In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system
Descripción del Articulo
This research was funded by FONDECYT-CONCYTEC (grant contract number 238-2015-FONDECYT). We want to acknowledge Dr Marco Lopez from INSERM U1008 for SEM analyses.
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2019 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/652 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/652 https://doi.org/10.1016/j.ijpharm.2018.12.018 |
| Nivel de acceso: | acceso abierto |
| Materia: | silver derivative antiinfective agent chitosan citric acid cross linking reagent cyclodextrin polyelectrolyte chemistry drug effect https://purl.org/pe-repo/ocde/ford#3.02.00 |
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CONC_884763873f558fbee648924a0e03fe1a |
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oai:repositorio.concytec.gob.pe:20.500.12390/652 |
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CONC |
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CONCYTEC-Institucional |
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4689 |
| dc.title.none.fl_str_mv |
In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system |
| title |
In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system |
| spellingShingle |
In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system Mogrovejo-Valdivia A. silver derivative antiinfective agent chitosan citric acid cross linking reagent cyclodextrin polyelectrolyte chemistry drug effect https://purl.org/pe-repo/ocde/ford#3.02.00 |
| title_short |
In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system |
| title_full |
In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system |
| title_fullStr |
In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system |
| title_full_unstemmed |
In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system |
| title_sort |
In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system |
| author |
Mogrovejo-Valdivia A. |
| author_facet |
Mogrovejo-Valdivia A. Rahmouni O. Tabary N. Maton M. Neut C. Martel B. Blanchemain N. |
| author_role |
author |
| author2 |
Rahmouni O. Tabary N. Maton M. Neut C. Martel B. Blanchemain N. |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Mogrovejo-Valdivia A. Rahmouni O. Tabary N. Maton M. Neut C. Martel B. Blanchemain N. |
| dc.subject.none.fl_str_mv |
silver derivative |
| topic |
silver derivative antiinfective agent chitosan citric acid cross linking reagent cyclodextrin polyelectrolyte chemistry drug effect https://purl.org/pe-repo/ocde/ford#3.02.00 |
| dc.subject.es_PE.fl_str_mv |
antiinfective agent chitosan citric acid cross linking reagent cyclodextrin polyelectrolyte chemistry drug effect |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.02.00 |
| description |
This research was funded by FONDECYT-CONCYTEC (grant contract number 238-2015-FONDECYT). We want to acknowledge Dr Marco Lopez from INSERM U1008 for SEM analyses. |
| publishDate |
2019 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/652 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.ijpharm.2018.12.018 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-85058800331 |
| url |
https://hdl.handle.net/20.500.12390/652 https://doi.org/10.1016/j.ijpharm.2018.12.018 |
| identifier_str_mv |
2-s2.0-85058800331 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
International Journal of Pharmaceutics |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
| publisher.none.fl_str_mv |
Elsevier B.V. |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883030279192576 |
| spelling |
Publicationrp01190500rp01372600rp01188500rp01191500rp01194500rp01189500rp01193500Mogrovejo-Valdivia A.Rahmouni O.Tabary N.Maton M.Neut C.Martel B.Blanchemain N.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2019https://hdl.handle.net/20.500.12390/652https://doi.org/10.1016/j.ijpharm.2018.12.0182-s2.0-85058800331This research was funded by FONDECYT-CONCYTEC (grant contract number 238-2015-FONDECYT). We want to acknowledge Dr Marco Lopez from INSERM U1008 for SEM analyses.The goal of the study was to elaborate an antibacterial silver wound dressing covered by a protective coating that would prevent silver diffusion toward skin without losing its biocide properties. Therefore, non woven polyethyleneterephtalate (PET) textiles were pre-treated by two types of polysaccharides - chitosan and cyclodextrin - both crosslinked with citric acid by a pad/dry/cure process. Both types of resulting thermofixed textiles carrying the citrate crosslinks were then impregnated in silver solution followed by a thermal treatment and were finally coated by Layer-by-Layer (L-b-L) deposition of a polyelectrolyte multilayer (PEM) film consisting of anionic water-soluble poly-cyclodextrin and cationic chitosan. The influence of the process parameters was investigated in terms of silver adsorption capacity, PEM system build-up, silver kinetics of release and antibacterial activity. We demonstrate i) the utility of the intermediate thermal treatment step in the reduction of silver leakage in the polyelectrolyte solutions used in the L-b-L process, ii) that silver adsorption on the preliminary thermofixed layers did not affect the PEM system build-up, iii) the slowing down of silver release kinetic thanks to the PEM coating, iv) the preservation of the antibacterial activity despite the PEM coating.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengElsevier B.V.International Journal of Pharmaceuticsinfo:eu-repo/semantics/openAccesssilver derivativeantiinfective agent-1chitosan-1citric acid-1cross linking reagent-1cyclodextrin-1polyelectrolyte-1chemistry-1drug effect-1https://purl.org/pe-repo/ocde/ford#3.02.00-1In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer systeminfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/652oai:repositorio.concytec.gob.pe:20.500.12390/6522024-05-30 15:22:33.508http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="cb7083c0-4841-4b85-817d-5768a15375e3"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system</Title> <PublishedIn> <Publication> <Title>International Journal of Pharmaceutics</Title> </Publication> </PublishedIn> <PublicationDate>2019</PublicationDate> <DOI>https://doi.org/10.1016/j.ijpharm.2018.12.018</DOI> <SCP-Number>2-s2.0-85058800331</SCP-Number> <Authors> <Author> <DisplayName>Mogrovejo-Valdivia A.</DisplayName> <Person id="rp01190" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Rahmouni O.</DisplayName> <Person id="rp01372" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Tabary N.</DisplayName> <Person id="rp01188" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Maton M.</DisplayName> <Person id="rp01191" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Neut C.</DisplayName> <Person id="rp01194" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Martel B.</DisplayName> <Person id="rp01189" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Blanchemain N.</DisplayName> <Person id="rp01193" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Elsevier B.V.</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>silver derivative</Keyword> <Keyword>antiinfective agent</Keyword> <Keyword>chitosan</Keyword> <Keyword>citric acid</Keyword> <Keyword>cross linking reagent</Keyword> <Keyword>cyclodextrin</Keyword> <Keyword>polyelectrolyte</Keyword> <Keyword>chemistry</Keyword> <Keyword>drug effect</Keyword> <Abstract>The goal of the study was to elaborate an antibacterial silver wound dressing covered by a protective coating that would prevent silver diffusion toward skin without losing its biocide properties. Therefore, non woven polyethyleneterephtalate (PET) textiles were pre-treated by two types of polysaccharides - chitosan and cyclodextrin - both crosslinked with citric acid by a pad/dry/cure process. Both types of resulting thermofixed textiles carrying the citrate crosslinks were then impregnated in silver solution followed by a thermal treatment and were finally coated by Layer-by-Layer (L-b-L) deposition of a polyelectrolyte multilayer (PEM) film consisting of anionic water-soluble poly-cyclodextrin and cationic chitosan. The influence of the process parameters was investigated in terms of silver adsorption capacity, PEM system build-up, silver kinetics of release and antibacterial activity. We demonstrate i) the utility of the intermediate thermal treatment step in the reduction of silver leakage in the polyelectrolyte solutions used in the L-b-L process, ii) that silver adsorption on the preliminary thermofixed layers did not affect the PEM system build-up, iii) the slowing down of silver release kinetic thanks to the PEM coating, iv) the preservation of the antibacterial activity despite the PEM coating.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.36089 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
