Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease
Descripción del Articulo
This research was funded by Consejo Nacional de Ciencia, Tecnologia e Innovacion Tecnologica de Peru (grant N~ 024-2019-Fondecyt-BM-INC.INV and CONCYTEC-FONDECYT-E038-01).
| Autores: | , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2021 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/2951 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/2951 https://doi.org/10.1016/j.isci.2021.102993 |
| Nivel de acceso: | acceso abierto |
| Materia: | Omics Molecular neuroscience Immunology https://purl.org/pe-repo/ocde/ford#3.02.25 |
| id |
CONC_86dea3b6c2d79071b427e27fd1d195b2 |
|---|---|
| oai_identifier_str |
oai:repositorio.concytec.gob.pe:20.500.12390/2951 |
| network_acronym_str |
CONC |
| network_name_str |
CONCYTEC-Institucional |
| repository_id_str |
4689 |
| dc.title.none.fl_str_mv |
Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease |
| title |
Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease |
| spellingShingle |
Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease Aguilar-Pineda, Jorge A. Omics Molecular neuroscience Immunology https://purl.org/pe-repo/ocde/ford#3.02.25 |
| title_short |
Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease |
| title_full |
Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease |
| title_fullStr |
Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease |
| title_full_unstemmed |
Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease |
| title_sort |
Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease |
| author |
Aguilar-Pineda, Jorge A. |
| author_facet |
Aguilar-Pineda, Jorge A. Vera-Lopez, Karin J. Shrivastava, Pallavi Chavez-Fumagalli, Miguel A. Nieto-Montesinos, Rita Alvarez-Fernandez, Karla L. Goyzueta Mamani, Luis D. Davila Del-Carpio, Gonzalo Gomez-Valdez, Badhin Miller, Clint L. Malhotra, Rajeev Lindsay, Mark E. Lino Cardenas, Christian L. |
| author_role |
author |
| author2 |
Vera-Lopez, Karin J. Shrivastava, Pallavi Chavez-Fumagalli, Miguel A. Nieto-Montesinos, Rita Alvarez-Fernandez, Karla L. Goyzueta Mamani, Luis D. Davila Del-Carpio, Gonzalo Gomez-Valdez, Badhin Miller, Clint L. Malhotra, Rajeev Lindsay, Mark E. Lino Cardenas, Christian L. |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Aguilar-Pineda, Jorge A. Vera-Lopez, Karin J. Shrivastava, Pallavi Chavez-Fumagalli, Miguel A. Nieto-Montesinos, Rita Alvarez-Fernandez, Karla L. Goyzueta Mamani, Luis D. Davila Del-Carpio, Gonzalo Gomez-Valdez, Badhin Miller, Clint L. Malhotra, Rajeev Lindsay, Mark E. Lino Cardenas, Christian L. |
| dc.subject.none.fl_str_mv |
Omics |
| topic |
Omics Molecular neuroscience Immunology https://purl.org/pe-repo/ocde/ford#3.02.25 |
| dc.subject.es_PE.fl_str_mv |
Molecular neuroscience Immunology |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.02.25 |
| description |
This research was funded by Consejo Nacional de Ciencia, Tecnologia e Innovacion Tecnologica de Peru (grant N~ 024-2019-Fondecyt-BM-INC.INV and CONCYTEC-FONDECYT-E038-01). |
| publishDate |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/2951 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.isci.2021.102993 |
| url |
https://hdl.handle.net/20.500.12390/2951 https://doi.org/10.1016/j.isci.2021.102993 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
ISCIENCE |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.uri.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.publisher.none.fl_str_mv |
Cell Press |
| publisher.none.fl_str_mv |
Cell Press |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883018910531584 |
| spelling |
Publicationrp08346600rp08192600rp08182600rp08341600rp08188600rp08340600rp08347600rp08186600rp08345600rp08342600rp08343600rp08344600rp08183600Aguilar-Pineda, Jorge A.Vera-Lopez, Karin J.Shrivastava, PallaviChavez-Fumagalli, Miguel A.Nieto-Montesinos, RitaAlvarez-Fernandez, Karla L.Goyzueta Mamani, Luis D.Davila Del-Carpio, GonzaloGomez-Valdez, BadhinMiller, Clint L.Malhotra, RajeevLindsay, Mark E.Lino Cardenas, Christian L.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2021https://hdl.handle.net/20.500.12390/2951https://doi.org/10.1016/j.isci.2021.102993This research was funded by Consejo Nacional de Ciencia, Tecnologia e Innovacion Tecnologica de Peru (grant N~ 024-2019-Fondecyt-BM-INC.INV and CONCYTEC-FONDECYT-E038-01).Despite the emerging evidence implying early vascular contributions to neurode-generative syndromes, the role of vascular smooth muscle cells (VSMCs) in the pathogenesis of Alzheimer disease (AD) is still not well understood. Herein, we show that VSMCs in brains of patients with AD and animal models of the disease are deficient in multiple VSMC contractile markers which correlated with Tau accumulation in brain arterioles. Ex vivo and in vitro experiments demonstrated that VSMCs undergo dramatic phenotypic transitions under AD-like conditions, adopting pro-inflammatory phenotypes. Notably, these changes coincided with Tau hyperphosphorylation at residues Y18, T205, and S262. We also observed that VSMC dysfunction occurred in an age-dependent manner and that expression of Sm22a protein was inversely correlated with CD68 and Tau expression in brain arterioles of the 3xTg-AD and 5xFAD mice. Together, these findings further support the contribution of dysfunctional VSMCs in AD pathogenesis and nominate VSMCs as a potential therapeutic target in AD.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengCell PressISCIENCEinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/OmicsMolecular neuroscience-1Immunology-1https://purl.org/pe-repo/ocde/ford#3.02.25-1Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer diseaseinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/2951oai:repositorio.concytec.gob.pe:20.500.12390/29512024-05-30 16:12:25.93https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="b5b18811-5cdb-488a-a9a7-fdb1f1e6afa8"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease</Title> <PublishedIn> <Publication> <Title>ISCIENCE</Title> </Publication> </PublishedIn> <PublicationDate>2021</PublicationDate> <DOI>https://doi.org/10.1016/j.isci.2021.102993</DOI> <Authors> <Author> <DisplayName>Aguilar-Pineda, Jorge A.</DisplayName> <Person id="rp08346" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Vera-Lopez, Karin J.</DisplayName> <Person id="rp08192" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Shrivastava, Pallavi</DisplayName> <Person id="rp08182" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chavez-Fumagalli, Miguel A.</DisplayName> <Person id="rp08341" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Nieto-Montesinos, Rita</DisplayName> <Person id="rp08188" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Alvarez-Fernandez, Karla L.</DisplayName> <Person id="rp08340" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Goyzueta Mamani, Luis D.</DisplayName> <Person id="rp08347" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Davila Del-Carpio, Gonzalo</DisplayName> <Person id="rp08186" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gomez-Valdez, Badhin</DisplayName> <Person id="rp08345" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Miller, Clint L.</DisplayName> <Person id="rp08342" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Malhotra, Rajeev</DisplayName> <Person id="rp08343" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Lindsay, Mark E.</DisplayName> <Person id="rp08344" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Lino Cardenas, Christian L.</DisplayName> <Person id="rp08183" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Cell Press</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by-nc-nd/4.0/</License> <Keyword>Omics</Keyword> <Keyword>Molecular neuroscience</Keyword> <Keyword>Immunology</Keyword> <Abstract>Despite the emerging evidence implying early vascular contributions to neurode-generative syndromes, the role of vascular smooth muscle cells (VSMCs) in the pathogenesis of Alzheimer disease (AD) is still not well understood. Herein, we show that VSMCs in brains of patients with AD and animal models of the disease are deficient in multiple VSMC contractile markers which correlated with Tau accumulation in brain arterioles. Ex vivo and in vitro experiments demonstrated that VSMCs undergo dramatic phenotypic transitions under AD-like conditions, adopting pro-inflammatory phenotypes. Notably, these changes coincided with Tau hyperphosphorylation at residues Y18, T205, and S262. We also observed that VSMC dysfunction occurred in an age-dependent manner and that expression of Sm22a protein was inversely correlated with CD68 and Tau expression in brain arterioles of the 3xTg-AD and 5xFAD mice. Together, these findings further support the contribution of dysfunctional VSMCs in AD pathogenesis and nominate VSMCs as a potential therapeutic target in AD.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.476704 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
