Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice

Descripción del Articulo

National Nature Science Foundation of China, NSFC in 2004 (30472016/C03020701); International Technologic Collaboration Project, grant no. 2006DFA21740; Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2005.
Detalles Bibliográficos
Autores: Rubio, JL, Qiong, W, Liu, XM, Jiang, Z, Dang, HX, Chen, SL, Gonzales, GF
Formato: artículo
Fecha de Publicación:2011
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/1227
Enlace del recurso:https://hdl.handle.net/20.500.12390/1227
https://doi.org/10.1093/ecam/nen063
Nivel de acceso:acceso abierto
Materia:Trastornos de la Memoria
Experimentación Animal
Ovariectomía
https://purl.org/pe-repo/ocde/ford#1.06.11
id CONC_d970d196060524dc10bb84ab89da753f
oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/1227
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
title Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
spellingShingle Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
Rubio, JL
Trastornos de la Memoria
Experimentación Animal
Ovariectomía
https://purl.org/pe-repo/ocde/ford#1.06.11
title_short Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
title_full Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
title_fullStr Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
title_full_unstemmed Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
title_sort Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
author Rubio, JL
author_facet Rubio, JL
Qiong, W
Liu, XM
Jiang, Z
Dang, HX
Chen, SL
Gonzales, GF
author_role author
author2 Qiong, W
Liu, XM
Jiang, Z
Dang, HX
Chen, SL
Gonzales, GF
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rubio, JL
Qiong, W
Liu, XM
Jiang, Z
Dang, HX
Chen, SL
Gonzales, GF
dc.subject.none.fl_str_mv Trastornos de la Memoria
topic Trastornos de la Memoria
Experimentación Animal
Ovariectomía
https://purl.org/pe-repo/ocde/ford#1.06.11
dc.subject.es_PE.fl_str_mv Experimentación Animal
Ovariectomía
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#1.06.11
description National Nature Science Foundation of China, NSFC in 2004 (30472016/C03020701); International Technologic Collaboration Project, grant no. 2006DFA21740; Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2005.
publishDate 2011
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/1227
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1093/ecam/nen063
dc.identifier.isi.none.fl_str_mv 293405400001
url https://hdl.handle.net/20.500.12390/1227
https://doi.org/10.1093/ecam/nen063
identifier_str_mv 293405400001
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Evidence-Based Complementary and Alternative Medicine
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
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spelling Publicationrp03507600rp03505600rp03506600rp03504600rp03508600rp01871500rp00575500Rubio, JLQiong, WLiu, XMJiang, ZDang, HXChen, SLGonzales, GF2024-05-30T23:13:38Z2024-05-30T23:13:38Z2011https://hdl.handle.net/20.500.12390/1227https://doi.org/10.1093/ecam/nen063293405400001National Nature Science Foundation of China, NSFC in 2004 (30472016/C03020701); International Technologic Collaboration Project, grant no. 2006DFA21740; Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2005.The present study aims to test two different doses of aqueous extract of black maca on learning and memory in ovariectomized (OVX) mice and their relation with malonalehyde (MDA), acetylcholinesterase (Ache) and monoamine oxidase (MAO) brain levels. Female mice were divided into five groups: (i) naive (control), (ii) sham, (iii) OVX mice and OVX mice treated with (iv) 0.50 g kg-1 and (v) 2.00 g kg-1 blackmaca.Mice were orally treated with distilled water or blackmaca during 35 days starting 7 days after surgery. Memory and learning were assessed using the water Morris maze (from day 23-27) and the step-down avoidance test (days 34 and 35). At the end of each treatment, mice were sacrificed by decapitation and brains were dissected out for MDA, Ache andMAO determinations. Black maca (0.5 and 2.0 g/kg) increased step-down latency when compared to OVX control mice. Black maca decreased MDA and Ache levels in OVX mice; whereas, no differences were observed in MAO levels. Finally, black maca improved experimental memory impairment induced by ovariectomy, due in part, by its antioxidant and Ache inhibitory activities.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengHindawiEvidence-Based Complementary and Alternative Medicineinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/Trastornos de la MemoriaExperimentación Animal-1Ovariectomía-1https://purl.org/pe-repo/ocde/ford#1.06.11-1Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Miceinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/1227oai:repositorio.concytec.gob.pe:20.500.12390/12272024-05-30 16:01:55.723https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="3d211e3f-55e3-4e76-9f36-4e06fed4e328"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice</Title> <PublishedIn> <Publication> <Title>Evidence-Based Complementary and Alternative Medicine</Title> </Publication> </PublishedIn> <PublicationDate>2011</PublicationDate> <DOI>https://doi.org/10.1093/ecam/nen063</DOI> <ISI-Number>293405400001</ISI-Number> <Authors> <Author> <DisplayName>Rubio, JL</DisplayName> <Person id="rp03507" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Qiong, W</DisplayName> <Person id="rp03505" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Liu, XM</DisplayName> <Person id="rp03506" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Jiang, Z</DisplayName> <Person id="rp03504" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Dang, HX</DisplayName> <Person id="rp03508" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chen, SL</DisplayName> <Person id="rp01871" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gonzales, GF</DisplayName> <Person id="rp00575" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Hindawi</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by-nc-nd/4.0/</License> <Keyword>Trastornos de la Memoria</Keyword> <Keyword>Experimentación Animal</Keyword> <Keyword>Ovariectomía</Keyword> <Abstract>The present study aims to test two different doses of aqueous extract of black maca on learning and memory in ovariectomized (OVX) mice and their relation with malonalehyde (MDA), acetylcholinesterase (Ache) and monoamine oxidase (MAO) brain levels. Female mice were divided into five groups: (i) naive (control), (ii) sham, (iii) OVX mice and OVX mice treated with (iv) 0.50 g kg-1 and (v) 2.00 g kg-1 blackmaca.Mice were orally treated with distilled water or blackmaca during 35 days starting 7 days after surgery. Memory and learning were assessed using the water Morris maze (from day 23-27) and the step-down avoidance test (days 34 and 35). At the end of each treatment, mice were sacrificed by decapitation and brains were dissected out for MDA, Ache andMAO determinations. Black maca (0.5 and 2.0 g/kg) increased step-down latency when compared to OVX control mice. Black maca decreased MDA and Ache levels in OVX mice; whereas, no differences were observed in MAO levels. Finally, black maca improved experimental memory impairment induced by ovariectomy, due in part, by its antioxidant and Ache inhibitory activities.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.856838
Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice
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