Exactitud global de las concentraciones plasmáticas de antígeno prostático específico en el diagnóstico de cáncer de próstata - hospital regional docente de Trujillo, octubre del 2009 - junio 2010

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  • Objective. To determine the diagnostic accuracy of plasma prostate-specific antigen for prostate cancer diagnosis Material and methods. This retrospective, analytical and transversal study evaluated a total of 98 male patients prostatectomized by cancer (n = 18) and without cancer (n = 80) treated a...

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Main Author: Loayza Palomino, Carlos Alberto
Format: Tesis de doctorado
Language: spa
Published: 2011
Subjects:
Online Access: http://dspace.unitru.edu.pe/handle/UNITRU/5419
Summary:Objective. To determine the diagnostic accuracy of plasma prostate-specific antigen for prostate cancer diagnosis Material and methods. This retrospective, analytical and transversal study evaluated a total of 98 male patients prostatectomized by cancer (n = 18) and without cancer (n = 80) treated at the Teaching Regional Hospital from Trujillo, in October 2009 - June 2010. Results. The average age for the global series of 78 ± 8.84 years. Each one of the patients was underwent analysis of prostate specific antigen (PSA) and then were they did realized prostatectomy and histological examination of the prostate. We also reviewed each of the medical records of patients in the study and the statistical analysis used the chi square test. It was found that plasma levels of PSA had a sensitivity of 100%, specificity of 53.75%, 32.73% of positive predictive value and negative predictive value of 100%. The accuracy of the test was 62.24%. Plasma concentrations of prostate-specific antigen in patients with prostate cancer had an average of 49.76 ± 38.48 ng/ml in those without cancer and 5.90 ± 4.64 ng/ml. The frequency of adenocarcinoma of the prostate in patients with PSA > 4 ng / ml was 32.7%. In any patient with prostate adenocarcinoma was observed PSA levels less than or equal to 4 ng / ml (P <0.001) Conclusions. Plasma concentrations of prostate-specific antigen to diagnose prostate cancer have an accuracy of over 60% with high sensitivity and negative predictive value.

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