Oxygen pressure and acid-base balance of mother and fetus during labor at high altitude

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The oxygen tensión and acid-bases status of mother and fetus have been studied at delivery in 12 subjects from Lima (150 m.] and Cerro de Pasco (4,200 ,m.), Perú. Despite the low pO2 (60.7 ± 2 mm.Hg., x ± SEM) of maternal arterial blood at altitude, the tension of oxygen measured in microsamples of...

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Autores: Sobrevilla, Luis, Cassinelli, María, Carcelen, A., Málaga, Juan
Formato: artículo
Fecha de Publicación:2015
Institución:Sociedad Peruana de Obstetricia y Ginecología
Repositorio:Revista SPOG - Revista Peruana de Ginecología y Obstetricia
Lenguaje:español
OAI Identifier:oai:ojs.spog:article/800
Enlace del recurso:http://www.spog.org.pe/web/revista/index.php/RPGO/article/view/800
Nivel de acceso:acceso abierto
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network_name_str Revista SPOG - Revista Peruana de Ginecología y Obstetricia
dc.title.none.fl_str_mv Oxygen pressure and acid-base balance of mother and fetus during labor at high altitude
Tensión de oxígeno y equilibrio ácido-base de madre y feto durante el parto en la altura
title Oxygen pressure and acid-base balance of mother and fetus during labor at high altitude
spellingShingle Oxygen pressure and acid-base balance of mother and fetus during labor at high altitude
Sobrevilla, Luis
title_short Oxygen pressure and acid-base balance of mother and fetus during labor at high altitude
title_full Oxygen pressure and acid-base balance of mother and fetus during labor at high altitude
title_fullStr Oxygen pressure and acid-base balance of mother and fetus during labor at high altitude
title_full_unstemmed Oxygen pressure and acid-base balance of mother and fetus during labor at high altitude
title_sort Oxygen pressure and acid-base balance of mother and fetus during labor at high altitude
dc.creator.none.fl_str_mv Sobrevilla, Luis
Cassinelli, María
Carcelen, A.
Málaga, Juan
author Sobrevilla, Luis
author_facet Sobrevilla, Luis
Cassinelli, María
Carcelen, A.
Málaga, Juan
author_role author
author2 Cassinelli, María
Carcelen, A.
Málaga, Juan
author2_role author
author
author
dc.contributor.none.fl_str_mv

dc.description.none.fl_txt_mv The oxygen tensión and acid-bases status of mother and fetus have been studied at delivery in 12 subjects from Lima (150 m.] and Cerro de Pasco (4,200 ,m.), Perú. Despite the low pO2 (60.7 ± 2 mm.Hg., x ± SEM) of maternal arterial blood at altitude, the tension of oxygen measured in microsamples of arterialized capillary blood from the fetal scalp was similar at altitude (19.0 ± 1.16 mm.Hg.) and sea level (21.5 ± 1.12 mm.Hg.). The fetus at altitude is born with a mixed acid-base disturbance that combines a respiratory alcalosis (pCO2 = 29.8 ± 3.4 mm.Hg.) with a metabolic acidosis (base-excess = -7.4 ± 1.6 m.Eq./L) and a pH similar to that found at sea level. The low fetal pCO2 correlotes welI with a decreased maternal pC02, at altitude, due to the additive effects of the hiperventilations of altitude and pregnancy (r = 0.77, p < 0 .001). There is a high degree of correlation between the maternal pCO2 and the fetal base-excess (r = 0.73, p < 0.001). Our findinqs indicate that the neonate at altitude is frecuently "small for dates", with the corresponding risks of congenital malformations, hipoglicemia and pulmonary pathology. They will thus have on important meaning on the observed increase in neonatal mortality at altitude.
Quizás quisiste decir: The oxygen tensión and acid-bases status of mother and fetus have been studied at delivery in 12 subjects from Lima (150 m.] and Cerro de Pasco (4,200 ,m.), Perú. Despite the low pO2 (60.7 ± 2 mm.Hg., x ± SEM) of maternal arterial blood at altitude, the tension of oxygen measured in microsamples of arterialized capillary blood from the fetal scalp was similar at altitude (19.0 ± 1.16 mm.Hg.) and sea level (21.5 ± 1.12 mm.Hg.). The fetus at altitude is born with a mixed acid-base disturbance that combines a respiratory alcalosis (pCO2 = 29.8 ± 3.4 mm.Hg.) with a metabolic acidosis (base-excess = -7.4 ± 1.6 m.Eq./L) and a pH similar to that found at sea level. The low fetal pCO2 correlotes welI with a decreased maternal pC02, at altitude, due to the additive effects of the hyperventilations of altitude and pregnancy (r = 0.77, p < 0 .001). There is a high degree of correlation between the maternal pCO2 and the fetal base-excess (r = 0.73, p < 0.001). Our findings indicate that the neonate at altitude is frecuently "small for dates", with the corresponding risks of congenital malformations, hipoglicemia and pulmonary pathology. They will thus have on important meaning on the observed increase in neonatal mortality at altitude.El estado de la tensión de oxígeno y ácido-base de la madre y el feto se han estudiado en el parto en 12 sujetos de Lima (150 m.] Y Cerro de Pasco (4200, m.), Perú. A pesar de la baja pO2 (60,7 ± 2 mm. Hg., x ± SEM) de la sangre arterial materna en la altura, la tensión de oxígeno medido en micromuestras de sangre capilar arterializada del cuero cabelludo fetal fue similar en la altura (19,0 ± 1,16 mm Hg) y el nivel del mar (21,5 ± 1,12 mm .hg.). El feto en la altitud nace con una alteración ácido-base mixta que combina una alcalosis respiratoria (pCO2 = 29,8 ± 3,4 mm Hg) con una acidosis metabólica (base-exceso = -7,4 ± 1,6 m.eq ./L) y un pH similar al que se encuentra a nivel del mar. Las bajas fetales correlotes pCO2 weli con pC02 materna disminuyó, en altitud, debido a los efectos aditivos de los hiperventilations de altitud y el embarazo (r = 0,77, p <00,001). Existe un alto grado de correlación entre la pCO2 materna y la fetal base exceso (r = 0,73, p <0,001). Nuestros findinqs indican que el recién nacido en la altura es Frecuentes "pequeño para las fechas", con el correspondiente riesgos de malformaciones congénitas, hipoglicemia y la patología pulmonar. Por lo que tendrán un significado importante en el aumento observado en la mortalidad neonatal en la altura.
description The oxygen tensión and acid-bases status of mother and fetus have been studied at delivery in 12 subjects from Lima (150 m.] and Cerro de Pasco (4,200 ,m.), Perú. Despite the low pO2 (60.7 ± 2 mm.Hg., x ± SEM) of maternal arterial blood at altitude, the tension of oxygen measured in microsamples of arterialized capillary blood from the fetal scalp was similar at altitude (19.0 ± 1.16 mm.Hg.) and sea level (21.5 ± 1.12 mm.Hg.). The fetus at altitude is born with a mixed acid-base disturbance that combines a respiratory alcalosis (pCO2 = 29.8 ± 3.4 mm.Hg.) with a metabolic acidosis (base-excess = -7.4 ± 1.6 m.Eq./L) and a pH similar to that found at sea level. The low fetal pCO2 correlotes welI with a decreased maternal pC02, at altitude, due to the additive effects of the hiperventilations of altitude and pregnancy (r = 0.77, p < 0 .001). There is a high degree of correlation between the maternal pCO2 and the fetal base-excess (r = 0.73, p < 0.001). Our findinqs indicate that the neonate at altitude is frecuently "small for dates", with the corresponding risks of congenital malformations, hipoglicemia and pulmonary pathology. They will thus have on important meaning on the observed increase in neonatal mortality at altitude.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://www.spog.org.pe/web/revista/index.php/RPGO/article/view/800
10.31403/rpgo.v17i800
url http://www.spog.org.pe/web/revista/index.php/RPGO/article/view/800
identifier_str_mv 10.31403/rpgo.v17i800
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv http://www.spog.org.pe/web/revista/index.php/RPGO/article/view/800/759
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedad Peruana de Obstetricia y Ginecología
publisher.none.fl_str_mv Sociedad Peruana de Obstetricia y Ginecología
dc.source.none.fl_str_mv Revista Peruana de Ginecología y Obstetricia; Vol. 17, Núm. 1 y 2 (1971); 45-66
2304-5132
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reponame:Revista SPOG - Revista Peruana de Ginecología y Obstetricia
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reponame_str Revista SPOG - Revista Peruana de Ginecología y Obstetricia
collection Revista SPOG - Revista Peruana de Ginecología y Obstetricia
instname_str Sociedad Peruana de Obstetricia y Ginecología
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spelling Oxygen pressure and acid-base balance of mother and fetus during labor at high altitudeTensión de oxígeno y equilibrio ácido-base de madre y feto durante el parto en la alturaSobrevilla, LuisCassinelli, MaríaCarcelen, A.Málaga, JuanThe oxygen tensión and acid-bases status of mother and fetus have been studied at delivery in 12 subjects from Lima (150 m.] and Cerro de Pasco (4,200 ,m.), Perú. Despite the low pO2 (60.7 ± 2 mm.Hg., x ± SEM) of maternal arterial blood at altitude, the tension of oxygen measured in microsamples of arterialized capillary blood from the fetal scalp was similar at altitude (19.0 ± 1.16 mm.Hg.) and sea level (21.5 ± 1.12 mm.Hg.). The fetus at altitude is born with a mixed acid-base disturbance that combines a respiratory alcalosis (pCO2 = 29.8 ± 3.4 mm.Hg.) with a metabolic acidosis (base-excess = -7.4 ± 1.6 m.Eq./L) and a pH similar to that found at sea level. The low fetal pCO2 correlotes welI with a decreased maternal pC02, at altitude, due to the additive effects of the hiperventilations of altitude and pregnancy (r = 0.77, p < 0 .001). There is a high degree of correlation between the maternal pCO2 and the fetal base-excess (r = 0.73, p < 0.001). Our findinqs indicate that the neonate at altitude is frecuently "small for dates", with the corresponding risks of congenital malformations, hipoglicemia and pulmonary pathology. They will thus have on important meaning on the observed increase in neonatal mortality at altitude.Quizás quisiste decir: The oxygen tensión and acid-bases status of mother and fetus have been studied at delivery in 12 subjects from Lima (150 m.] and Cerro de Pasco (4,200 ,m.), Perú. Despite the low pO2 (60.7 ± 2 mm.Hg., x ± SEM) of maternal arterial blood at altitude, the tension of oxygen measured in microsamples of arterialized capillary blood from the fetal scalp was similar at altitude (19.0 ± 1.16 mm.Hg.) and sea level (21.5 ± 1.12 mm.Hg.). The fetus at altitude is born with a mixed acid-base disturbance that combines a respiratory alcalosis (pCO2 = 29.8 ± 3.4 mm.Hg.) with a metabolic acidosis (base-excess = -7.4 ± 1.6 m.Eq./L) and a pH similar to that found at sea level. The low fetal pCO2 correlotes welI with a decreased maternal pC02, at altitude, due to the additive effects of the hyperventilations of altitude and pregnancy (r = 0.77, p < 0 .001). There is a high degree of correlation between the maternal pCO2 and the fetal base-excess (r = 0.73, p < 0.001). Our findings indicate that the neonate at altitude is frecuently "small for dates", with the corresponding risks of congenital malformations, hipoglicemia and pulmonary pathology. They will thus have on important meaning on the observed increase in neonatal mortality at altitude.El estado de la tensión de oxígeno y ácido-base de la madre y el feto se han estudiado en el parto en 12 sujetos de Lima (150 m.] Y Cerro de Pasco (4200, m.), Perú. A pesar de la baja pO2 (60,7 ± 2 mm. Hg., x ± SEM) de la sangre arterial materna en la altura, la tensión de oxígeno medido en micromuestras de sangre capilar arterializada del cuero cabelludo fetal fue similar en la altura (19,0 ± 1,16 mm Hg) y el nivel del mar (21,5 ± 1,12 mm .hg.). El feto en la altitud nace con una alteración ácido-base mixta que combina una alcalosis respiratoria (pCO2 = 29,8 ± 3,4 mm Hg) con una acidosis metabólica (base-exceso = -7,4 ± 1,6 m.eq ./L) y un pH similar al que se encuentra a nivel del mar. Las bajas fetales correlotes pCO2 weli con pC02 materna disminuyó, en altitud, debido a los efectos aditivos de los hiperventilations de altitud y el embarazo (r = 0,77, p <00,001). Existe un alto grado de correlación entre la pCO2 materna y la fetal base exceso (r = 0,73, p <0,001). Nuestros findinqs indican que el recién nacido en la altura es Frecuentes "pequeño para las fechas", con el correspondiente riesgos de malformaciones congénitas, hipoglicemia y la patología pulmonar. Por lo que tendrán un significado importante en el aumento observado en la mortalidad neonatal en la altura.Sociedad Peruana de Obstetricia y Ginecología2015-06-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://www.spog.org.pe/web/revista/index.php/RPGO/article/view/80010.31403/rpgo.v17i800Revista Peruana de Ginecología y Obstetricia; Vol. 17, Núm. 1 y 2 (1971); 45-662304-51322304-5124reponame:Revista SPOG - Revista Peruana de Ginecología y Obstetriciainstname:Sociedad Peruana de Obstetricia y Ginecologíainstacron:SPOGspahttp://www.spog.org.pe/web/revista/index.php/RPGO/article/view/800/759info:eu-repo/semantics/openAccess2021-05-31T15:51:07Zmail@mail.com -
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