Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark
Descripción del Articulo
Project 334–2007-CONCYTEC-OAJ
| Autores: | , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2012 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/1239 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/1239 https://doi.org/10.1016/j.jep.2012.07.015 |
| Nivel de acceso: | acceso abierto |
| Materia: | Uncaria tomentosa Bacteria (microorganisms) Murinae Mus Rubiaceae https://purl.org/pe-repo/ocde/ford#3.01.05 |
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CONC_78fa38f089b91cbfed60d932719680f0 |
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oai:repositorio.concytec.gob.pe:20.500.12390/1239 |
| network_acronym_str |
CONC |
| network_name_str |
CONCYTEC-Institucional |
| repository_id_str |
4689 |
| dc.title.none.fl_str_mv |
Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark |
| title |
Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark |
| spellingShingle |
Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark Rojas-Duran, R Uncaria tomentosa Bacteria (microorganisms) Bacteria (microorganisms) Murinae Mus Rubiaceae Rubiaceae https://purl.org/pe-repo/ocde/ford#3.01.05 |
| title_short |
Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark |
| title_full |
Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark |
| title_fullStr |
Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark |
| title_full_unstemmed |
Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark |
| title_sort |
Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark |
| author |
Rojas-Duran, R |
| author_facet |
Rojas-Duran, R Gonzalez-Aspajo, G Ruiz-Martel, C Bourdy, G Doroteo-Ortega, VH Alban-Castillo, J Robert, G Auberger, P Deharo, E |
| author_role |
author |
| author2 |
Gonzalez-Aspajo, G Ruiz-Martel, C Bourdy, G Doroteo-Ortega, VH Alban-Castillo, J Robert, G Auberger, P Deharo, E |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rojas-Duran, R Gonzalez-Aspajo, G Ruiz-Martel, C Bourdy, G Doroteo-Ortega, VH Alban-Castillo, J Robert, G Auberger, P Deharo, E |
| dc.subject.none.fl_str_mv |
Uncaria tomentosa |
| topic |
Uncaria tomentosa Bacteria (microorganisms) Bacteria (microorganisms) Murinae Mus Rubiaceae Rubiaceae https://purl.org/pe-repo/ocde/ford#3.01.05 |
| dc.subject.es_PE.fl_str_mv |
Bacteria (microorganisms) Bacteria (microorganisms) Murinae Mus Rubiaceae Rubiaceae |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.01.05 |
| description |
Project 334–2007-CONCYTEC-OAJ |
| publishDate |
2012 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2012 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/1239 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.jep.2012.07.015 |
| dc.identifier.isi.none.fl_str_mv |
309990000005 |
| url |
https://hdl.handle.net/20.500.12390/1239 https://doi.org/10.1016/j.jep.2012.07.015 |
| identifier_str_mv |
309990000005 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Journal of Ethnopharmacology |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier B.V. |
| publisher.none.fl_str_mv |
Elsevier B.V. |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1844883109452972032 |
| spelling |
Publicationrp03569600rp03564600rp03566600rp01881500rp03565600rp03567600rp03568600rp03570600rp01885500Rojas-Duran, RGonzalez-Aspajo, GRuiz-Martel, CBourdy, GDoroteo-Ortega, VHAlban-Castillo, JRobert, GAuberger, PDeharo, E2024-05-30T23:13:38Z2024-05-30T23:13:38Z2012https://hdl.handle.net/20.500.12390/1239https://doi.org/10.1016/j.jep.2012.07.015309990000005Project 334–2007-CONCYTEC-OAJEthnopharmacological relevance: Uncaria tomentosa (Willd. ex Roem. & Schult.) DC. (Rubiaceae) is widely used by populations living in South America to treat many ailments associated with inflammatory disorders. Mitraphylline was shown to be the major pentacyclic oxindolic alkaloid present in the bark chloroformic extract of this plant. Its activity against cytokines involved in inflammation process was tested in a murine model in vivo. Materials and methodsMice received mitraphylline once a day for 3 days at 30 mg/kg/day by oral route. Then, they were subjected to bacterial lipopolysaccharide (LPS) endotoxin (15 mg/kg) and the LPS-induced production of 16 different cytokines was determined by Elisa multiplex. Control group received dexamethasone orally at 2 mg/kg/day. Toxicity on K565 cells and murine peritoneal macrophages, in vitro, at doses up to 100 μM was monitored by XTT-colorimetric assay. Results and conclusions: For the first time mitraphylline was tested in vivo against a large range of cytokines that play a crucial role in inflammation. Mitraphylline inhibited around 50% of the release of interleukins 1α, 1β, 17, and TNF-α. This activity was similar to dexamethasone. It also reduced almost 40% of the production of interleukin 4 (IL-4) while the corticoid did not. Lastly it did not show any toxicity on K565 cells nor murine macrophages at doses up to 100 μM.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengElsevier B.V.Journal of Ethnopharmacologyinfo:eu-repo/semantics/openAccessUncaria tomentosaBacteria (microorganisms)-1Bacteria (microorganisms)-1Murinae-1Mus-1Rubiaceae-1Rubiaceae-1https://purl.org/pe-repo/ocde/ford#3.01.05-1Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa barkinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/1239oai:repositorio.concytec.gob.pe:20.500.12390/12392024-05-30 16:02:00.372http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="5d9c5292-1067-4ecf-a873-0915eb773d14"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark</Title> <PublishedIn> <Publication> <Title>Journal of Ethnopharmacology</Title> </Publication> </PublishedIn> <PublicationDate>2012</PublicationDate> <DOI>https://doi.org/10.1016/j.jep.2012.07.015</DOI> <ISI-Number>309990000005</ISI-Number> <Authors> <Author> <DisplayName>Rojas-Duran, R</DisplayName> <Person id="rp03569" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gonzalez-Aspajo, G</DisplayName> <Person id="rp03564" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Ruiz-Martel, C</DisplayName> <Person id="rp03566" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Bourdy, G</DisplayName> <Person id="rp01881" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Doroteo-Ortega, VH</DisplayName> <Person id="rp03565" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Alban-Castillo, J</DisplayName> <Person id="rp03567" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Robert, G</DisplayName> <Person id="rp03568" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Auberger, P</DisplayName> <Person id="rp03570" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Deharo, E</DisplayName> <Person id="rp01885" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Elsevier B.V.</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>Uncaria tomentosa</Keyword> <Keyword>Bacteria (microorganisms)</Keyword> <Keyword>Bacteria (microorganisms)</Keyword> <Keyword>Murinae</Keyword> <Keyword>Mus</Keyword> <Keyword>Rubiaceae</Keyword> <Keyword>Rubiaceae</Keyword> <Abstract>Ethnopharmacological relevance: Uncaria tomentosa (Willd. ex Roem. & Schult.) DC. (Rubiaceae) is widely used by populations living in South America to treat many ailments associated with inflammatory disorders. Mitraphylline was shown to be the major pentacyclic oxindolic alkaloid present in the bark chloroformic extract of this plant. Its activity against cytokines involved in inflammation process was tested in a murine model in vivo. Materials and methodsMice received mitraphylline once a day for 3 days at 30 mg/kg/day by oral route. Then, they were subjected to bacterial lipopolysaccharide (LPS) endotoxin (15 mg/kg) and the LPS-induced production of 16 different cytokines was determined by Elisa multiplex. Control group received dexamethasone orally at 2 mg/kg/day. Toxicity on K565 cells and murine peritoneal macrophages, in vitro, at doses up to 100 μM was monitored by XTT-colorimetric assay. Results and conclusions: For the first time mitraphylline was tested in vivo against a large range of cytokines that play a crucial role in inflammation. Mitraphylline inhibited around 50% of the release of interleukins 1α, 1β, 17, and TNF-α. This activity was similar to dexamethasone. It also reduced almost 40% of the production of interleukin 4 (IL-4) while the corticoid did not. Lastly it did not show any toxicity on K565 cells nor murine macrophages at doses up to 100 μM.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.882791 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
