A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis

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Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication. Pyrazinamide (PZA) shortens these regimens from 9 to 6 months, and therefore, improves treatment completion rates. Although...

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Detalles Bibliográficos
Autores: Rueda D., Furukawa R., Fuentes P., Comina G., Rey De Castro N.G., Requena D., Gilman R.H., Sheen P., Zimic M.
Formato: artículo
Fecha de Publicación:2018
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/495
Enlace del recurso:https://hdl.handle.net/20.500.12390/495
https://doi.org/10.4103/ijmy.ijmy_63_18
Nivel de acceso:acceso abierto
Materia:water
gold
platinum
pyrazinamide
pyrazinoic acid
tuberculostatic agent
antibiotic resistance
Article
bacterium identification
concentration (parameters)
controlled study
cyclic potentiometry
electric current
Mycobacterium tuberculosis
nonhuman
priority journal
supernatant
analogs and derivatives
culture medium
drug effect
electrochemical analysis
https://purl.org/pe-repo/ocde/ford#3.03.00
id CONC_54a416044dd12a326fdabe284b48319c
oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/495
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis
title A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis
spellingShingle A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis
Rueda D.
water
gold
platinum
pyrazinamide
pyrazinoic acid
pyrazinamide
pyrazinoic acid
tuberculostatic agent
antibiotic resistance
Article
bacterium identification
concentration (parameters)
controlled study
cyclic potentiometry
electric current
Mycobacterium tuberculosis
nonhuman
priority journal
supernatant
analogs and derivatives
culture medium
drug effect
electrochemical analysis
https://purl.org/pe-repo/ocde/ford#3.03.00
title_short A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis
title_full A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis
title_fullStr A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis
title_full_unstemmed A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis
title_sort A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis
author Rueda D.
author_facet Rueda D.
Furukawa R.
Fuentes P.
Comina G.
Rey De Castro N.G.
Requena D.
Gilman R.H.
Sheen P.
Zimic M.
author_role author
author2 Furukawa R.
Fuentes P.
Comina G.
Rey De Castro N.G.
Requena D.
Gilman R.H.
Sheen P.
Zimic M.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rueda D.
Furukawa R.
Fuentes P.
Comina G.
Rey De Castro N.G.
Requena D.
Gilman R.H.
Sheen P.
Zimic M.
dc.subject.none.fl_str_mv water
topic water
gold
platinum
pyrazinamide
pyrazinoic acid
pyrazinamide
pyrazinoic acid
tuberculostatic agent
antibiotic resistance
Article
bacterium identification
concentration (parameters)
controlled study
cyclic potentiometry
electric current
Mycobacterium tuberculosis
nonhuman
priority journal
supernatant
analogs and derivatives
culture medium
drug effect
electrochemical analysis
https://purl.org/pe-repo/ocde/ford#3.03.00
dc.subject.es_PE.fl_str_mv gold
platinum
pyrazinamide
pyrazinoic acid
pyrazinamide
pyrazinoic acid
tuberculostatic agent
antibiotic resistance
Article
bacterium identification
concentration (parameters)
controlled study
cyclic potentiometry
electric current
Mycobacterium tuberculosis
nonhuman
priority journal
supernatant
analogs and derivatives
culture medium
drug effect
electrochemical analysis
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.03.00
description Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication. Pyrazinamide (PZA) shortens these regimens from 9 to 6 months, and therefore, improves treatment completion rates. Although PZA is a first-line medication for the treatment of TB, no simple or reliable assay to determine PZA resistance is yet available. In the presence of PZA, only susceptible Mycobacterium tuberculosis strains release pyrazinoic acid (POA). Therefore, the measurement and quantification of released POA is an indicator of PZA resistance.
publishDate 2018
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/495
dc.identifier.doi.none.fl_str_mv https://doi.org/10.4103/ijmy.ijmy_63_18
dc.identifier.scopus.none.fl_str_mv 2-s2.0-85053128180
url https://hdl.handle.net/20.500.12390/495
https://doi.org/10.4103/ijmy.ijmy_63_18
identifier_str_mv 2-s2.0-85053128180
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv International Journal of Mycobacteriology
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.publisher.none.fl_str_mv Wolters Kluwer Medknow Publications
publisher.none.fl_str_mv Wolters Kluwer Medknow Publications
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
_version_ 1844883055676751872
spelling Publicationrp00603600rp00602600rp00525500rp00605600rp00600600rp00601600rp00604600rp00526500rp00606600Rueda D.Furukawa R.Fuentes P.Comina G.Rey De Castro N.G.Requena D.Gilman R.H.Sheen P.Zimic M.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2018https://hdl.handle.net/20.500.12390/495https://doi.org/10.4103/ijmy.ijmy_63_182-s2.0-85053128180Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication. Pyrazinamide (PZA) shortens these regimens from 9 to 6 months, and therefore, improves treatment completion rates. Although PZA is a first-line medication for the treatment of TB, no simple or reliable assay to determine PZA resistance is yet available. In the presence of PZA, only susceptible Mycobacterium tuberculosis strains release pyrazinoic acid (POA). Therefore, the measurement and quantification of released POA is an indicator of PZA resistance.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengWolters Kluwer Medknow PublicationsInternational Journal of Mycobacteriologyinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/watergold-1platinum-1pyrazinamide-1pyrazinoic acid-1pyrazinamide-1pyrazinoic acid-1tuberculostatic agent-1antibiotic resistance-1Article-1bacterium identification-1concentration (parameters)-1controlled study-1cyclic potentiometry-1electric current-1Mycobacterium tuberculosis-1nonhuman-1priority journal-1supernatant-1analogs and derivatives-1culture medium-1drug effect-1electrochemical analysis-1https://purl.org/pe-repo/ocde/ford#3.03.00-1A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosisinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/495oai:repositorio.concytec.gob.pe:20.500.12390/4952024-05-30 15:57:38.202https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="114f50ca-282b-411f-b0c6-125bc54a2992"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis</Title> <PublishedIn> <Publication> <Title>International Journal of Mycobacteriology</Title> </Publication> </PublishedIn> <PublicationDate>2018</PublicationDate> <DOI>https://doi.org/10.4103/ijmy.ijmy_63_18</DOI> <SCP-Number>2-s2.0-85053128180</SCP-Number> <Authors> <Author> <DisplayName>Rueda D.</DisplayName> <Person id="rp00603" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Furukawa R.</DisplayName> <Person id="rp00602" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Fuentes P.</DisplayName> <Person id="rp00525" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Comina G.</DisplayName> <Person id="rp00605" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Rey De Castro N.G.</DisplayName> <Person id="rp00600" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Requena D.</DisplayName> <Person id="rp00601" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gilman R.H.</DisplayName> <Person id="rp00604" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Sheen P.</DisplayName> <Person id="rp00526" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Zimic M.</DisplayName> <Person id="rp00606" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Wolters Kluwer Medknow Publications</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by-nc-nd/4.0/</License> <Keyword>water</Keyword> <Keyword>gold</Keyword> <Keyword>platinum</Keyword> <Keyword>pyrazinamide</Keyword> <Keyword>pyrazinoic acid</Keyword> <Keyword>pyrazinamide</Keyword> <Keyword>pyrazinoic acid</Keyword> <Keyword>tuberculostatic agent</Keyword> <Keyword>antibiotic resistance</Keyword> <Keyword>Article</Keyword> <Keyword>bacterium identification</Keyword> <Keyword>concentration (parameters)</Keyword> <Keyword>controlled study</Keyword> <Keyword>cyclic potentiometry</Keyword> <Keyword>electric current</Keyword> <Keyword>Mycobacterium tuberculosis</Keyword> <Keyword>nonhuman</Keyword> <Keyword>priority journal</Keyword> <Keyword>supernatant</Keyword> <Keyword>analogs and derivatives</Keyword> <Keyword>culture medium</Keyword> <Keyword>drug effect</Keyword> <Keyword>electrochemical analysis</Keyword> <Abstract>Tuberculosis (TB) is a significant cause of morbidity and mortality worldwide. The patient compliance with the long treatment regimens is essential for successful eradication. Pyrazinamide (PZA) shortens these regimens from 9 to 6 months, and therefore, improves treatment completion rates. Although PZA is a first-line medication for the treatment of TB, no simple or reliable assay to determine PZA resistance is yet available. In the presence of PZA, only susceptible Mycobacterium tuberculosis strains release pyrazinoic acid (POA). Therefore, the measurement and quantification of released POA is an indicator of PZA resistance.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.991016
A novel inexpensive electrochemical sensor for pyrazinoic acid as a potential tool for the identification of pyrazinamide-resistant Mycobacterium tuberculosis
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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

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