Introduction: Autoimmune encephalitis comprises a wide spectrum of immunological disorders, among them anti-NMDAR is the most frequent. The management of this pathology is complex due to multiple circumstances. Case report: A 19-year-old woman who started a subacute clinical picture with associated behavioral and neurological disorder: hallucinations, heteroaggressiveness, akinetic mutism, epileptic seizures, orofacial dyskinesias, fever and reported transient cardiac arrhythmia. MRI was normal, EEG recorded delta brush waves, CSF and serum studies were negative for secondary causes. Treatment was started with Acyclovir, an anti-crisis drug, and psychotropic drugs, later methylprednisolone with immunoglobulin was started without a satisfactory response. She starts treatment with Rituximab presenting a favorable response. The CSF panel was positive for NMDA. Control with progressive de-es...

INTRODUCTION: Magnesium is the fourth most abundant cation in the body, that is involving in more than 300 enzymatic reactions in numerous physiological functions and in the pathophysiology of many diseases affecting the surgical patient, is related to the physiology of pain by the NMDA receptors which are physiologically blocked by this ion. A noxa or painful stimulus maintained, increased levels of glutamate and substance P being able to remove the magnesium ion and facilitate depolarization NMDA receptor triggered and an increase in intracellular Ca2 + and activation of a number of enzyme systems leading to a state neuronal hyperexcitability and facilitates maintaining nociceptive transmission. MATERIALS AND METHODS: One of a prospective observational cohort study, which included a case group and a control every 42 patients each group; both groups were measured in serum magnesium leve...