Helicobacter pylori and gastric premalignant lesions in patients with non-studied dyspepsia in a general hospital in Lima

• Autores: Manrique-Lemus, María Nelly, Rojas-Vilca, José Luis, Soriano-Álvarez, César, Palomino-Portilla, Eugenio
• Formato: artículo
• Fecha de Publicación: 2019
• Institución: Sociedad Peruana de Medicina Interna
• Repositorio: Revista SPMI - Revista de la Sociedad Peruana de Medicina Interna
• Lenguaje: español
• OAI Identifier: oai:ojs.medicinainterna.net.pe:article/3
• Enlace del recurso: http://revistamedicinainterna.net/index.php/spmi/article/view/3
• Nivel de acceso: acceso abierto
• Materia: Helicobacter pylori; gastritis; dysplasia; metaplasia; prermalignancy; dyspepsia; displasia; premalignidad; dispepsia

Objective. To determine the frequency of infection by Helicobacter pylori (HP) and premalignant gastric lesions (PGL) in patients with non-studied dyspepsia, in a general hospitalin Lima. Material and methods. It was carried out a descriptive, cross-sectional, retrospective study. The study population corresponded to outpatients referred to the Hospital EsSalud Uldarico Rocca Fernandez, Villa El Salvador, Lima, with a diagnosis of non-studied dyspepsia, who underwent upper gastrointestinal endoscopy between April 2012 and March 2014. Clinical and anatomopathological characteristics were evaluated. Results. 2 790 patients were studied, average age 48,6 (SD ± 15,3) year-old, range: 14-91 year-old. We found a global frequency of HP infection in 61,3 % (95%CI: 59,5-63,1) and premalignant gastric lesions in 23,6 % (95%CI: 22-25,1). A statistically significant association was found between patients with positive HP and PGL (chi square = 14,6, p < 0,01). The HP infection was 62,5% in those who had atrophic gastritis), 64,6 % in those with complete intestinal metaplasia, 56,8 % in those with incomplete intestinal metaplasia and 32,5 % in those with dysplasia. Conclusions. The frequency of Helicobacter pylori (HP) infection and premalignant gastric lesions was high in patients with non-studied dyspepsia undergoing endoscopy in the study population; and, only a significant association was found between HP with complete intestinal metaplasia and dysplasia.