The Royal Swedish Academy of Sciences awarded the 2020 Nobel Prize in Chemistry to two scientists, Dr. Emmanuelle Charpentier of the Max Planck Unit for Pathogen Science (Berlin, Germany), and Dr. Jennifer A. Doudna of the University of California (Berkeley, USA), for the development of a method for genome editing, one of the most resonant tools of the last decade: CRISPR/Cas9 genetic scissors. Nowadays, scientists can change the DNA of animals, plants and microorganisms with extremely high precision. The new CRISPR/Cas9 technology also has a revolutionary impact on human medicine, helping to generate new cancer therapies and even curing inherited diseases. The objectives of the present work are to mention the background, the importance of the discovery of genomic editing with CRISPR/Cas9, the molecular mechanism and the current applications of this valuable biotechnological tool in huma...

The Royal Swedish Academy of Sciences awarded the 2020 Nobel Prize in Chemistry to two scientists, Dr. Emmanuelle Charpentier of the Max Planck Unit for Pathogen Science (Berlin, Germany), and Dr. Jennifer A. Doudna of the University of California (Berkeley, USA), for the development of a method for genome editing, one of the most resonant tools of the last decade: CRISPR/Cas9 genetic scissors. Nowadays, scientists can change the DNA of animals, plants and microorganisms with extremely high precision. The new CRISPR/Cas9 technology also has a revolutionary impact on human medicine, helping to generate new cancer therapies and even curing inherited diseases. The objectives of the present work are to mention the background, the importance of the discovery of genomic editing with CRISPR/Cas9, the molecular mechanism and the current applications of this valuable biotechnological tool in huma...

The Royal Swedish Academy of Sciences awarded the 2020 Nobel Prize in Chemistry to two scientists, Dr. Emmanuelle Charpentier of the Max Planck Unit for Pathogen Science (Berlin, Germany), and Dr. Jennifer A. Doudna of the University of California (Berkeley, USA), for the development of a method for genome editing, one of the most resonant tools of the last decade: CRISPR/Cas9 genetic scissors. Nowadays, scientists can change the DNA of animals, plants and microorganisms with extremely high precision. The new CRISPR/Cas9 technology also has a revolutionary impact on human medicine, helping to generate new cancer therapies and even curing inherited diseases. The objectives of the present work are to mention the background, the importance of the discovery of genomic editing with CRISPR/Cas9, the molecular mechanism and the current applications of this valuable biotechnological tool in huma...

En el presente año, el Instituto Karolinska de Suecia entrega el Premio Nobel en Fisiología - Medicina al Investigador Yoshinori Ohsumi por su trabajo “mecanismos en autofagia”. Sin embargo, previo a este acontecimiento, el descubrimiento del “bisturí del DNA o proteína CRISPR-Cas9”, realizado por Feng Zhang, Jennifer Doudna y Emmanuelle Charpentier ha tenido numerosos premios. En noviembre del 2015 se publicó “Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi”, donde muestran la eficacia de edición del DNA de esta proteína, en el que el DNA modificado del mosquito bloquea al Plasmodium, iniciándose así una era en la cual se puede agregar o quitar genes del DNA, es decir, editar el DNA, gracias a esta proteína. DOI:https://doi.org/10.25176/RFMH.v16.n2.675

En el presente año, el Instituto Karolinska de Suecia entrega el Premio Nobel en Fisiología - Medicina al Investigador Yoshinori Ohsumi por su trabajo “mecanismos en autofagia”. Sin embargo, previo a este acontecimiento, el descubrimiento del “bisturí del DNA o proteína CRISPR-Cas9”, realizado por Feng Zhang, Jennifer Doudna y Emmanuelle Charpentier ha tenido numerosos premios. En noviembre del 2015 se publicó “Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi”, donde muestran la eficacia de edición del DNA de esta proteína, en el que el DNA modificado del mosquito bloquea al Plasmodium, iniciándose así una era en la cual se puede agregar o quitar genes del DNA, es decir, editar el DNA, gracias a esta proteína. DOI:https://doi.org/10.25176/RFMH.v16.n2.675