Calidad fisicoquímica de tobramicina 0,3% solución oftálmica de un laboratorio farmacéutico nacional

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  • This report of pre-professional practices describes the tests carried out in order to determine the physicochemical quality of tobramycin 0.3% ophthalmic solution, according to the specifications established by the Pharmacopoeia of the United States of America (USP) 41, using a Study sample of 60 bo...

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Main Author: Lecca Olortegui, Darwin Samuel
Format: Tesis de grado
Language: spa
Published: 2019
Subjects:
Online Access: http://dspace.unitru.edu.pe/handle/UNITRU/14058
Summary:This report of pre-professional practices describes the tests carried out in order to determine the physicochemical quality of tobramycin 0.3% ophthalmic solution, according to the specifications established by the Pharmacopoeia of the United States of America (USP) 41, using a Study sample of 60 bottles of ophthalmic solutions from a national pharmaceutical laboratory. The results obtained were: colorless, transparent solution, free of visible particles; an average volume of 5.3 mL and pH 7.72. Performed the identification, content and particle tests, tobramycin meets the retention times according to the titration, the titration test is within the specified range with 3.32 mg / mL (110.7%) and the particle count test due to light obstruction, 0 particles of diameter ≥ 10 um were found; complying with all the results according to the values established in the official USP 41 standard. It is concluded that tobramycin 0.3% ophthalmic solution complies with the specifications of USP 41.

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