Characterization of the V4 and T1 polymorphism of the ADAM33 gene and its association with the development of asthma: Caracterización del polimorfismo V4 y T1 del gen ADAM33 y su asociación con el desarrollo del asma

• Autores: Monsalve Mera, Alain Eduard, Vega, Clarisa Carolina Arrascue, Nuñez, Rossana Menendez, Celestino-Segura, Walter Gutierrez, López, Luis Miguel Serquén
• Formato: artículo
• Fecha de Publicación: 2021
• Institución: Universidad Ricardo Palma
• Repositorio: Revistas - Universidad Ricardo Palma
• Lenguaje: español; inglés
• OAI Identifier: oai:oai.revistas.urp.edu.pe:article/3450
• Enlace del recurso: http://revistas.urp.edu.pe/index.php/RFMH/article/view/3450
• Nivel de acceso: acceso abierto
• Materia: asma; polimorfismo genético; gen ADAM33; Asthma; SNPs; ADAM proteins

Objective: To determine the association between the presence of V4 polymorphisms of the ADAM33 gene and asthma disease and to describe the frequency of T1 polymorphism in patients from a hospital in the Lambayeque region. Materials and methods: Design of cases and controls. Location: Hospital Almanzor Aguinaga Asenjo - EsSalud, level of complexity III-1. Population: patients between 5-17 years old attended by an outpatient clinic. The cases were patients diagnosed according to the Global Initiative for Asthma (GINA) 2016 guidelines. Controls were patients without a diagnosis of any chronic lung disease or a family history of asthma. Results: In most cases, both cases and controls did not present the V4 polymorphism, I feel positive only in 46% of cases and 31% of controls. When the association between the V4 polymorphism and the presence of asthma was evaluated, the OR was 1.93 (95% CI: 0.62 - 6.00), with a non-significant value (p = 0.196) for the Xi test --Pearson square. However, the T1 polymorphism was present in 87% of cases; and the proportion of Tumbesinos with the mutation was much lower than that of other regions. Conclusions: No association was found between the V4 polymorphism and the presence of asthma in patients from a Lambayeque hospital. The T1 polymorphism occurs quite frequently in asthmatic patients at Hospital Almanzor Aguinaga Asenjo - ESSalud.