
_version_ 1839175414911598592
spelling Publicationrp00715600rp07362600rp00719600rp01174600rp07363600rp00604600rp00721600Schiaffino, FrancescaLee, Gwenyth O.Paredes-Olortegui, MaribelCabrera, LiliaPenataro-Yor, PabloGilman, Robert H.Kosek, Margaret N.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2019https://hdl.handle.net/20.500.12390/2749https://doi.org/10.1055/s-0038-16766142-s2.0-85072904453This work was supported by the National Institutes of Health (NIH) 5D43TW009349–03 “Inter-American Training for Innovations in Emerging Infectious Diseases” (to GOL). F. S. was supported by FONDECYT-CONCYTEC (grant contract number 246–2015-FONDECYT), and the UJMT Fogarty Global Health Fellows Consortium comprising Johns Hopkins University, the University of North Carolina, Morehouse University, and Tulane University (NIH Research Training Grant # D43 TW009340 funded by the NIH Fogarty International Center, NINDS, NIMH, NHBLI and NIEHS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Background Bacillus Calmette-Guerin (BCG) scar formation is considered a visual marker of vaccination and cell-mediated immune response. This study characterized the association between pregnancy and birth characteristics with BCG scar formation. Study Design Pregnant women were enrolled prospectively. Infants were followed up for the first 6 months of life, and the diameter of the BCG scar was recorded. Marginal models were fitted to assess the association of BCG scar diameter with pregnancy and birth characteristics using linear regressions with generalized estimating equations. Results A total of 307 infants were enrolled, of whom 19.2% (59/307) were of low birth weight. Among those with known gestational age, 7.1% were preterm births (21/295). Overall, 98.7% (303/307) of infants developed a BCG scar. BCG scar trends in a tropical environment, such as the Amazon, differ from the trends evidenced in the capital of Peru. For every additional week of gestational age, the mean scar diameter increased by 0.1 mm (95% confidence interval [CI]: 0.02, 0.24; p = 0.017). Maternal illness during pregnancy impacted BCG scar size, as the infants of mothers who self-report fever had a smaller scar diameter (1 mm, 95% CI: 0.5, 1.8 mm; p = 0.001). Conclusion The immune reaction to the BCG vaccination is affected by gestational age at birth and systemic inflammatory episodes during pregnancy. © 2019 Georg Thieme Verlag KG Stuttgart New York.Fondo Nacional de Desarrollo Científico y Tecnológico - FondecytengThieme Medical Publishers, Inc.American Journal of Perinatologyinfo:eu-repo/semantics/openAccesstuberculosisBacillus Calmette-Guerin-1Peru-1preterm births-1http://purl.org/pe-repo/ocde/ford#3.01.03-1Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peruinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/2749oai:repositorio.concytec.gob.pe:20.500.12390/27492024-05-30 15:25:28.671http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="0ce05b5e-04a1-4ae3-898b-258f52561d89"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru</Title> <PublishedIn> <Publication> <Title>American Journal of Perinatology</Title> </Publication> </PublishedIn> <PublicationDate>2019</PublicationDate> <DOI>https://doi.org/10.1055/s-0038-1676614</DOI> <SCP-Number>2-s2.0-85072904453</SCP-Number> <Authors> <Author> <DisplayName>Schiaffino, Francesca</DisplayName> <Person id="rp00715" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Lee, Gwenyth O.</DisplayName> <Person id="rp07362" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Paredes-Olortegui, Maribel</DisplayName> <Person id="rp00719" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Cabrera, Lilia</DisplayName> <Person id="rp01174" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Penataro-Yor, Pablo</DisplayName> <Person id="rp07363" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gilman, Robert H.</DisplayName> <Person id="rp00604" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Kosek, Margaret N.</DisplayName> <Person id="rp00721" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Thieme Medical Publishers, Inc.</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>tuberculosis</Keyword> <Keyword>Bacillus Calmette-Guerin</Keyword> <Keyword>Peru</Keyword> <Keyword>preterm births</Keyword> <Abstract>Background Bacillus Calmette-Guerin (BCG) scar formation is considered a visual marker of vaccination and cell-mediated immune response. This study characterized the association between pregnancy and birth characteristics with BCG scar formation. Study Design Pregnant women were enrolled prospectively. Infants were followed up for the first 6 months of life, and the diameter of the BCG scar was recorded. Marginal models were fitted to assess the association of BCG scar diameter with pregnancy and birth characteristics using linear regressions with generalized estimating equations. Results A total of 307 infants were enrolled, of whom 19.2% (59/307) were of low birth weight. Among those with known gestational age, 7.1% were preterm births (21/295). Overall, 98.7% (303/307) of infants developed a BCG scar. BCG scar trends in a tropical environment, such as the Amazon, differ from the trends evidenced in the capital of Peru. For every additional week of gestational age, the mean scar diameter increased by 0.1 mm (95% confidence interval [CI]: 0.02, 0.24; p = 0.017). Maternal illness during pregnancy impacted BCG scar size, as the infants of mothers who self-report fever had a smaller scar diameter (1 mm, 95% CI: 0.5, 1.8 mm; p = 0.001). Conclusion The immune reaction to the BCG vaccination is affected by gestational age at birth and systemic inflammatory episodes during pregnancy. © 2019 Georg Thieme Verlag KG Stuttgart New York.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.448654
Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru
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