Urinary Excretion of 17- ketosteroids and 17-21 Dihydroxy -20- ketosteroids in Native Sea Level and Height

• Autor: Pretell Zárate, Eduardo
• Formato: artículo
• Fecha de Publicación: 1961
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/6280
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/6280
• Nivel de acceso: acceso abierto

We did not find differences between high altitude natives and native sea level in the urinary excretion of 17- ketosteroids and 17,21 - dihydroxy -20- ketosteroids in baseline conditions . After intravenous administration of hydrocortisone , the amount of urinary steroids appearing in the urine within 24 hours , is equal to the high altitude native and native sea level. This result is interpreted to mean that the catabolism of hydrocortisone is also similar , and that the same urinary excretion at baseline reflects equal hydrocortisone production by the adrenal cortex . By inhibiting the endogenous corticotrophin, by dexamethasone , urinary excretion of steroids in equal magnitude decreases in the two groups studied . This result is interpreted in the sense that equality in the production of hydrocortisone is intrinsically dependent on the adrenal cortex.