Penicillin resistance and serotypes/serogroups of Streptococcus pneumoniae in nasopharyngeal carrier children younger than 2 years in Lima, Peru

• Autores: Ochoa T.J., Rupa R., Guerra H., Hernandez H., Chaparro E., Tamariz J., Wanger A., Mason Jr. E.O.
• Formato: artículo
• Fecha de Publicación: 2005
• Institución: Consejo Nacional de Ciencia Tecnología e Innovación
• Repositorio: CONCYTEC-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.concytec.gob.pe:20.500.12390/732
• Enlace del recurso: https://hdl.handle.net/20.500.12390/732; https://doi.org/10.1016/j.diagmicrobio.2004.12.014
• Nivel de acceso: acceso abierto
• Materia: Pneumococcus vaccine; ceftriaxone; chloramphenicol; clindamycin; cotrimoxazole; erythromycin; penicillin G; article; bacterial strain; bacterium isolate; bacterium isolation; blood group typing; https://purl.org/pe-repo/ocde/ford#3.02.03

The purpose of this study was to determine the carriage rate, susceptibility pattern, and serotype distribution of Streptococcus pneumoniae in the nasopharynx of children younger than 2 years old in Lima, Peru. A total of 666 children were evaluated during 3 periods, 1997, 2001, and 2003. The overall pneumococcal carrier rate was 41%. Reduced susceptibility to penicillin was found in 5% (4/75) of isolates in 1997, 20% (15/75) in 2001, and 37% (40/109) in 2003. Reduced susceptibility to ceftriaxone was found in 12% of isolates in 2003. Serogroups 6, 19, 23, 15, and 14 accounted for 68% of all the isolates and for 81% of the penicillin-nonsusceptible strains. Only 65% of the isolated strains had serogroups found in the 7-valent conjugate pneumococcal vaccine. This highlights the importance of regional surveillance studies for effective vaccine strategies and treatment protocols.