Paroxysmal nocturnal hemoglobinuria in pregnancy: report of a case and literature review

• Autores: Sepúlveda-Rivera, Cintia María, Vargas-Trujillo, Samuel, Ruiz-Beltrán, Arturo Maximiliano, Mora-Galván, Jessica Aidée, León-Domínguez, Jefsi Argelia
• Formato: artículo
• Fecha de Publicación: 2019
• Institución: Sociedad Peruana de Obstetricia y Ginecología
• Repositorio: Revista SPOG - Revista Peruana de Ginecología y Obstetricia
• Lenguaje: español
• OAI Identifier: oai:ojs.spog:article/2192
• Enlace del recurso: http://www.spog.org.pe/web/revista/index.php/RPGO/article/view/2192
• Nivel de acceso: acceso abierto

Objectives: To describe the perinatal results in a patient with paroxysmal nocturnal hemoglobinuria. Methods: We present the case of a patient diagnosed with paroxysmal nocturnal hemoglobinuria at the Instituto Nacional de Perinatología, Mexico. Case report: The 19-year-old patient presented a 26-week pregnancy and pancytopenia. Infectious, pharmacological and autoimmune etiologies were discarded. Flow cytometry identified paroxysmal nocturnal hemoglobinuria clone type II/III in over 50% of granulocytes and monocytes. During pregnancy, the management consisted in transfusion support and anticoagulation with acenocoumarin. Delivery occurred at 38.5 weeks of gestation. The patient was then referred to a bone marrow transplant unit.