A proposal of excipients mixture for the elaboration of Na131I capsules
Descripción del Articulo
The authors are grateful for the financial support of the Fondo Nacional de Desarrollo Cient?fico Tecnol?gico y de Innovaci?n (FONDECYT) and to the staff of Analytical Techniques Laboratory and the Radioisotope Production Plant for their contributions.
| Autores: | , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2020 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/2293 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/2293 https://doi.org/10.1007/s10967-020-07255-w |
| Nivel de acceso: | acceso abierto |
| Materia: | Thyroid therapy Na131I capsules Radioiodine capsules Thyroid gland http://purl.org/pe-repo/ocde/ford#2.04.01 |
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CONC_a1a638b90b7a1d010979b3a9e1a5194b |
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oai:repositorio.concytec.gob.pe:20.500.12390/2293 |
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CONC |
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CONCYTEC-Institucional |
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4689 |
| dc.title.none.fl_str_mv |
A proposal of excipients mixture for the elaboration of Na131I capsules |
| title |
A proposal of excipients mixture for the elaboration of Na131I capsules |
| spellingShingle |
A proposal of excipients mixture for the elaboration of Na131I capsules Alviar M. Thyroid therapy Na131I capsules Radioiodine capsules Thyroid gland http://purl.org/pe-repo/ocde/ford#2.04.01 |
| title_short |
A proposal of excipients mixture for the elaboration of Na131I capsules |
| title_full |
A proposal of excipients mixture for the elaboration of Na131I capsules |
| title_fullStr |
A proposal of excipients mixture for the elaboration of Na131I capsules |
| title_full_unstemmed |
A proposal of excipients mixture for the elaboration of Na131I capsules |
| title_sort |
A proposal of excipients mixture for the elaboration of Na131I capsules |
| author |
Alviar M. |
| author_facet |
Alviar M. Miranda J. Bedregal P. |
| author_role |
author |
| author2 |
Miranda J. Bedregal P. |
| author2_role |
author author |
| dc.contributor.author.fl_str_mv |
Alviar M. Miranda J. Bedregal P. |
| dc.subject.none.fl_str_mv |
Thyroid therapy |
| topic |
Thyroid therapy Na131I capsules Radioiodine capsules Thyroid gland http://purl.org/pe-repo/ocde/ford#2.04.01 |
| dc.subject.es_PE.fl_str_mv |
Na131I capsules Radioiodine capsules Thyroid gland |
| dc.subject.ocde.none.fl_str_mv |
http://purl.org/pe-repo/ocde/ford#2.04.01 |
| description |
The authors are grateful for the financial support of the Fondo Nacional de Desarrollo Cient?fico Tecnol?gico y de Innovaci?n (FONDECYT) and to the staff of Analytical Techniques Laboratory and the Radioisotope Production Plant for their contributions. |
| publishDate |
2020 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/2293 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1007/s10967-020-07255-w |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85089917933 |
| url |
https://hdl.handle.net/20.500.12390/2293 https://doi.org/10.1007/s10967-020-07255-w |
| identifier_str_mv |
2-s2.0-85089917933 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Journal of Radioanalytical and Nuclear Chemistry |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Springer Science and Business Media B.V. |
| publisher.none.fl_str_mv |
Springer Science and Business Media B.V. |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
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Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844882992142483456 |
| spelling |
Publicationrp05420600rp05421600rp05422600Alviar M.Miranda J.Bedregal P.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2020https://hdl.handle.net/20.500.12390/2293https://doi.org/10.1007/s10967-020-07255-w2-s2.0-85089917933The authors are grateful for the financial support of the Fondo Nacional de Desarrollo Cient?fico Tecnol?gico y de Innovaci?n (FONDECYT) and to the staff of Analytical Techniques Laboratory and the Radioisotope Production Plant for their contributions.Since the use of radioiodine for thyroid therapy in the form of an oral solution has risks associated with contamination, the need to develop suitable Na131I capsules has attracted significant attention. A series of different mass combinations of excipients was prepared using ascorbic acid, sodium thiosulphate, mannitol, maltose, magnesium sulphate, lactose, dextrose, sodium phosphate, and sucrose. These compounds were tested for their volatility and oxidation profile. Two of the excipient mixtures were selected to prepare capsules due to their high stability and low volatility. The experiments performed to evaluate a new excipients mixture are described in this manuscript. © 2020, Akadémiai Kiadó, Budapest, Hungary.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengSpringer Science and Business Media B.V.Journal of Radioanalytical and Nuclear Chemistryinfo:eu-repo/semantics/openAccessThyroid therapyNa131I capsules-1Radioiodine capsules-1Thyroid gland-1http://purl.org/pe-repo/ocde/ford#2.04.01-1A proposal of excipients mixture for the elaboration of Na131I capsulesinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/2293oai:repositorio.concytec.gob.pe:20.500.12390/22932024-05-30 16:06:58.295http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="80102f71-7c65-4621-aea8-ea6789404a86"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>A proposal of excipients mixture for the elaboration of Na131I capsules</Title> <PublishedIn> <Publication> <Title>Journal of Radioanalytical and Nuclear Chemistry</Title> </Publication> </PublishedIn> <PublicationDate>2020</PublicationDate> <DOI>https://doi.org/10.1007/s10967-020-07255-w</DOI> <SCP-Number>2-s2.0-85089917933</SCP-Number> <Authors> <Author> <DisplayName>Alviar M.</DisplayName> <Person id="rp05420" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Miranda J.</DisplayName> <Person id="rp05421" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Bedregal P.</DisplayName> <Person id="rp05422" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Springer Science and Business Media B.V.</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>Thyroid therapy</Keyword> <Keyword>Na131I capsules</Keyword> <Keyword>Radioiodine capsules</Keyword> <Keyword>Thyroid gland</Keyword> <Abstract>Since the use of radioiodine for thyroid therapy in the form of an oral solution has risks associated with contamination, the need to develop suitable Na131I capsules has attracted significant attention. A series of different mass combinations of excipients was prepared using ascorbic acid, sodium thiosulphate, mannitol, maltose, magnesium sulphate, lactose, dextrose, sodium phosphate, and sucrose. These compounds were tested for their volatility and oxidation profile. Two of the excipient mixtures were selected to prepare capsules due to their high stability and low volatility. The experiments performed to evaluate a new excipients mixture are described in this manuscript. © 2020, Akadémiai Kiadó, Budapest, Hungary.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.40239 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
