Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers

Descripción del Articulo

CONCYTEC is acknowledged for financing Alexander Fox's grant.
Detalles Bibliográficos
Autores: Ramos, AEF, Alcover, C, Maciuk, A, Duplais, C, Bernadat, G, Dejean, C, Jullian, JC, Grellier, P, Poupon, E, Evanno, L, Champy, P, Beniddir, MA
Formato: objeto de conferencia
Fecha de Publicación:2016
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/1161
Enlace del recurso:https://hdl.handle.net/20.500.12390/1161
https://doi.org/10.1055/s-0036-1596203
Nivel de acceso:acceso abierto
Materia:monoterpenoid indole alkaloid
HPLC-ESI-Q/TOF
molecular networking
Geissospermum laeve
https://purl.org/pe-repo/ocde/ford#1.06.10
id CONC_4964b880b64f67226ab1d3ce812506e6
oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/1161
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers
title Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers
spellingShingle Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers
Ramos, AEF
monoterpenoid indole alkaloid
HPLC-ESI-Q/TOF
HPLC-ESI-Q/TOF
molecular networking
molecular networking
Geissospermum laeve
Geissospermum laeve
https://purl.org/pe-repo/ocde/ford#1.06.10
title_short Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers
title_full Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers
title_fullStr Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers
title_full_unstemmed Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers
title_sort Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers
author Ramos, AEF
author_facet Ramos, AEF
Alcover, C
Maciuk, A
Duplais, C
Bernadat, G
Dejean, C
Jullian, JC
Grellier, P
Poupon, E
Evanno, L
Champy, P
Beniddir, MA
author_role author
author2 Alcover, C
Maciuk, A
Duplais, C
Bernadat, G
Dejean, C
Jullian, JC
Grellier, P
Poupon, E
Evanno, L
Champy, P
Beniddir, MA
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ramos, AEF
Alcover, C
Maciuk, A
Duplais, C
Bernadat, G
Dejean, C
Jullian, JC
Grellier, P
Poupon, E
Evanno, L
Champy, P
Beniddir, MA
dc.subject.none.fl_str_mv monoterpenoid indole alkaloid
topic monoterpenoid indole alkaloid
HPLC-ESI-Q/TOF
HPLC-ESI-Q/TOF
molecular networking
molecular networking
Geissospermum laeve
Geissospermum laeve
https://purl.org/pe-repo/ocde/ford#1.06.10
dc.subject.es_PE.fl_str_mv HPLC-ESI-Q/TOF
HPLC-ESI-Q/TOF
molecular networking
molecular networking
Geissospermum laeve
Geissospermum laeve
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#1.06.10
description CONCYTEC is acknowledged for financing Alexander Fox's grant.
publishDate 2016
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/1161
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1055/s-0036-1596203
dc.identifier.isi.none.fl_str_mv 411789300027
url https://hdl.handle.net/20.500.12390/1161
https://doi.org/10.1055/s-0036-1596203
identifier_str_mv 411789300027
dc.language.iso.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Thieme
publisher.none.fl_str_mv Thieme
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
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spelling Publicationrp02718500rp01951500rp00829500rp01956500rp01960500rp03290600rp01957500rp01961500rp01955500rp01959500rp01950500rp01954500Ramos, AEFAlcover, CMaciuk, ADuplais, CBernadat, GDejean, CJullian, JCGrellier, PPoupon, EEvanno, LChampy, PBeniddir, MA2024-05-30T23:13:38Z2024-05-30T23:13:38Z2016https://hdl.handle.net/20.500.12390/1161https://doi.org/10.1055/s-0036-1596203411789300027CONCYTEC is acknowledged for financing Alexander Fox's grant.The approaches for the detection of natural products have evolved into more sophisticated ones thanks to the benefits of the big data era. In that context, a dereplication technique, called molecular networking, has been exploited by our team to undertake the phytochemical study of Geissospermum laeve (Vell.) Miers, a South American plant belonging to the Apocynceae family [1]. Applying this approach we sought the identification and isolation of minor compounds presenting original chemical structures. The molecular networking is based on the acquisition of chromatographic and spectral data by HPLC-ESI-Q/TOF, which then is displayed in the form of molecular networks of MS/MS fragmentation [2]. The application to the ethanolic extract from the stems of the plant allowed the identification and subsequent isolation of three new molecules, with a particularly original novel skeleton within the broad class of monoterpenoid indole alkaloids. Their isolation, structural elucidation, cytotoxicity and antiplasmodial activities are presented in this communication.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengThiemeinfo:eu-repo/semantics/openAccessmonoterpenoid indole alkaloidHPLC-ESI-Q/TOF-1HPLC-ESI-Q/TOF-1molecular networking-1molecular networking-1Geissospermum laeve-1Geissospermum laeve-1https://purl.org/pe-repo/ocde/ford#1.06.10-1Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miersinfo:eu-repo/semantics/conferenceObjectreponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#20.500.12390/1161oai:repositorio.concytec.gob.pe:20.500.12390/11612024-05-30 15:23:49.513http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="d088f357-33e8-4701-91fd-0d7389c7107f"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers</Title> <PublishedIn> <Publication> </Publication> </PublishedIn> <PublicationDate>2016</PublicationDate> <DOI>https://doi.org/10.1055/s-0036-1596203</DOI> <ISI-Number>411789300027</ISI-Number> <Authors> <Author> <DisplayName>Ramos, AEF</DisplayName> <Person id="rp02718" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Alcover, C</DisplayName> <Person id="rp01951" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Maciuk, A</DisplayName> <Person id="rp00829" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Duplais, C</DisplayName> <Person id="rp01956" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Bernadat, G</DisplayName> <Person id="rp01960" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Dejean, C</DisplayName> <Person id="rp03290" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Jullian, JC</DisplayName> <Person id="rp01957" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Grellier, P</DisplayName> <Person id="rp01961" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Poupon, E</DisplayName> <Person id="rp01955" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Evanno, L</DisplayName> <Person id="rp01959" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Champy, P</DisplayName> <Person id="rp01950" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Beniddir, MA</DisplayName> <Person id="rp01954" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Thieme</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>monoterpenoid indole alkaloid</Keyword> <Keyword>HPLC-ESI-Q/TOF</Keyword> <Keyword>HPLC-ESI-Q/TOF</Keyword> <Keyword>molecular networking</Keyword> <Keyword>molecular networking</Keyword> <Keyword>Geissospermum laeve</Keyword> <Keyword>Geissospermum laeve</Keyword> <Abstract>The approaches for the detection of natural products have evolved into more sophisticated ones thanks to the benefits of the big data era. In that context, a dereplication technique, called molecular networking, has been exploited by our team to undertake the phytochemical study of Geissospermum laeve (Vell.) Miers, a South American plant belonging to the Apocynceae family [1]. Applying this approach we sought the identification and isolation of minor compounds presenting original chemical structures. The molecular networking is based on the acquisition of chromatographic and spectral data by HPLC-ESI-Q/TOF, which then is displayed in the form of molecular networks of MS/MS fragmentation [2]. The application to the ethanolic extract from the stems of the plant allowed the identification and subsequent isolation of three new molecules, with a particularly original novel skeleton within the broad class of monoterpenoid indole alkaloids. Their isolation, structural elucidation, cytotoxicity and antiplasmodial activities are presented in this communication.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.371579
Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers
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